Cell Biology International, Journal Year: 2025, Volume and Issue: unknown
Published: May 14, 2025
ABSTRACT Regulatory T cells (Tregs), previously referred to as suppressor cells, represent a distinct subset of CD4+ that are uniquely specialized for immune suppression. They characterized by the constitutive expression transcription factor FoxP3 in their nuclei, along with CD25 (the IL‐2 receptor α‐chain) and CTLA‐4 on cell surface. Tregs not only restrict natural killer cell‐mediated cytotoxicity but also inhibit proliferation CD8+ T‐cells suppress interferon‐γ secretion ultimately impairing an effective antitumor response. Treg widely recognized significant barrier effectiveness tumor immunotherapy clinical settings. Extensive research has consistently shown play pivotal role facilitating initiation progression. Conversely, depletion been linked marked delay growth development.
Language: Английский