Traditional Chinese Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 3241 - 3247
Published: Jan. 1, 2024
Language: Английский
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155360 - 155360
Published: Jan. 13, 2024
Language: Английский
Citations
8
Antioxidants, Journal Year: 2023, Volume and Issue: 12(9), P. 1712 - 1712
Published: Sept. 2, 2023
Gastric cancer (GC) is the fifth most common worldwide and makes up a significant component of global burden. Helicobacter pylori (H. pylori) influential risk factor for GC, with International Agency Research on Cancer classifying it as Class I carcinogen GC. H. has been shown to persist in stomach acid decades, causing damage stomach’s mucosal lining, altering gastric hormone release patterns, potentially function. Epidemiological studies have that eliminating reduces metachronous cancer. Evidence shows various molecular alterations are present precancerous lesions associated an infection. However, although can cause oxidative stress-induced cancer, antioxidants being treatment exact mechanism underlying GC etiology not fully understood. This review provides overview recent research exploring pathophysiology pylori-induced stress antioxidant supplements reduce or even eliminate occurrence.
Language: Английский
Citations
17
Phytomedicine, Journal Year: 2024, Volume and Issue: 134, P. 155988 - 155988
Published: Aug. 26, 2024
Endometrial cancer (EC) as one of the most prevalent malignancies in female reproductive system, usually has a poor diagnosis and unfavorable health effects. Neferine (Nef), derived from edible medicinal lotus seed, been known for its functional activity; however, anti-cancer mechanism EC remains elusive.
Language: Английский
Citations
6
Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102752 - 102752
Published: Jan. 17, 2025
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106072 - 106072
Published: Feb. 1, 2025
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 21, 2025
Gastric cancer (GC) is a prevalent malignant neoplasm within the digestive system, accounting for approximately 740,000 deaths globally each year, significantly impacting patients' quality of life and survival rates. The objective this investigation was to elucidate expression patterns Hypoxia Endoplasmic Reticulum Stress-related Differentially Expressed Genes (HERSRDEGs) in GC their association with prognostic outcomes patients. Utilizing Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases, datasets were retrieved, standard normalization performed. Differential analysis conducted using DESeq2, while somatic mutations copy number variations examined maftools GISTIC2.0. Spearman's correlation assessed interplay between HERSRDEGs across datasets. Functional enrichment analyses carried out clusterProfiler Ontology (GO) Kyoto Encyclopedia Genomes (KEGG) pathways, alongside Set Enrichment Analysis (GSEA). A risk model obtained by utilizing univariate Cox regression R package. We employed RT-qPCR validate mRNA levels five genes that impact gastric human adenocarcinoma tissues. acquired data revealed 19 including ANGPT2, CXCL8, AURKA exhibiting significant variation controls. In analysis, total genes-ANGPT2, CD36, EGR1, NOX4, TLR2-emerged as statistically significant, correlating strongly overall survival. LASSO featuring NOX4 yielded score formula capable predicting patient outcomes. Furthermore, multivariate highlighted RiskScore, age stage predictors. immune infiltration notable differences populations cells, such Natural Killer cells T-helper when comparing high-risk low-risk groups. conclusion, elucidates involvement progression potential biomarkers.
Language: Английский
Citations
0
Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12
Published: Feb. 25, 2025
The incidence of Poorly cohesive carcinoma (PCC) has steadily risen in recent years, posing a significant clinical challenge. To reveal the anti-tumor effects Jianpi Yangzheng Xiaozheng granule (JPYZXZ) PCC, an initial investigation was performed using CCK-8, colony formation, scratch, and transwell assays. This followed by network pharmacology studies to gain deeper understanding JPYZXZ's impact on gastric cancer (GC). Then reactive oxygen species (ROS), Fe2+, malondialdehyde (MDA), glutathione (GSH), Oil Red O staining, BODIPY493/503, triglyceride (TG), cholesterol (TC) assay kits western blot (Wb) analysis were applied exam regulatory JPYZXZ ferroptosis lipid metabolism. Additionally, molecular docking Wb used further investigate mechanisms PCC. Finally, vivo animal conducted. results show that can inhibit proliferation migration PCC cell. It increases levels ROS, MDA, while declining content GSH, TC, TG, droplet accumulation within cellular compartments. indicates negatively regulate expression proteins, including peroxidase 4 (GPX4), cystine/glutamate antipoter SLC7A11 (xCT), fatty acid synthase (FASN), acetyl coenzyme A carboxylase 1 (ACC1). Furthermore, ferrostatin-1 (fer-1) is able reverse aforementioned markers Molecular analyses exhibits favorable binding affinity towards Stearoyl-Coenzyme desaturase (SCD1). Mechanism demonstrate capable down-regulating expressions proteins like SCD1, β-catenin, GPX4, xCT, which analogous SCD1 knockdown application inhibitor A939572. Nevertheless, when knocked down, unable downregulate these proteins. Animal have corroborated vitro tumor-inhibiting JPYZXZ. Therefore, this study offers first evidence inhibits progression orchestrating altering metabolism, mediated SCD1/Wnt/β-catenin pathway.
Language: Английский
Citations
0
Medicine, Journal Year: 2024, Volume and Issue: 103(5), P. e36458 - e36458
Published: Feb. 2, 2024
This study aimed to elucidate the potential causative links between inflammatory biomarkers and gastric cancer risk via a two-sample Mendelian randomization approach. Leveraging genome-wide association (GWAS) data, we conducted analysis. Instrumental variable selection for markers – namely, tissue factor, monocyte chemotactic protein-1, E-selectin, interleukin 6 receptor, fatty acid-binding protein 4 was informed by SNP data from IEU database. Strongly associated SNPs served as instrumental variables. We applied suite of statistical methods, including Inverse Variance Weighted (IVW), Median Estimator (WME), MR-Egger, mode-based estimates, compute odds ratios (ORs) that articulate impact these on susceptibility. The IVW method revealed receptor inversely correlated with progression (OR = 0.86, 95% CI 0.74–0.99, P .03), whereas found elevate 1.21, 1.05–1.39, .03). variables comprised 5, 4, 7, 2, 3 respectively. Convergent findings WME, analyses corroborated associations. Sensitivity checks, heterogeneity, horizontal pleiotropy assessments, leave-one-out diagnostics, affirmed robustness reliability our instruments across diverse malignancy tissues without substantial bias. Our research suggests potentially mitigates, while may contribute pathogenesis (GC). Unraveling intricate biological interplay inflammation oncogenesis offers valuable insights preemptive strategies therapeutic interventions in management.
Language: Английский
Citations
2
Chinese Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: July 23, 2024
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 21, 2024
Endoplasmic reticulum (ER) homeostasis is essential for maintaining human health, and once imbalanced, it will trigger endoplasmic stress (ERS), which participates in the development of digestive system tumors other diseases. ERS has dual effect on tumor cells, activating adaptive responses to promote survival or inducing apoptotic pathways accelerate cell death tumor. Recent studies have demonstrated that Chinese botanical drug extracts can affect process by regulating exert anticancer effects. This article summarizes intervention recent years, as reference combined treatment with modern medicine.
Language: Английский
Citations
1