Shugan Jiangni Hewei Granule regulates synaptic plasticity in central sensitization via NGF/TrkA Signaling Pathways in psychological stress rats with nonerosive reflux disease DOI Creative Commons

Guang Bai,

Yuebo Jia, Tianzuo Wang

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: April 12, 2022

Abstract Objective. We sought to investigate the mechanism of visceral hypersensitivity improvement Shugan Jiangni Hewei Granules (SJHG) treatment non-erosive reflux disease (NERD) and provide an experimental basis for its clinical application. Methods. Fifty healthy male Sprague-Dawley (SD) rats were divided into 5 groups, with 10 in each group, including normal group (healthy rats), model (model without any treatment), SJHG Omeprazole k252a treated 100μmol/kg NGF/TrkA pathway inhibitor).The esophageal mucosa synaptic vesicles spinal cord observed by EMT, NGF, TrkA, PSD95, GAP43 proteins expression detected western blot, GluA1 protein was immunohistochemistry among PSD95 immunofluorescence. Results. In intercellular spaces epithelia widened, increased compared group. NGF amd TrkA significantly (P<0.01), After or k252a, decreased rats. (P<0.01). GAP43, proeins higher than that group.(P<0.01). Compared (P<0.05), but no significant difference CREB mRNA expression. The content low. According integrated optical density (IOD), both signifcantly Conclusions. can ameliorate decrease central mental stress disease, which is partially due regulation signaling pathways. Psychological factor also important cause hypersensitivity. These findings provided a new target Traditional Chinese medicine NERD improve viscera.

Language: Английский

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update DOI Creative Commons
Chen Shen,

Yueheng Tang,

Yang Gao

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: April 8, 2022

Depression is a global health problem with growing prevalence rates and serious impacts on the daily life of patients. However, side effects currently used antidepressants greatly reduce compliance Quercetin flavonol present in fruits, vegetables, Traditional Chinese medicine (TCM) that has been proved to have various pharmacological such as anti-depressant, anti-cancer, antibacterial, antioxidant, anti-inflammatory, neuroprotective. This review summarizes evidence for application quercetin treat depression. We clarified mechanisms regulating levels neurotransmitters, promoting regeneration hippocampal neurons, improving hypothalamic-pituitary-adrenal (HPA) axis dysfunction, reducing inflammatory states anti-oxidative stress. also summarized antidepressant some glycoside derivatives provide reference further research clinical application.

Language: Английский

Citations

53
The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical applications DOI Creative Commons
Chen Shen, Ke Wang,

Hongzhan Wang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 201, P. 107090 - 107090

Published: Feb. 2, 2024

Depression is a major global health issue that urgently requires innovative and precise treatment options. In this context, saikosaponin has emerged as promising candidate, offering variety of therapeutic benefits may be effective in combating depression. This review delves into the multifaceted potential saikosaponins alleviating depressive symptoms. We summarized effects on structural functional neuroplasticity, elaborated regulatory mechanism modulating key factors affect such inflammation, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, brain-gut axis. Moreover, paper highlights existing gaps current researches outlines directions for future studies. A detailed plan provided clinical application saikosaponins, advocating more targeted to speed up its transition from preclinical trials practice.

Language: Английский

Citations

12
The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors DOI Creative Commons

Huina Ma,

Hehua Huang,

Chenyu Li

et al.

npj Systems Biology and Applications, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 13, 2024

Abstract Traditional Chinese medicine is one of the most commonly used complementary and alternative therapies for depression. Integrated Chinese-western have been extensively applied in numerous diseases due to their superior efficiency individual treatment. We meta-analysis, network pharmacology, bioinformatics studies identify putative role Longya Lilium combined with Fluoxetine Depression-like behaviors were mimicked mice after exposure chronic unpredictable mild stress (CUMS). The underlying potential mechanism this combination therapy was further explored based on vitro vivo experiments analyze expression COX-2, PGE2, IL-22, activation microglial cells, neuron viability apoptosis hippocampus. antidepressant effect noted compared a single COX-2 mainly expressed hippocampal CA1 areas. reduced thus alleviated depression-like behavior neuroinflammation mice. A decrease curtailed BV-2 cell activation, inflammation, by blunting PGE2/IL-22 axis. Therefore, inactivates COX-2/PGE2/IL-22 axis, consequently relieving neuroinflammatory response resultant

Language: Английский

Citations

6
Du-moxibustion ameliorates depression-like behavior and neuroinflammation in chronic unpredictable mild stress-induced mice DOI Creative Commons

Zhixia Jia,

Wenyan Yu, Xuhao Li

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 358, P. 211 - 221

Published: May 3, 2024

Neuroinflammation is involved in the advancement of depression. Du-moxibustion can treat Here, we explored whether could alleviate neuroglia-associated neuro-inflammatory process chronic unpredictable mild stress (CUMS) mice.

