Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Fibroblast
activation
protein
(FAP),
predominantly
expressed
in
activated
fibroblasts,
plays
a
key
role
inflammatory
bone
diseases,
but
its
periodontitis
remains
unclear.
Accordingly,
this
study
identified
positive
association
between
FAP
levels
and
susceptibility
using
Mendelian
randomization
analysis.
Human
mouse
tissues
show
elevated
reduced
osteolectin
(OLN),
an
endogenous
inhibitor,
indicating
FAP/OLN
imbalance.
Single-cell
RNA
sequencing
revealed
gingival
fibroblasts
(GFs)
as
the
primary
OLN
source,
with
periodontitis-associated
GFs
showing
increased
reactive
oxygen
species,
cellular
senescence,
mTOR
pathway
activation.
Rapamycin
treatment
restored
balance
GFs.
Recombinant
pro-inflammatory
cytokine
secretion
osteoclast
differentiation
macrophages,
exacerbating
periodontal
damage,
whereas
inhibition
macrophage
inflammation,
collagen
degradation,
resorption
experimental
periodontitis.
Therefore,
senescent
drive
imbalance
through
activation,
contributing
to
progression.
Consequently,
targeting
may
offer
promising
therapeutic
strategy
for
Antioxidants,
Journal Year:
2024,
Volume and Issue:
14(1), P. 38 - 38
Published: Dec. 31, 2024
Oxidative
stress
plays
a
pivotal
role
in
the
pathogenesis
and
progression
of
cardiovascular
diseases
(CVDs).
This
review
focuses
on
signaling
pathways
oxidative
during
development
CVDs,
delving
into
molecular
regulatory
networks
underlying
various
disease
stages,
particularly
apoptosis,
inflammation,
fibrosis,
metabolic
imbalance.
By
examining
dual
roles
influences
sex
differences
levels
susceptibility,
this
study
offers
comprehensive
understanding
diseases.
The
integrates
key
findings
from
current
research
three
ways.
First,
it
outlines
major
CVDs
associated
with
their
respective
pathways,
emphasizing
stress’s
central
pathology.
Second,
summarizes
protective
effects,
mechanisms
action,
animal
models
antioxidants,
offering
insights
future
drug
development.
Third,
discusses
applications,
advantages,
limitations,
potential
targets
gene
therapy
providing
foundation
for
novel
therapeutic
strategies.
These
tables
underscore
systematic
integrative
nature
while
theoretical
basis
precision
treatment
CVDs.
A
contribution
is
differential
effects
across
different
stages
addition
to
proposal
innovative,
multi-level
intervention
strategies,
which
open
new
avenues
system.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(5), P. e0304713 - e0304713
Published: May 31, 2024
Argentatins
are
secondary
metabolites
synthesized
by
guayule
(
Parthenium
argentatum
A.
Gray)
with
numerous
potential
medical
applications.
In
addition
to
inhibiting
insect
growth,
they
endowed
several
pharmacological
properties
including
antimicrobial
and
antitumorigenic
activity.
However,
their
as
immunomodulators
remains
unexplored.
The
aim
of
the
present
study
was
investigate
whether
argentatins
can
modulate
function
immune
system.
Human
mesenchymal
stem
cells
were
treated
production
anti-
proinflammatory
cytokines
evaluated.
effect
on
polarization
CD4+
T-lymphocytes
macrophages
also
assessed.
Results
demonstrated
that
cellular
phenotypes,
Th2
lymphocytes
M1
macrophages.
These
findings
suggest
promising
therapeutic
agents
in
autoimmune
or
allergic
diseases,
open
new
perspectives
for
investigation
response
development
more
targeted
effective
immunomodulatory
therapies.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
21(11)
Published: Aug. 10, 2024
The
aberrant
activation
of
NLRP3
inflammasomes
is
intricately
linked
to
various
inflammatory
diseases.
In
this
study,
we
present
the
discovery
and
optimization
a
series
inflammasome
inhibitors
based
on
pterostilbene
skeleton.
All
compounds
underwent
screening
evaluate
their
inhibitory
effects
LPS/Nigericin-induced
IL-1β
secretion
anti-cellular
pyroptosis.
Most
exhibit
good
biological
activity
cellular
safety,
with
compound
D20
showing
most
prominent
activity.
Preliminary
mechanism
studies
suggest
that
may
affect
assembly
by
targeting
protein,
thereby
inhibiting
inflammasomes.
in
vivo
anti-inflammatory
demonstrated
significant
therapeutic
effect
DSS-induced
acute
colitis
model
mice.
This
work
has
important
reference
significance
for
development
drugs
The Tohoku Journal of Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Three
or
more
consecutive
spontaneous
pregnancy
losses
are
the
hallmark
of
recurrent
abortion
(RSA)
as
a
complex
challenge
in
reproductive
health,
requiring
comprehensive
understanding
contributing
factors.Since
balanced
immune
responses
essential
for
successful
pregnancy.Disruptions
may
be
cause
unfavorable
outcomes
like
RSA.Of
Note,
Following
RSA,
immunopathological
assessment
placental
implantation
site
markedly
showed
decidual
inflammation,
leading
to
hypothesize
that
RSA
is
disorder
with
an
inflammatory
etiology.Thus,
indepth
knowledge
how
cells
contribute
lead
discovery
novel
therapeutic
approaches
prevention
and/or
treatment
RSA.Numerous
studies
have
investigated
relationships
between
and
different
cells,
including
B
T
dendritic
macrophages.Macrophages
present
at
fetomaternal
interface
throughout
pregnancy,
they
beneficial
processes
embryonic
development,
formation,
embryo
implantation,
delivery.Macrophages
classified
typically
activated
(M1,
role),
alternatively
(M2,
characterized
by
anti-inflammatory
role).Plants
rich
supply
strong
bioactive
components
can
polarize
macrophages
toward
M1
pro-inflammatory
state
M2
phenotype.This
review
focuses
on
potential
role
derived
plantnatural
influencing
macrophage
polarization
resulting
management
RSA.
