Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice DOI Creative Commons
Shuang Liu, Weiyong Wang, Huiyu Liu

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 20, 2024

Language: Английский

Aerobic exercise mitigates hippocampal neuronal apoptosis by regulating DAPK1/CDKN2A/REDD1/FoXO1/FasL signaling pathway in D‐galactose‐induced aging mice DOI Creative Commons
Yang Liu, Wen Guo, Si‐Lu Hong

et al.

The FASEB Journal, Journal Year: 2023, Volume and Issue: 37(10)

Published: Sept. 28, 2023

Brain aging is the most important risk factor for neurodegenerative disorders, and abnormal apoptosis linked to neuronal dysfunction. Specifically, studies have found that exercise effectively inhibits hippocampal apoptosis, while molecular mechanism remains unclear. In present study, we investigated impact of aerobic on in mice potential involvement DAPK1 its downstream pathways based recent data may be associated with death diseases. Senescent were subjected 8 weeks Aerobic training. Following behavioral testing, samples examined histologically biochemically detect pathological changes, mRNA protein levels. We intervention improved spatial memory alleviated brain. Notably, down-regulated expression inhibited Fas receptor transactivation mitochondrial apoptotic pathway hippocampus. These results shed new light protective effect regular against brain though modulating pathway.

Language: Английский

Citations

6
SEPHS1 attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through the Hippo-Yap/Taz pathway DOI
Tao Hu,

Zhongming Shi,

Yongjin Sun

et al.

AJP Cell Physiology, Journal Year: 2023, Volume and Issue: 326(2), P. C386 - C399

Published: Dec. 18, 2023

Nucleus pulposus cell (NPC) senescence is a major cause of intervertebral disc degeneration (IVDD). Oxidative stress and reactive oxygen species (ROS) play critical roles in regulating senescence. Selenophosphate synthetase 1 (SEPHS1) was reported to an important role mitigating oxidative osteoarthritis (OA) model by reducing the production ROS, thereby, delaying occurrence development osteoarthritis. In this study, we explored the, hitherto unknown, SEPHS1 IVDD vitro vivo using interleukin-1β (IL-1β)-induced NPC rat needle puncture model, respectively. delayed ROS production. Age-related dysfunction also ameliorated overexpression inhibition Hippo-Yap/Taz signaling pathway. experiments revealed that alleviated rats. Moreover, selenium (Se)-deficient diet lack synergistically aggravated progression. Taken together, our results demonstrate plays significant Overexpression can delay senescence, restore balance extracellular matrix metabolism, attenuate IVDD. could be promising therapeutic target for

Language: Английский

Citations

6
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress DOI
Qingqiu Chen, Rong Hu, Hongmei Qiu

et al.

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 221, P. 111962 - 111962

Published: July 14, 2024

Language: Английский

Citations

1
Molecular Network Mechanism Analysis of Urine Stem Cells Against Retinal Aging DOI
Ning Bi, Na Li,

Hua Liu

et al.

Biochemical Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 25, 2024

Language: Английский

Citations

0
Cellular Aging Inhibitory Effect of Perilla Leaf Extract on D-Galactose Induced C2C12 Myoblasts DOI Open Access

Song-Mi Park,

Sung‐Woo Cho, Yung Hyun Choi

et al.

Journal of Korean Medicine Rehabilitation, Journal Year: 2024, Volume and Issue: 34(2), P. 15 - 28

Published: April 30, 2024

Objectives We used the D-galactose (D-gal) induced C2C12 myoblast senescence model to investigate whether ethanol extract of Perilla.fructescens leaves (EEPF) could delay cellular and regulate related mechanisms.Methods myogenic cells were cultured in an incubator under 37 ℃ 5% CO 2 conditions.EEPF, dried perilla pulverized extracted at 1:10 (v/v) 50 for 4 hours.Cell counting kit-8 western blot analysis was performed.Annexin V-FITC apoptosis detection kit DAPI staining applied.Catalase (CAT), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC), superoxide dismutase (SOD), malondialdehyde kits used.To measure level reactive oxygen species generation, flow cytometry analyze mitochondrial activity, membrane potential changes measured using JC-1.β-gal activity analyzed SA-β-gal solution, DNA damage by γ-H2AX.Quantikine ELISA inflammatory cytokine production.Results According results this study, EEPF significantly alleviated decrease cell viability treated with D-gal suppressed expression proliferating nuclear antigen.EEPF also markedly blocked D-gal-induced restored reduced CAT, GSH-Px, T-AOC, SOD.In addition, β-galactosidase induction increase senescence-associated secretory phenotype proteins such as p16, p53 p21 D-gal-treated cells.Furthermore, attenuated production cytokines interleukin (IL)-6 IL-18.Conclusions The study indicate that can be a candidate prevention treatment muscle aging.(

Language: Английский

Citations

0
RPE Senescence and Its Implication in Age-Related Macular Degeneration DOI
Shusheng Wang, Qi Zhou, Yao Tong

et al.

Essentials in ophthalmology/Essentials ophthalmology, Journal Year: 2024, Volume and Issue: unknown, P. 85 - 108

Published: Jan. 1, 2024

Language: Английский

Citations

0
Mechanistic insights of the anti-ageing dietary plant secondary metabolites vis-à-vis the modern hallmarks of ageing: implications for developing novel anti-ageing foods DOI Creative Commons
Rohit Sharma, Anamika Sharma

Translational Medicine of Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

0
Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice DOI Creative Commons
Shuang Liu, Weiyong Wang, Huiyu Liu

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 20, 2024

Language: Английский

Citations

0