Protective effect of orientin on diabetic nephropathy in rat models of high-fat diet and streptozotocin-induced diabetes

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

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Neuroprotective Effects of Myrtle Berry By-Product Extracts on 6-OHDA-Induced Cytotoxicity in PC12 Cells

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 88 - 88

Published: Jan. 13, 2025

The rising global focus on healthy lifestyles and environmental sustainability has prompted interest in repurposing plant-based by-products for health benefits. With increasing life expectancy, the incidence of neurodegenerative diseases—characterized by complex, multifactorial mechanisms such as abnormal protein aggregation, mitochondrial dysfunction, oxidative stress, inflammation—continues to grow. Medicinal plants, with their diverse bioactive compounds, offer promising therapeutic avenues conditions. Myrtus communis L., a Mediterranean plant primarily used liquor production, generates significant waste rich antioxidant anti-inflammatory properties. This study explores neuroprotective potential berry cellular model neurodegeneration. Using PC12 cells exposed 6-hydroxydopamine (6-OHDA), we assessed cell viability via MTT assay measured reactive oxygen species (ROS) production using DCFDA fluorescence. Additionally, analyzed expression genes linked stress neuronal function, including AChE, PON2, Grin1, Gabrd, c-fos, RT-PCR. Our findings reveal that extract significantly protects against 6-OHDA-induced cytotoxicity, reduces ROS levels, modulates key stress-related genes, underscoring its agent. These results highlight promise extracts mitigating processes, paving way future interventions.

Language: Английский

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ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF STEVIA REBAUDIANA LEAF EXTRACT IN DIABETIC RATS

FUDMA Journal of Sciences, Journal Year: 2025, Volume and Issue: 9(1), P. 301 - 306

Published: Jan. 31, 2025

This study explores the antioxidant and anti-inflammatory effects of Stevia rebaudiana aqueous leaf extract in alloxan-induced diabetic male Wistar rats. Thirty rats, comprising six normoglycemic controls (NC) twenty-four rats were used. The divided into four groups (n = 6 each): DC, administered distilled water; DGL, treated with glibenclamide; DSR100 DSR200, 100 200 mg/kg S. extract, respectively. Treatments daily via gavage for 15 days. After days, animals fasted overnight, euthanized by cervical dislocation, blood samples collected serum analyses. Body weight, liver fasting glucose (FBG), malondialdehyde (MDA) level monitored. Antioxidant enzyme activitiessuperoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)were also measured, alongside levels pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor- (TNF-), cytokine interleukin-10 (IL-10). findings revealed that significantly reduced MDA enhanced activities enzymes (SOD, CAT, GPx) Significant (p<0.05) improvements FBG, liver-to-body weight ratio, profiles observed DSR200 compared DC. Specifically, decreased IL-1 TNF- while elevating IL-10 level. These dose-dependent, dose showing most pronounced benefits. In conclusion, demonstrates robust activities, effectively attenuating oxidative stress-induced inflammatory responses

Language: Английский

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A comprehensive review on the potential applications of medicine Polygonatum species in the food sector

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104116 - 104116

Published: April 17, 2024

Language: Английский

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Dietary Polyphenols and Gut Microbiota Cross-Talk: Molecular and Therapeutic Perspectives for Cardiometabolic Disease: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9118 - 9118

Published: Aug. 22, 2024

The intricate interplay between the gut microbiota and polyphenols has emerged as a captivating frontier in understanding potentially harnessing therapeutic potential of these bioactive compounds. Phenolic compounds, renowned for their antioxidant, anti-inflammatory, antidiabetic, anticancer properties, are subject to transformations within milieu, where diverse microbial ecosystem exerts profound effects on metabolism bioavailability. Conversely, exhibit remarkable capacity modulate composition activity microbiota, fostering bidirectional relationship that extends beyond mere nutrient processing. This symbiotic interaction holds significant implications human health, particularly cardiometabolic diseases such diabetes mellitus, metabolic-dysfunction-associated steatotic liver disease, cardiovascular disease. Through comprehensive exploration molecular interactions, this narrative review elucidates reciprocal dynamics polyphenols, unveiling novel avenues intervention disorders. By unravelling cross-talk two entities, underscores multifaceted roles overall health pivotal role modulation promising strategy mitigating burden diseases.