Natural Product Communications,
Journal Year:
2024,
Volume and Issue:
19(9)
Published: Sept. 1, 2024
Postmenopausal
osteoporosis
(PMOP)
is
an
important
part
of
primary
osteoporosis,
and
the
current
clinical
treatment
program
for
PMOP
easily
limited
by
side
effects
adverse
reactions,
so
it
particularly
to
seek
more
efficient,
safe,
economical
drug
PMOP.
In
recent
years,
with
change
disease
mode
gradual
deepening
Traditional
Chinese
medicine
(TCM)
research
on
PMOP,
a
review
literature
reveals
that
there
huge
number
studies
use
TCM
in
but
are
no
relevant
systematic
rules
its
formulas
specific
mechanisms
which
core
drugs
exert
their
therapeutic
effects.
Therefore,
this
study,
we
collected
total
141
used
clinicians
treat
statistically
analyzed
high-frequency
medications,
Four
Qi,
Five
Flavors,
meridians,
efficacies,
medications
based
association
rules,
were
Rehmanniae
Radix
Praeparata,
Epimedium,
Eucommia
ulmoides,
Rhizoma
Drynariae,
Angelica
sinensis,
Achyranthes,
Astragalus
propinquus,
Psoralen,
Cornus
officinalis
licorice.
A
87
pairs
obtained
from
correlation
analysis,
8
groups
potential
combination
4
new
prescriptions
derived
cluster
analysis.
Subsequently,
network
pharmacological
analysis
was
conducted
obtain
173
active
ingredients
drugs,
including
kaempferol,
β-sitosterol,
quercetin,
etc.
298
targets
action,
MAPK3,
STAT1,
HSP90AA1,
170
signaling
pathways
AGE-RAGE,
PI3
K/Akt,
TNF,
HIF-1
others.
The
molecular
docking
results
showed
11
key
had
stable
binding
target
targets.
This
study
mainly
“reinforcing
liver
kidney,
warmly
invigorating
spleen
stomach,
activating
blood
resolving
stasis.”
Core
therapy
comprehensive
intervention
through
multi-component,
multi-target,
multi-pathway
approaches.
minimum
energies
between
calculated
shows
have
good
activities
targets,
proving
predictions
reliable.
future,
will
provide
certain
medication
basis
data
support
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(23)
Published: Dec. 1, 2024
ABSTRACT
The
interaction
between
the
receptor
activator
of
nuclear
factor‐κB
ligand
(RANKL)
and
its
RANK
is
known
to
regulate
osteoclastogenesis
in
bone
remodelling
has
become
an
important
therapeutic
target
for
treatment
osteoporosis.
Stephanine
(SA),
isoquinoline
aporphine‐type
alkaloid
isolated
from
Stephania
plants,
possesses
excellent
anti‐inflammatory
effects
can
be
used
rheumatoid
arthritis
treatment.
However,
specific
role
osteoporosis
remains
unknown.
In
this
study,
we
investigated
influence
SA
on
RANKL‐stimulated
RAW
264.7
cells
ovariectomised
(OVX)
mouse
model
elucidated
underlying
molecular
mechanism.
vitro,
bind
RANKL
with
K
D
values
3.7
76.47
μM,
respectively,
disrupt
RANKL–RANK
interaction,
which
inhibits
RANK–tumour
necrosis
factor
associated
6
(TRAF6)
binding
signalling
pathways
activation,
downregulates
expression
key
osteoclastogenesis‐related
regulatory
factors
osteoclast
precursors,
ultimately
suppresses
differentiation
activation.
vivo,
significantly
ameliorated
loss
through
inhibiting
OVX
mice
because
decreased
number
osteoclasts
increased
trabecular
area.
markedly
inhibited
serum
levels
tartrate‐resistant
acid
phosphatase
5b
(TRACP‐5b),
c‐telopeptide
type
I
collagen
(CTX‐I),
RANKL,
whereas
it
that
osteoprotegerin
(OPG)
mice.
Additionally,
strikingly
downregulated
OVX‐induced
osteoclast‐specific
genes
proteins.
Taken
together,
study
effectively
protect
against
by
suppressing
via
inhibition
supports
potential
application
as
a
natural
agent
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Fibroblast
activation
protein
(FAP),
predominantly
expressed
in
activated
fibroblasts,
plays
a
key
role
inflammatory
bone
diseases,
but
its
periodontitis
remains
unclear.
Accordingly,
this
study
identified
positive
association
between
FAP
levels
and
susceptibility
using
Mendelian
randomization
analysis.
Human
mouse
tissues
show
elevated
reduced
osteolectin
(OLN),
an
endogenous
inhibitor,
indicating
FAP/OLN
imbalance.
Single-cell
RNA
sequencing
revealed
gingival
fibroblasts
(GFs)
as
the
primary
OLN
source,
with
periodontitis-associated
GFs
showing
increased
reactive
oxygen
species,
cellular
senescence,
mTOR
pathway
activation.
Rapamycin
treatment
restored
balance
GFs.
Recombinant
pro-inflammatory
cytokine
secretion
osteoclast
differentiation
macrophages,
exacerbating
periodontal
damage,
whereas
inhibition
macrophage
inflammation,
collagen
degradation,
resorption
experimental
periodontitis.
Therefore,
senescent
drive
imbalance
through
activation,
contributing
to
progression.
Consequently,
targeting
may
offer
promising
therapeutic
strategy
for
