Bridging the Gap: Harnessing Plant Bioactive Molecules to Target Gut Microbiome Dysfunctions in Amyotrophic Lateral Sclerosis DOI Creative Commons

Mirela Pribac,

Anca Moțățăianu, Sebastian Andone

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 4471 - 4488

Published: May 8, 2024

The correlation between neurodegenerative diseases and the gut microbiome is increasingly evident, with amyotrophic lateral sclerosis (ALS) being particularly notable for its severity lack of therapeutic options. microbiota, implicated in pathogenesis development ALS, plays a crucial role disease. Bioactive plant molecules, specifically volatile compounds essential oils, offer promising avenue due to their anti-inflammatory properties gut-modulating effects. Our narrative review aimed identify microbiota-associated bacteria ALS analyze benefits administering bioactive molecules as much-needed options management this A comprehensive search PubMed database articles published before December 2023, encompassing research on cell, human, animal models, was conducted. After selecting, analyzing, discussing key articles, linked physiopathology were identified. Notably, positively highlighted included Akkermansia muciniphila (Verrucomicrobia phylum), Faecalibacterium prausnitzii, Butyrivibrio spp. (Firmicutes phylum). Conversely, members Escherichia coli (Proteobacteria phylum) Ruminococcus stood out negatively respect development. These associated molecular changes evolution. can be directly improvements microbiome, reducing inflammation oxidative stress, emerging one most natural agents enriching present-day treatments.

Language: Английский

An integrative study on the effects of Lingguizhugan decoction in treating Alzheimer's disease rats through modulation of multiple pathways involving various components DOI
Zhe Wang, Haotian Zhang, Siyue Li

et al.

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 191, P. 110149 - 110149

Published: April 13, 2025

Language: Английский

Citations

0
Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia DOI Creative Commons
Yifan Bu, Songzhe Li, Ting Ye

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

This study aims to elucidate the mitigating effects of volatile oil Acori tatarinowii rhizoma (ATR) on dementia, in order provide a reference for future research and applications ATR field dementia. A search strategy was developed using terms such as "Acori rhizoma," "Acorus Schott," "Asarone," "Dementia." The literature conducted PubMed, Web Science, Google Scholar, studies not meeting inclusion criteria were excluded. summarizes main metabolites, active ingredients, toxicological properties, pharmacokinetic characteristics from with particular focus its potential mechanisms action. Furthermore, highlights limitations existing offers insights into directions. mitigates dementia through multiple pathways, including reducing abnormal protein aggregation, promoting neurogenesis, inhibiting neuronal apoptosis, regulating neurotransmitters, improving synaptic function, modulating autophagy, countering cellular stress, neuroinflammation, alleviating vascular risk factors. multi-pathway pharmacological are well-aligned complex progression, highlighting significant therapeutic anti-dementia applications. provides new perspectives development more effective drugs. Nonetheless, further rigorous high-quality preclinical clinical investigations required address key issues, chemical characterization ATR, synergistic among toxicity profiles, definitive efficacy.

Language: Английский

Citations

0
KaiXinSan-JiaWei ameliorates cognitive dysfunction in APP/PS1 mice by intervening in gut microbiota and its metabolites DOI Creative Commons
Ludovica Mana, Fang Chen, Xiaoxia Yuan

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Alzheimer's disease (AD) is a degenerative of the central nervous system characterized by progressive cognitive impairment and memory loss. Chinese medicine's therapeutic effect on AD has become promising treatment option in recent years, herbal compound Kai Xin San-Jia Wei (KXSJW) one its representatives. This study employed comprehensive approach, including 16S rRNA Gaschromatography-mass spectrometry (GC-MS) analysis, to investigate efficacy intrinsic mechanism KXSJW AD. 50 3-month-old APPswe/PS1dE9 transgenic mice were randomly divided into 5 groups (n = 10): model group (M), donepezil (Don), KXSJW-low dose (KJW-L), KXSJW- medium (KJW-M), KXSJW-high (KJW-H), Ten C57BL/6 J wild-type selected as control (C). The administered saline gavage, was (0.92 mg/kg/d), KXSJW-low/medium/high extract (0.9/1.8/3.6 mL/kg/d); each treated once daily for 2 months. Morris Water Maze (MWM) evaluate learning abilities. Pathological changes colon tissue assessed through hematoxylin eosin (HE) staining. Analysis gut microbiota conducted using sequencing, microbial metabolite (short chain fatty acids, SCFAs) content detected GC-MS. Colonic barrier integrity examined immunohistochemistry western blot, while β-amyloid deposition brain assessed. ELISA used measure serum intestinal peptide hormones (Glucagon, GHRP-Ghrelin). enhanced ability memory, reduced amyloid mice. able restore balance flora regulate concentration metabolites, especially represented Firmicutes major butyric acid. Meanwhile, restored function improved release level GHRP-Ghrelin) indicates that can improve internal environment may homeostasis AD, with focus regulation microorganisms their subsequently Traditional Medicine (TCM) potential intervene multilevel interaction brain-gut-axis.

