Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 27, 2023
Abstract
Ulcerative
colitis
(UC)
is
a
chronic,
relapsing
inflammatory
disorder
of
the
gastrointestinal
tract.
Programmed
cell
death
(PCD),
such
as
PANoptosis
and
autophagy,
involved
in
various
inflammation-
immune-related
diseases.
This
study
aimed
to
examine
molecular
signature
associated
immune
infiltration
PANoptosis-
autophagy-related
differentially
expressed
genes
(DEGs)
UC.
Ten
PANoptosis-related
hub
DEGs,
including
PDGFRB,
TIMP1,
MMP2,
CD44,
TIMP2,
TGFB2,
IL6,
TIMP3,
IL1B,
HGF,
four
CCL2,
TGFB1,
PPARG,
CXCR4,
were
identified.
These
with
chemotaxis,
wound
healing
positive
regulation
MAPK
cascade.
Immune
analysis
revealed
UC
patients
exhibited
higher
immunocytes
these
closely
related
infiltrations.
Through
machine
learning
algorithms,
five
key
candidate
genes,
showed
good
diagnostic
performance
distinguishing
from
healthy
individuals.
Furthermore,
highly
fibroblasts
(IAFs)
by
single-cell
sequencing
analysis.
The
expression
levels
significant
differences
colon
mucosa
patients.
Our
findings
indicated
that
autophagy
or
crosstalk
between
them
might
be
implicated
dysregulation
via
regulating
specific
cells
IAFs
interacting
signals
chemotaxis
signaling
pathways.
Zeitschrift für Phytotherapie,
Journal Year:
2024,
Volume and Issue:
45(01), P. 41 - 47
Published: Feb. 1, 2024
Sanguisorba
officinalis
L.
ist
eine
traditionell
genutzte
Arzneipflanze
aus
der
Familie
Rosaceae.
Das
Kraut
und
die
Wurzeln
enthalten
ein
breites
Spektrum
phenolischer
terpenoider
Inhaltsstoffe
mit
vor
allem
entzündungshemmenden
antiinfektiven
Wirkungen.
Die
Wurzeldroge
spielt
in
Traditionellen
Chinesischen
Medizin
zur
Immunmodulation,
Wundbehandlung
Therapie
von
Infektionen
wichtige
Rolle,
wobei
sich
diese
Indikationen
denen
Europäischen
teilweise
überschneiden.
Trotz
langen
therapeutischen
Verwendung
klinische
Studienlage
gegenwärtig
unbefriedigend.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 27, 2023
Abstract
Ulcerative
colitis
(UC)
is
a
chronic,
relapsing
inflammatory
disorder
of
the
gastrointestinal
tract.
Programmed
cell
death
(PCD),
such
as
PANoptosis
and
autophagy,
involved
in
various
inflammation-
immune-related
diseases.
This
study
aimed
to
examine
molecular
signature
associated
immune
infiltration
PANoptosis-
autophagy-related
differentially
expressed
genes
(DEGs)
UC.
Ten
PANoptosis-related
hub
DEGs,
including
PDGFRB,
TIMP1,
MMP2,
CD44,
TIMP2,
TGFB2,
IL6,
TIMP3,
IL1B,
HGF,
four
CCL2,
TGFB1,
PPARG,
CXCR4,
were
identified.
These
with
chemotaxis,
wound
healing
positive
regulation
MAPK
cascade.
Immune
analysis
revealed
UC
patients
exhibited
higher
immunocytes
these
closely
related
infiltrations.
Through
machine
learning
algorithms,
five
key
candidate
genes,
showed
good
diagnostic
performance
distinguishing
from
healthy
individuals.
Furthermore,
highly
fibroblasts
(IAFs)
by
single-cell
sequencing
analysis.
The
expression
levels
significant
differences
colon
mucosa
patients.
Our
findings
indicated
that
autophagy
or
crosstalk
between
them
might
be
implicated
dysregulation
via
regulating
specific
cells
IAFs
interacting
signals
chemotaxis
signaling
pathways.
