Fitoterapia, Journal Year: 2024, Volume and Issue: 177, P. 106100 - 106100
Published: July 6, 2024
Language: Английский
Nutrients, Journal Year: 2023, Volume and Issue: 15(13), P. 3059 - 3059
Published: July 7, 2023
Alzheimer’s disease (AD) is the most common neurodegenerative illustrated by neuronal dysfunctions, leading to memory weaknesses and personality changes mostly in aged population worldwide. The exact cause of AD unclear, but numerous studies have addressed involvement oxidative stress (OS), induced reactive oxygen species (ROS), be one causes developing AD. OS dysregulates cellular homeostasis, causing abnormal protein lipid metabolism. Nutrition plays a pivotal role modulating antioxidant system decreases ROS level, thus playing an important therapeutic diseases, especially Hence, medicinal herbs their extracts received global attention as commercial source antioxidants Lupeol. Lupeol pentacyclic triterpenoid has many biological functions. It available fruits, vegetables, plants. shown effective anti-inflammatory properties, higher blood–brain barrier permeability. Also, binding inhibitory potentials been investigated proved against certain receptor proteins enzymes computational molecular docking approaches. Therefore, AD-related research gained interest investigating effects However, despite its beneficial AD, there still lack we compiled this analysis all preclinical that looked at agent for
Language: Английский
Citations
32
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: May 1, 2023
Ulcerative colitis (UC), a type of inflammatory bowel disease characterized by recurring and incurable symptoms, causes immense suffering economic burden for patients due to the limited treatment options available. Therefore, it is imperative develop novel promising strategies, as well safe effective drugs, clinical management UC. Macrophages play critical role initial line defense in maintaining intestinal immune homeostasis, their phenotypic transformation significantly influences progression Scientific studies have demonstrated that directing macrophage polarization toward M2 phenotype an strategy prevention Phytochemicals derived from botanical sources garnered interest scientific community owing distinct bioactivity nutritional value, which been shown confer beneficial protective effects against colonic inflammation. In this review, we explicated influence on development UC collated data significant potential natural substances can target elucidate possible mechanism action its treatment. These findings may provide directions references
Language: Английский
Citations
27
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(21), P. 4584 - 4599
Published: Jan. 1, 2023
Drug delivery systems (DDSs) are a multidisciplinary approach toward the effective of drugs to their target sites. Natural small molecule (NSM) compounds with anticancer activity, self-assembly and co-assembly functions show great potential for application as novel DDSs in biomedical field. NSMs widely sourced, have many modification sites, readily form hydrogen bonds, π-π interactions, van der Waals other non-covalent bonds solvents, resulting ordered structures. Moreover, good biocompatibility bioactivity allow compositions based on these be used life science applications such tissue engineering, drug cell imaging, showing medical value DDSs. In this review, we summarise role, assembly principles natural products triterpenoids, diterpenoids, sterols, alkaloids polysaccharides construction systems, which expected provide an important reference development more active nanomaterials study single or multi-component interactions.
Language: Английский
Citations
24
Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2155 - 2155
Published: July 8, 2024
Since ancient times,
Language: Английский
Citations
10
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12923 - 12923
Published: Aug. 18, 2023
Pentacyclic triterpenoids (TTs) represent a unique family of phytochemicals with interesting properties and pharmacological effects, some representatives, such as betulinic acid (BA) betulin (B), being mainly investigated potential anticancer molecules. Considering the recent scientific preclinical investigations, review their mechanisms, structure-related activity, efficiency improved by insertion in nanolipid vehicles for targeted delivery is presented. A systematic literature study about effects on tumor cells vitro vivo, free molecules or encapsulated liposomes nanolipids, discussed. special approach given to liposome-TTs nanolipid-TTs complexes be linked microbubbles, known contrast agents ultrasonography. The production supramolecular conjugates deliver drugs target via sonoporation represents new applicative direction improve TT efficiency, considering that they have limited availability lipophilic Relevant examples vivo studies, well challenges next steps towards application these complex systems cells, are discussed, opening directions innovative nanotechnological solutions.
Language: Английский
Citations
19
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4140 - 4140
Published: Feb. 18, 2023
Acute myeloid leukemia (AML) remains an insidious neoplasm due to the percentage of patients who develop resistance both classic chemotherapy and emerging drugs. Multidrug (MDR) is a complex process determined by multiple mechanisms, it often caused overexpression efflux pumps, most important which P-glycoprotein (P-gp). This mini-review aims examine advantages using natural substances as P-gp inhibitors, focusing on four molecules: phytol, curcumin, lupeol, heptacosane, their mechanism action in AML.
Language: Английский
Citations
14
Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 38, P. 101477 - 101477
Published: Feb. 19, 2024
The global population has been witnessing a growing awareness of the critical importance conserving biodiversity and preserving finite resources. However, despite this heightened awareness, exploitation natural resources continued to escalate, resulting in an ecological deficit placing excessive burden on planet's delicate ecosystems. In wake COVID-19 pandemic, consumers have become increasingly conscious environmental repercussions tied their consumption patterns. This consciousness led surge demand for sustainable products. Within cosmetic industry, concerted efforts are underway secure supply ingredients craft value-added products from renewable lupin industry generates substantial volumes by-products endowed with bioactive properties, including antioxidants, antimicrobial, anti-inflammatory, anti-cancer, anti-aging compounds, all which capability improve skin health. review focuses innovative concept using or upcycling derived its be used as substances topical formulations cosmetics dermocosmetics, strategy that offers both tangible health benefits positive impacts. Given limited research pharmaceutical applications seeds comparison other plant species, paper aims provide valuable insights into utilization these specific fields.
Language: Английский
Citations
5
Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155858 - 155858
Published: July 4, 2024
Language: Английский
Citations
5
Phytomedicine, Journal Year: 2023, Volume and Issue: 123, P. 155193 - 155193
Published: Nov. 8, 2023
Autoimmune myocarditis, with increasing incidence and limited therapeutic strategies, is in urgent need to explore its underlying mechanisms effective drugs. Pyroptosis a programmed cell death that may contribute the pathogenesis of myocarditis. Nonetheless, no direct evidence validated role pyroptosis autoimmune Lupeol (Lup), pentacyclic triterpene, possesses various biological activities such as antidiabetic properties. However, effects Lup on myocarditis remain unelucidated.
Language: Английский
Citations
12
Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107577 - 107577
Published: Jan. 5, 2025
RAS proteins, as pivotal signal transduction molecules, are frequently mutated and hyperactivated in various human cancers, closely associated with tumor cell proliferation, survival, metastasis. Despite extensive research on targeted therapies, developing effective inhibitors remains a significant challenge. Natural products, endowed unique chemical structures diverse biological activities through long-term natural selection, have emerged vital resource for discovering novel RAS-targeted therapeutic drugs. This review focuses the latest advancements targeting products categorizes these based their mechanisms of action. Additionally, we discuss challenges faced by during clinical translation, including issues related to pharmacokinetics. Strategies such combination therapy, structural optimization, drug delivery systems anticipated enhance efficacy overcome challenges. multiple mechanisms.
Language: Английский
Citations
0