The role of cellular senescence in neurodegenerative diseases

Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(8), P. 2393 - 2408

Published: May 15, 2024

Increasing evidence has revealed that cellular senescence drives NDs, including Alzheimer's disease (AD) and Parkinson's disease. Different senescent cell populations secrete senescence-associated secretory phenotypes (SASP), matrix metalloproteinase-3, interleukin (IL)-1α, IL-6, IL-8, which can harm adjacent microglia. Moreover, these cells possess high expression levels of hallmarks (p16 p21) elevated β-galactosidase activity in vitro vivo ND models. These contribute to the deposition β-amyloid tau-protein tangles. Selective clearance SASP regulation by inhibiting p38/mitogen-activated protein kinase nuclear factor kappa B signaling attenuate load prevent tangle deposition, thereby improving cognitive performance AD mouse In addition, telomere shortening, a biomarker, is associated with increased risks. Telomere dysfunction causes senescence, stimulating tumor necrosis factor-α, IL-1β secretions. The forced telomerase activators prevents yielding considerable neuroprotective effects. This review elucidates mechanism pathogenesis, suggesting strategies eliminate or restore normal phenotype for treating such diseases.

Language: Английский

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The anti-aging mechanism of ginsenosides with medicine and food homology

Food & Function, Journal Year: 2023, Volume and Issue: 14(20), P. 9123 - 9136

Published: Jan. 1, 2023

Ginsenosides resist the aging by regulating multiple signaling pathways.

Language: Английский

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Recent trends in ginseng research

Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 78(3), P. 455 - 466

Published: March 21, 2024

Language: Английский

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Vitamin D Improves Cognitive Impairment and Alleviates Ferroptosis via the Nrf2 Signaling Pathway in Aging Mice

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15315 - 15315

Published: Oct. 18, 2023

Ferroptosis is an iron-dependent mode of cell death associated with the occurrence and development age-related neurodegenerative diseases. Currently, there are no effective drugs available to prevent or treat these aging-related Vitamin D (VD) antioxidant immunomodulator, but its relationship ferroptosis in diseases has not been extensively studied. In this study, we aimed investigate role VD learning memory aging mice. To examine whether protects hippocampal neurons, used physiologically active 1,25(OH)2D3. We established models vivo (C57BL/6 mice) vitro (HT22 cells) using D-galactose (D-gal). The results demonstrated that could improve mice aged via use D-gal, it reduced damage neurons. regulate ferroptosis-related proteins (increasing GPX4 expression decreasing ACSL4 ALOX15 protein levels), increasing GSH levels, reducing MDA intracellular mitochondrial ROS as well total iron Fe2+ improving morphology, thereby alleviating Additionally, activated VDR/Nrf2/HO-1 signaling pathway, inhibiting ferroptosis. Notably, when VDR was knocked down, lost ability activate Nrf2. Consequently, Nrf2 decreased protective effect against summary, activates Nrf2/HO-1 pathway through VDR, effectively preventing induced by

Language: Английский

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Research Progress on the Anti-Aging Potential of the Active Components of Ginseng

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3286 - 3286

Published: July 25, 2023

Aging is a cellular state characterized by permanent cessation of cell division and evasion apoptosis. DNA damage, metabolic dysfunction, telomere mitochondrial dysfunction are the main factors associated with senescence. increases β-galactosidase activity, enhances spreading, induces Lamin B1 loss, which further accelerate aging process. It variety diseases, such as Alzheimer’s disease, Parkinson’s, type 2 diabetes, chronic inflammation. Ginseng traditional Chinese medicine anti-aging effects. The active components ginseng, including saponins, polysaccharides, peptides, have antioxidant, anti-apoptotic, neuroprotective, age-delaying damage factor aging, mechanism through ingredients ginseng reduce delay has not been comprehensively described. This review focuses on mechanisms ginseng. Furthermore, it broadens scope ideas for research natural products aging.

Language: Английский

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Harnessing Natural Saponins: Advancements in Mitochondrial Dysfunction and Therapeutic Applications

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156383 - 156383

Published: Jan. 10, 2025

Language: Английский

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An Update on Neuroaging on Earth and in Spaceflight

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1738 - 1738

Published: Feb. 18, 2025

Over 400 articles on the pathophysiology of brain aging, neuroaging, and neurodegeneration were reviewed, with a focus epigenetic mechanisms numerous non-coding RNAs. In particular, this review accent is microRNAs, discovery whose pivotal role in gene regulation was recognized by 2024 Nobel Prize Physiology or Medicine. Aging not gradual process that can be easily modeled described. Instead, multiple temporal processes occur during they lead to mosaic changes are uniform pace. The rate change depends combination external internal factors boosted accelerated aging. decrease decelerated aging due individual structural functional reserves created cognitive, physical training, pharmacological interventions. Neuroaging caused genetic changes, modifications, oxidative stress, inflammation, lifestyle, environmental factors, which especially noticeable space environments where adaptive trigger aging-like processes. Numerous candidate molecular biomarkers specific neuroaging need validated develop diagnostics countermeasures.

Language: Английский

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Comparative Study of Ginsenoside Rg2, 20(S)-Protopanaxatriol, and Afg from Ginseng on Aging-Related Kidney Injury in Samp8 Mice

Published: Jan. 1, 2025

Language: Английский

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Ginseng in Delaying Brain Aging: Progress and perspectives

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156587 - 156587

Published: March 1, 2025

Language: Английский

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Allium Macrostemon Bge. Attenuates the Cognitive Decline of Aging Mice by Enhancing BDNF/TrkB Pathway

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)

Published: Feb. 28, 2025

ABSTRACT Allium macrostemon Bge. (AM) is a widely utilized culinary spice recognized for its numerous health‐promoting properties. Aging‐related cognitive impairment (ARCI) represents significant global health concern during the aging process. However, potential of AM to attenuate ARCI has not been investigated. This work aims reveal effects and mechanisms water extraction (WEAM) in alleviating ARCI, with particular emphasis on BDNF/TrkB signaling pathway. The findings showed enhancement memory function reduction hippocampal neuronal damage mice following treatment WEAM, manifested by an increased spontaneous alternation rate Y‐maze, prolonged step‐through latency, decreased number errors PAT test, shortened escape latency platform swimming time crossing times MWM test. Additionally, WEAM reduced oxidative stress, elevated expression proteins related synaptic plasticity (SYN PSD95), activated pathway D‐galactose‐induced mice. To elucidate mechanism which alleviates both TrkB activator (7,8‐DHF) inhibitor (ANA‐12) were employed. results demonstrated that potentiated 7,8‐DHF diminished ANA‐12. Finally, 11 chemical compositions analyzed quantified using HPLC‐MS/MS, including macrostemonoside, sarsasapogenin, diosgenin, timosaponin AIII, N‐p‐trans‐coumaroyltyramine, guanosine, adenosine, phenylalanine, adenine, arginine, valine. These suggest may serve as promising mitigating promoting pathway, thereby enhancing plasticity.

Language: Английский

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