Language: Английский

Citations

0
Antiepileptic Effects of Acorus tatarinowii Schott in a Rat Model of Epilepsy: Regulation of Metabolic Axes and Gut Microbiota DOI Creative Commons
Liang Chen, Jiayan Li, Wenhui Zhang

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 488 - 488

Published: April 29, 2025

As a phytotherapeutic agent with historical applications in epilepsy management, Acorus tatarinowii Schott (ATS) remains pharmacologically enigmatic, particularly regarding its pathophysiological mechanisms. This knowledge gap significantly hinders the clinical application of ATS-based treatments. To explore potential ATS combating epileptogenesis, we utilized pentylenetetrazole (PTZ)-induced chronic rat model. Brain metabolomic analysis was performed by ultra-performance liquid chromatography coupled mass spectrometry (UPLC/MS). Principal component (PCA) and orthogonal projections to latent structures-discriminant (OPLS-DA) were for screening differential metabolites. Gut microbiota composition analyzed through 16S rRNA gene sequencing examined using Spearman correlation analysis. The results show that oral (50 mg/kg) improved seizure latency pathology rats epilepsy. Ascorbate aldarate metabolism, glycerophospholipid arachidonic acid intestinal flora crucial ATS’s ability counteract therapeutic effects against investigated brain metabolomics gut analysis, providing basis further comprehensive research.

Language: Английский

Citations

0
A Network Analysis Framework for Traditional Chinese Medicine in Treating Alzheimer’s Disease: From Core Herbal Pairs to Key Component Networks DOI Creative Commons
Fanjing Kong, Wei‐Ming Zhang, Tianyu Wu

et al.

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION), Journal Year: 2025, Volume and Issue: unknown, P. 100560 - 100560

Published: May 1, 2025

Language: Английский

Citations

0
The volatile oil of Acorus tatarinowii Schott ameliorates Alzheimer's disease through improving insulin resistance via activating the PI3K/AKT pathway DOI
Junhao Huang,

Zhiwei Xu,

C. C. Yu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156168 - 156168

Published: Oct. 20, 2024

Language: Английский

Citations

3
Pathogenesis of Alzheimer's Disease and Therapeutic Strategies Involving Traditional Chinese Medicine DOI

Shutang Li,

Jinfei Yang

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Alzheimer's disease (AD) is a prevalent degenerative disorder affecting the central nervous system of elderly. Patients primarily manifest cognitive decline and non-cognitive neuro-psychiatric symptoms. Currently, western medications for AD include cholinesterase inhibitors glutamate receptor inhibitors, which have limited efficacy accompanied by significant toxic side effects. Given intricate pathogenesis AD, use single-target limited. In recent years, as research on has progressed, traditional Chinese medicine (TCM) its active ingredients increasingly played crucial role in clinical treatment. Numerous studies demonstrate that TCM can exert anti-Alzheimer's effects modulating pathological protein production deposition, inhibiting tau hyperphosphorylation, apoptosis, inflammation, oxidative stress, while enhancing cholinergic system, protecting neurons synapses, optimizing energy metabolism. This article summarizes extracts from briefly elucidates their pharmacological mechanisms against aiming to provide foundation further into specific prevention treatment disease, well identification efficacious ingredients.

Language: Английский

Citations

2
Neuroprotective effects of traditional Chinese medicine Naofucong on diabetic cognitive impairment: Mechanisms involving insulin-degrading enzyme-mediated degradation of Amyloid-β and inhibition of ERK/JNK/p38 MAPK signaling pathway DOI Creative Commons

Yue Tian,

Guangchan Jing,

Ruiying Yin

et al.

Brain Research, Journal Year: 2024, Volume and Issue: unknown, P. 149365 - 149365

Published: Nov. 1, 2024

Language: Английский

Citations

2
Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition DOI Creative Commons
Jie Cao,

Lanqin Li,

Runge Zhang

et al.

Natural Products and Bioprospecting, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 26, 2024

Neurodegenerative diseases (NDs) are common chronic arising from progressive damage to the nervous system. Here, in-house natural product database screening revealed that libertellenone C (LC) obtained fermentation products of Arthrinium arundinis separated gut a centipede collected in our Tongji campus, showed remarkable neuroprotective effect. Further investigation was conducted clarify specific mechanism. LC dose-dependently reversed glutamate-induced decreased viability, accumulated reactive oxygen species, mitochondrial membrane potential loss, and apoptosis SH-SY5Y cells. Network pharmacology analysis predicted targets were most likely directly related oxidative stress regulation inflammatory factor-associated signaling pathways. study demonstrated attenuated nitrite, TNF-α, IL-1β production inducible nitric oxide synthase cyclooxygenase expression lipopolysaccharide-induced BV-2 could inhibit NLRP3 inflammasome activation by decreasing levels NLRP3, ASC, cleaved Caspase-1, NF-κB p65. Our results provide new understanding how inhibits microglia, providing neuroprotection. These findings might guide development effective LC-based therapeutic strategies for NDs.

Language: Английский

Citations

1
Huanshaodan regulates microglial glucose metabolism reprogramming to alleviate neuroinflammation in AD mice through mTOR/HIF-1α signaling pathway DOI Creative Commons

Congcong Shang,

Yunfang Su,

Jinlian Ma

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Abnormal glucose metabolism in microglial is closely associated with Alzheimer's disease (AD). Reprogramming of centered on regulating the way which metabolize to alter function. Therefore, reprogramming considered as a therapeutic strategy for AD. Huanshaodan (HSD) Chinese herbal compound shows significant efficacy treating AD, however, precise mechanism by HSD treats AD remains unclear. This study aim investigate whether exerts anti-AD effects metabolic through mTOR/HIF-1α signaling pathway. SAMP8 mice and BV2 cells were used explore alleviative effect molecular

Language: Английский

Citations

1