Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We? DOI Creative Commons

Lylian Ellen Militão dos Santos Xavier,

T. Reis,

Amylly Sanuelly da Paz Martins

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1369 - 1369

Published: Nov. 8, 2024

Inflammatory bowel diseases (IBD) pose a growing public health challenge with unclear etiology and limited efficacy of traditional pharmacological treatments. Alternative therapies, particularly antioxidants, have gained scientific interest. This systematic review analyzed studies from MEDLINE, Cochrane, Web Science, EMBASE, Scopus using keywords like “Inflammatory Bowel Diseases” “Antioxidants.” Initially, 925 publications were identified, after applying inclusion/exclusion criteria—covering July 2015 to June 2024 murine models or clinical trials in humans evaluating natural synthetic substances affecting oxidative stress markers—368 articles included. comprised 344 animal 24 human studies. The most investigated antioxidants polyphenols active compounds medicinal plants (n = 242; 70.3%). found strong link between inflammation IBD, especially on nuclear factor kappa B erythroid 2-related 2 pathways. However, it remains whether occurs first IBD. Lipid peroxidation was the studied damage, followed by DNA damage. Protein damage rarely investigated. relationship gut microbiota examined 103 Human markers scarce, reflecting major research gap IBD treatment. PROSPERO registration: CDR42022335357 CRD42022304540.

Language: Английский

Oxyberberine alleviates lipopolysaccharide-induced intestinal barrier disruption and inflammation in human colonic Caco-2 cells in vitro DOI Creative Commons
Cailan Li, Jiahao Wang, Hongmei Yang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Oxyberberine (OBB) is a naturally occurring isoquinoline alkaloid that believed to possess various health-promoting properties, including anti-fungus, hepatoprotection, anti-inflammation, and anti-intestinal mucositis effects. Despite several studies reporting the health benefits of OBB in treating ulcerative colitis (UC), its specific mechanism action has yet be fully elucidated. This investigation designed explore potential protective efficacy latent using an vitro model UC-like inflammatory intestinal cells. Caco-2 cells were pretreated with subsequently exposed lipopolysaccharide (LPS). The transepithelial electrical resistance (TEER), paracellular permeability, distribution expression tight- adherent junction proteins determined assess barrier integrity. levels proinflammatory cytokines, reactive oxygen species (ROS), Nrf2, NF-κB signaling cascade analyzed via ELISA, qRT-PCR, immunofluorescence, or Western blotting. was found mitigate effects LPS on cell monolayers, as evidenced by improvement TEER decrease FITC-dextran flux. Moreover, ameliorated LPS-induced tight markers, ZO-1, occludin, E-cadherin. In addition, treatment effectively inhibited increases ROS, apoptosis, Keap1 decreases Nrf2 HO-1. elevations nuclear p65 p-IκBα suppressed OBB. ML385, antagonist abolished role pronounced beneficial effect damage enteral function, regulation Nrf2/NF-κB pathway important responsible for protection afforded

Language: Английский

Citations

0
Study on the Optimization of an Extraction Process of Two Triterpenoid Saponins in the Root of Rosa laevigata Michx. and Their Protective Effect on Acute Lung Injury DOI Creative Commons

Jing-Ya Mo,

Qiaoyu Deng, Yuanyuan Huang

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 253 - 253

Published: Feb. 13, 2025

Objectives: Kajiichigoside F1 and rosamultin are natural triterpenoid saponins found in the root of Rosa laevigata Michx. These compounds isomers, making their separation challenging. Nonetheless, they have been reported to exhibit significant anti-inflammatory activity, although mechanism action remains unclear. This study aimed optimize extraction process echinacoside from R. elucidate mechanisms these an LPS-induced acute lung injury (ALI) model. Methods: The was optimized using a single-factor experiment Box-Behnken response surface methodology, with content kajiichigoside F1, rosamultin, total serving as evaluation indices. model induced by LPS, tissue damage assessed through hematoxylin eosin (HE) staining. secretion relevant inflammatory factors quantified enzyme-linked immunosorbent assay (ELISA), expression levels associated proteins were analyzed via Western blotting. Results: optimal conditions determined be ethanol volume fraction 80.0%, solid-liquid ratio 1:25, duration 80 min, three cycles. mitigate alveolar inflammation mice effectively reducing pro-inflammatory cytokines TNF-α IL-6. Additionally, down-regulated phosphorylated NF-κB p65 IκBα proteins, thereby alleviating symptoms. Conclusions: attenuate lipopolysaccharide (LPS) stimulation modulation signaling pathway. preliminarily elucidates mechanism, suggesting that both possess therapeutic potential for ALI. findings provide guidance future development active components derived establish foundation enhancing quality standards its medicinal materials.

