Frontiers in Behavioral Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 29, 2025

Introduction Food intake is regulated by two systems: homeostatic and hedonic. An imbalance between these systems can induce overconsumption, such as binge eating disorder (BED), associated with dysregulation of the dopamine reward system. The cannabinoid type 2 receptor (CB2R) has been identified in neurons may play an important role motivated behaviors, including food intake. Nevertheless, interaction D4 (DRD4) CB2R binge-like not yet identified. Therefore, present study aims to evaluate effects intraperitoneal administration DRD4 antagonist (L-745870), well coadministration either agonist (HU308) or (AM630), on palatable (PF) adult male mice. Methods We used 34 C57BL6/J All animals were housed individually had ad libitum access standard diet (SD) water. To intake, 1 h PF during 12 baseline test (BET) sessions. Mice then randomly assigned following treatment groups: 1) vehicle; 2) L-745870; 3) L-745870-HU308, 4) L-745870+AM630 be evaluated under effect treatments for three additionally BET Results Our results show that reduced PF, a induced even more pronounced reduction Conclusion These findings suggest dopaminergic endocannabinoid modulation mice, where activation participates modulating pathways reducing behavior.

Language: Английский