Language: Английский

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Hypoglycemic activity in vivo and in vitro of the Lotus (Nelumbo nucifera Gaertn.) seed skin (testa) phenolic-rich extracts

Food Chemistry X, Journal Year: 2024, Volume and Issue: 22, P. 101282 - 101282

Published: March 16, 2024

Lotus (Nelumbo nucifera Gaertn.) seed, a traditional Chinese herbal medicine, exhibits good hypoglycemic activities. However, the bioactive components that are responsible for biological effects and their underlying mechanisms remain obscure. This study aimed to identify of lotus seed skin phenolic-rich extract (LSSE) investigate α-glucosidase inhibitory activity. In vivo showed LSSE could significantly decrease fasting blood glucose levels area under curves with dose-dependent manners in diabetes mellitus mice. And activity was decreased by 39.4% after intervention LSSE. The results also demonstrated possessed up 77.53% rat intestinal maltase general sucrase isomaltase A total 38 phenolic compounds were first quantified Molecular docking analysis further revealed bind hydrogen bonding Van der Waals hydrophobic interactions. These indicate potential use natural functional foods.

Language: Английский

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Apple Polyphenol Mitigates Diabetic Nephropathy via Attenuating Renal Dysfunction with Antioxidation in Streptozotocin-Induced Diabetic Rats

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 130 - 130

Published: Jan. 23, 2025

Diabetic nephropathy (DN) is a major cause of morbidity and mortality among patients with diabetes mellitus (DM). Studies have highlighted the critical role reactive oxygen species (ROS) in pathogenesis DM its complications. Apple polyphenol (AP) has demonstrated antioxidant properties various models. In this study, we investigated effects AP on DN rat model. Type 1 was induced Sprague–Dawley rats via single intraperitoneal injection streptozotocin (65 mg/kg) (n = 8). Rats blood glucose levels exceeding 250 mg/dL were treated at dosages 0.5%, 1%, or 2% (w/w) drinking water for 10 weeks. administration significantly improved early-stage markers, including reductions urea nitrogen-to-creatinine ratio urinary albumin-to-creatinine (ACR), dose-dependent manner. treatment also lowered triglyceride reduced lipid peroxidation kidney tissues. Histological analysis revealed that attenuated renal hydropic change, glomerular basement membrane thickening, restored mitochondrial morphology diabetic rats. Additionally, upregulation transforming growth factor-beta (TGF-β) observed by treatment. H2O2-stimulated mesangial cells, ROS levels, accompanied reduction TGF-β expression. These findings suggest exerts protective against improving function mitigating oxidative stress, indicating potential as nutraceutical supplement slowing progression.

Language: Английский

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A sustainable technology for enhancing the oxidative stability of edible oils using jackfruit (Artocarpus heterophyllus lam.) peel extract as a natural antioxidant

Food Chemistry, Journal Year: 2025, Volume and Issue: 485, P. 144564 - 144564

Published: April 29, 2025

Language: Английский

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Investigation of Antioxidant, Antidiabetic, and Antiglycation Properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. Extracts from Taza, Morocco

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100912 - 100912

Published: Feb. 1, 2025

Language: Английский

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Comparative profiling of secondary metabolites and antidiabetic properties of Anogeissus leiocarpus (DC.) Guill. &amp; Perr. (Combretaceae) extracts

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Background: Diabetes mellitus is a chronic metabolic condition which can result in severe long-term complications, and current treatments often have significant side effects. As result, there growing interest identifying novel α-amylase α-glucosidase inhibitors with improved safety profiles. Natural products emerged as promising source of such compounds. In this study, we investigated the antidiabetic potential solvent extracts phenolic compounds from Anogeissus leiocarpus (DC.) Guill. & Perr. Methods: Dried leaves stem bark were extracted using aqueous absolute ethanol, yielding ALE, ASE, ELE, ESE. We assessed their TPC, TFC, antioxidant capacity. The efficacy these HPLC-identified was evaluated through in vitro computational analyses inhibition. Results: ASE ALE demonstrated high polyphenol flavonoid content, along strong dose-dependent activity (FRAC, TAC, DPPH, NO scavenging). ASE highest inhibition, comparable to metformin (p > 0.05). Molecular docking analysis showed interactions between both α-glucosidase, binding affinities metformin. Notably, rutin exhibited scores -7.736 -7.098 kcal/mol for respectively, outperforming (-4.305 -4.094 kcal/mol). Conclusion: These findings suggest that A. its hold promise potent safer diabetes treatment.

Language: Английский

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