Language: Английский

Citations

4
Anti-colorectal cancer actions of Glycyrrhiza uralensis Fisch. and its underlying mechanism via HPLC integration and network pharmacological approaches DOI
Hong Duan, Zhao‐Jun Wei, Ying Shi

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156370 - 156370

Published: Jan. 7, 2025

Language: Английский

Citations

0
Improving hemodialysis patient depression outcomes with acupuncture: A randomized controlled trial DOI

Xijing Yu,

Shuisheng Hua,

Eun Hyo Jin

et al.

Acta Psychologica, Journal Year: 2025, Volume and Issue: 253, P. 104728 - 104728

Published: Jan. 30, 2025

Language: Английский

Citations

0
Amomum tsao-ko crevost et lemaire ameliorates depression-like behaviors and hippocampal inflammation by inhibiting microglia activation and HMGB1/TLR4/NF-κB pathway in diabetic mice with depression DOI
Zhen Wang,

Huilin Ren,

Caixia Wang

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(4)

Published: March 28, 2025

Language: Английский

Citations

0
Arecoline Alleviates Depression via Gut–Brain Axis Modulation, Neurotransmitter Balance, Neuroplasticity Enhancement, and Inflammation Reduction in CUMS Mice DOI

Meng Xu,

Wanggao Li,

Xiaosong Hu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

This study evaluated the antidepressant effects of arecoline, a bioactive alkaloid derived from areca nuts, using mouse model depression induced by chronic unpredictable mild stress. Arecoline treatment significantly alleviated depression-like behaviors, including anxiety, anhedonia, and despair, as evidenced behavioral tests. Mechanistically, arecoline restored serotonin norepinephrine levels in brain serum, reduced pro-inflammatory markers such IL-1β LPS both serum colon, enhanced hippocampal neuroplasticity through increased BDNF PSD-95 expression. Moreover, modulated gut microbiota composition, particularly enriching beneficial species like Bifidobacterium pseudolongum Ligilactobacillus murinus, regulated metabolites associated with tryptophan metabolism, neurotransmitter synthesis, oxidative These findings demonstrate that exerts its via multitargeted approach involving gut-brain axis, modulation, enhancement. highlights promising therapeutic candidate for depression, emphasizing potential to address central peripheral mechanisms.

Language: Английский

Citations

0
Formononetin ameliorates depression-like behaviors through rebalancing microglia M1/M2 polarization and inhibiting NLRP3 inflammasome: involvement of activating PPARα-mediated autophagy DOI Creative Commons

Shuaijun Peng,

Su Pan, Liming Liu

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: April 24, 2025

Abstract Background The dysregulation of neuroinflammation triggered by imbalance microglia M1/M2 polarization is a key pathogenic factor and closely associated with occurrence depression. Formononetin (FMN), natural non-steroidal isoflavonoid, has been confirmed to exhibit remarkable anti-inflammatory efficacy, but the impact FMN on depression underlying antidepressant mechanisms are still not fully understood. This study aimed investigate whether effect involved in modulating polarization, if so, what mechanisms. Methods Lipopolysaccharide (LPS)-induced depressive mice were used FMN. Microglia cell line BV2 stimulated LPS was employed pharmacological Effects neuronal damage detected H&E, Nissl Golgi staining. efficacy evaluated immunostaining western blots vivo vitro . In addition, molecular docking, luciferase reporter assay, cellular thermal shift assay (CETSA) drug affinity responsive target stability (DARTS) confirm direct Results Our results showed that significantly reverses depression-like behaviors, alleviates damage, rebalances inhibits NLRP3 inflammasome enhances microglial autophagy level prefrontal cortex LPS-induced mice. assays, unraveled inhibitor chloroquine (CQ) blocks effects inhibiting rebalancing polarization. Moreover, PPARα identified as can activate PPARα-mediated autophagy. Furtherly, combination agonist (WY14643) had no significant additive whereas antagonist (GW6471) abrogated these pharmacologic BV2. Importantly, GW6471 exhibited similar abolish Conclusion firstly demonstrated rebalance inhibit inflammasome, involvement activating ameliorate which provides novel view elucidate also offers potential therapeutic for

Language: Английский

Citations

0
Network pharmacology and experimental evidence: ERK/CREB/BDNF signaling pathway is involved in the antidepressive roles of Kaiyu Zhishen decoction DOI
Ying Chen, Xiangxu Chen, Jialin Zhang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118098 - 118098

Published: April 4, 2024

Language: Английский

Citations

3