Essential oil from Inula japonica Thunb. And its phenolic constituents ameliorate pulmonary injury and fibrosis in bleomycin-treated mice

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117169 - 117169

Published: Sept. 11, 2023

Language: Английский

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Exploring the Molecular Mechanisms of Acorus tatarinowii and Ginseng in the Treatment of Autism Spectrum Disorder Based on Network Pharmacology and Molecular Docking

Current Chinese Science, Journal Year: 2024, Volume and Issue: 4(2), P. 145 - 157

Published: Feb. 4, 2024

Background: Acorus tatarinowii and Ginseng (AT-G) are traditional Chinese herbal medicines extensively utilized in neurological disorders treatment. However, due to the complex components of AT-G pathological mechanism ASD, mechanisms involved treatment ASD with remain elusive. Objective: We explored potential Methods: used network pharmacology approach evaluate beneficial effects for including obtaining active by Traditional Medicine Systems Pharmacology (TCMSP) platform, detecting targets genes associated Genecards DisGenet databases, analysis, virtual docking. Results: A total 26 components, 130 targets, 806 ASD-related were identified using bioinformatics analysis tool, TCMSP, Genecards, DisGenet. In intersection pharmacodynamic we 41 common targets. Then, GO enrichment revealed that mainly biological processes (i.e., positive regulation nitric oxide biosynthetic process, response xenobiotic stimulus), cellular presynaptic membrane postsynaptic membrane), molecular functions RNA polymerase II transcription factor activity, identical protein binding). KEGG pathway found enriched chemical carcinogenesis - receptor activation, fluid shear stress atherosclerosis, lipid IL-17 signaling pathways. addition, 10 core screened from PPI (e.g., TNF, AKT1, PTGS2, MMP, PPARG, IFNG, NOS2, TGFB1, CASP1). Molecular docking component kaempferol has a high affinity four primary disease Conclusion: Our results facilitated in-depth development their individual provided reference clinical practice

Language: Английский

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Exploring Acori Tatarinowii Rhizoma and Polygalae Radix in Alzheimer’s: Network pharmacology and molecular docking analysis

Medicine, Journal Year: 2024, Volume and Issue: 103(15), P. e37740 - e37740

Published: April 12, 2024

Explore Acori Tatarinowii Rhizoma (ATR) and Polygalae Radix (PR) mechanisms in Alzheimer’s disease (AD) treatment through network pharmacology. ATR-PR was investigated the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, Batman, Medicines Integrated Database (TCMID) to gather information on its chemical components target proteins. Target genes associated with AD were retrieved from GeneCards National Center for Biotechnology Information (NCBI) databases. The integration of these datasets potential targets facilitated construction an protein-protein interaction (PPI) using STRING database. resulting identified core active ingredients main treatment. Cluster analysis PPI performed Cytoscape 3.7.1. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses conducted Metascape Molecular docking simulations revealed interactions between targets. Our 8 putative 455 ATR-PR. We systematically searched 1306 AD, Venn diagram 156 common targets, constructed a 57 key GO functional highlighted primary biological processes oxidative stress. KEGG pathway involvement 64 signaling pathways, PI3K/Akt playing role. indicated high affinity compounds AD. This study sheds light complex involving context provide foundation understanding therapeutic mechanisms. stress-related crucial role suggest avenues targeted interventions proposition combined use has emerged as strategy supported by pharmacology approach. framework provides robust future clinical applications experimental research pursuit effective treatments.

Language: Английский

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Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits

Current Medical Science, Journal Year: 2024, Volume and Issue: 44(2), P. 450 - 461

Published: April 1, 2024

Language: Английский

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Bridging the Gap: Harnessing Plant Bioactive Molecules to Target Gut Microbiome Dysfunctions in Amyotrophic Lateral Sclerosis

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 4471 - 4488

Published: May 8, 2024

The correlation between neurodegenerative diseases and the gut microbiome is increasingly evident, with amyotrophic lateral sclerosis (ALS) being particularly notable for its severity lack of therapeutic options. microbiota, implicated in pathogenesis development ALS, plays a crucial role disease. Bioactive plant molecules, specifically volatile compounds essential oils, offer promising avenue due to their anti-inflammatory properties gut-modulating effects. Our narrative review aimed identify microbiota-associated bacteria ALS analyze benefits administering bioactive molecules as much-needed options management this A comprehensive search PubMed database articles published before December 2023, encompassing research on cell, human, animal models, was conducted. After selecting, analyzing, discussing key articles, linked physiopathology were identified. Notably, positively highlighted included Akkermansia muciniphila (Verrucomicrobia phylum), Faecalibacterium prausnitzii, Butyrivibrio spp. (Firmicutes phylum). Conversely, members Escherichia coli (Proteobacteria phylum) Ruminococcus stood out negatively respect development. These associated molecular changes evolution. can be directly improvements microbiome, reducing inflammation oxidative stress, emerging one most natural agents enriching present-day treatments.

Language: Английский

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