Language: Английский

Citations

0
Berberine: an isoquinoline alkaloid targeting the oxidative stress and gut-brain axis in the models of depression DOI

Cong-Ya Chen,

Yi Zhang

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117475 - 117475

Published: March 1, 2025

Language: Английский

Citations

0
Biochanin A Mitigates Colitis by Inhibiting Ferroptosis-Mediated Intestinal Barrier Dysfunction, Oxidative Stress, and Inflammation via the JAK2/STAT3 Signaling Pathway DOI

Beiying Deng,

Kunpeng Wang, Haodong He

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156699 - 156699

Published: March 1, 2025

Language: Английский

Citations

0
Taurine alleviates colitis by regulating oxidative stress, inflammatory responses, ER stress, and apoptotic pathways DOI

Ankita Mandal,

Sharmistha Banerjee, Sumit Ghosh

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

Citations

0
Crataegus pinnatifida polysaccharide alleviates DSS-induced colitis in mice by regulating the intestinal microbiota and enhancing arginine biosynthesis DOI

Fan-Hao Wei,

Wen‐Yin Xie,

Pei‐Sen Zhao

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156794 - 156794

Published: April 1, 2025

Language: Английский

Citations

0
18β-Glycyrrhetinic Acid from Glycyrrhiza Uralensis Protects Colonic Epithelium in Ulcerative Colitis by activating Wnt/β-catenin pathway to restore Tight Junction DOI
Xi Peng,

Rao Zhong,

Shi Dong

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156830 - 156830

Published: May 1, 2025

Language: Английский

Citations

0
Absolute Quantitative Metagenomic Analysis Provides More Accurate Insights for the Anti-Colitis Effect of Berberine via Modulation of Gut Microbiota DOI Creative Commons
Jiaguo Zhan,

Jiale Cheng,

W. K. Chang

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 400 - 400

Published: March 11, 2025

Current gut microbiota studies often rely on relative quantitative sequencing. However, under certain circumstances, while the abundance of these bacteria may remain stable, absolute quantities specific can vary considerably. Since function is directly linked to their total numbers, quantification crucial. This study aims identify optimal method for microbiome analysis by comparing and Using ulcerative colitis, which closely associated with microbiota, as a disease model berberine (which affects microbiota) versus sodium butyrate does not) drugs, methods were used evaluate varying effects different drugs regulation in UC-affected animals. The regulatory BBR further synthesized identified earlier using an individual-based meta-analysis, we compared findings our sequencing results. results from more consistent actual microbial community, suggesting that measurements might not accurately reflect true species. Moreover, meta-analysis only partially sometimes opposed, analyses are prone misinterpretation incorrect correlation underscores importance representing counts sample evaluating modulatory microbiome, plays vital role microbiome.

Language: Английский

Citations

0
Effect of Dietary Patterns on Inflammatory Bowel Disease: A Machine Learning Bibliometric and Visualization Analysis DOI Open Access
Haodong He, Chuan Liu, Meilin Chen

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3442 - 3442

Published: Aug. 3, 2023

This study aimed to analyze the related research on influence of dietary patterns IBD carried out over past 30 years obtain context field and provide a scientific basis guidance for prevention treatment IBD.The literature effects inflammatory bowel disease published three decades was retrieved from Web Science Core Collection (WoSCC) database. CiteSpace, VOSviewer, R software (version 4.3.0) bibliometrix package, OALM platform, other tools were used analyses.The growth papers this topic can be divided into two stages: before after 2006. Overall, relevant in line with Price's curve. Subrata Ghosh Antonio Gasbarrini are authors highest academic field, Lee D.'s results widely recognized by researchers field. Among 72 countries involved study, United States contributed most, while China developed rapidly regard being area. From regional perspective, institutions North America, Europe, East Asia have made most significant contributions closest cooperation. 1074 articles included influential ones tended consider mechanism effect perspective microbiome. Multiple keyword analysis mutual verification. The showed that NF-κB, Mediterranean diet, fatty acids, fecal microbiota, etc., focus trends current research.A Mediterranean-like pattern may good habit patients. Carbohydrates, inulin-type fructans closely IBD. Fatty acid, gut oxidative stress, endoplasmic reticulum stress hot topics will emerging trends.

Language: Английский

Citations

7
The influences of extraction methods on the chemical constituents of Lyonia ovalifolia (wall.) Drude and intracellular protective effects based on metabolomics analysis DOI
Chunyan Li, Mengcheng Li,

Zhenhao Zhao

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 456, P. 140031 - 140031

Published: June 12, 2024

Language: Английский

Citations

2