Engineered Strategies to Interfere with Macrophage Fate in Myocardial Infarction

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: 11(2), P. 784 - 805

Published: Jan. 30, 2025

Myocardial infarction (MI), a severe cardiovascular condition, is typically triggered by coronary artery disease, resulting in ischemic damage and the subsequent necrosis of myocardium. Macrophages, known for their remarkable plasticity, are capable exhibiting range phenotypes functions as they react to diverse stimuli within local microenvironment. In recent years, there has been an increasing number studies on regulation macrophage behavior based tissue engineering strategies, its regulatory mechanisms deserve further investigation. This review first summarizes effects key factors engineered biomaterials (including bioactive molecules, conductivity, some microenvironmental factors) behavior, then explores specific methods inducing through materials promote myocardial repair, role macrophage-host cell crosstalk regulating inflammation, vascularization, remodeling. Finally, we propose future challenges macrophage-material interactions tailoring personalized guide phenotypes.

Language: Английский

Lactobacillus plantarum-Derived Inorganic Polyphosphate Regulates Immune Function via Inhibiting M1 Polarization and Resisting Oxidative Stress in Macrophages

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 428 - 428

Published: April 1, 2025

Inorganic polyphosphate (PolyP) is a high-molecular-weight polymer that plays multiple roles in regulating immune responses. However, the specific anti-inflammatory mechanisms of bacteria-derived PolyP are unclear. In present study, was extracted from Lactobacillus plantarum (L. plantarum), and chain length estimated to be approximately 250 Pi residues. The regulatory functions were investigated using lipopolysaccharide (LPS)-induced RAW264.7 cell oxidative stress model, dexamethasone used as positive control. result revealed both protective against by inhibiting macrophage M1 polarization production several markers, such nitric oxide (NO), reactive oxygen species (ROS), inducible synthase (iNOS), cyclooxygenase (COX)-2. addition, suppressed inflammation progression cytokines, interleukin (IL)-1β, interferon (INF)-γ, tumor necrosis factor (TNF)-α, IL-6, inhibited expressions inhibitory κB kinase (IKK) α, IKKβ, extracellular regulated protein kinases 2 (ERK2). Conclusively, derived L. has ability protect cells damage macrophages. These findings provide insights into function offer support for potential application immune-related diseases.

Language: Английский

Unveiling research hotspots: a bibliometric study on macrophages in musculoskeletal diseases

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Research on the role of macrophages in musculoskeletal (MSK) diseases has significantly increased recent years. However, a thorough evaluation developmental trajectory this field, including contributions prominent authors and primary research themes, remains insufficient. Furthermore, identification emerging hotspots requires more detailed exploration. This study collated articles reviews addressing “macrophages MSK diseases” published between 2004 2023, with all data extracted from Web Science database. The collected were analyzed using variety bibliometric visualization tools, such as VOSviewer, CiteSpace, GraphPad Prism, R packages. Results indicate that China United States are leading contributors domain. Among many academic institutions involved, Shanghai Jiao Tong University California stand out most productive. journal “Frontiers Immunology” had highest publication output topic. five frequently explored domains include Immunology, Rheumatology, Pharmacology Pharmacy, Cell Biology, Biochemistry Molecular Biology. These results offer comprehensive overview current state field provide meaningful insights for guiding future studies.

Language: Английский