European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 985, P. 177122 - 177122
Published: Nov. 10, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 14, 2024
In the past 11 years, there has been a surge in studies exploring regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, significant gap persists comprehensive scientometric analysis and scientific mapping research, especially tracking evolution, primary contributors, emerging research focal points. This study aims to comprehensively update advancements targeting ferroptosis with various TCMs during previous years. The data, covering period from 1 January 2012, 30 November 2023, were retrieved Web Science database. For in-depth visualized analyses, series advanced analytical instruments employed. findings highlight China’s predominant role, accounting for 71.99% total publications significantly shaping this domain. Noteworthy productivity was observed at institutions, including Guangzhou University Medicine, Chengdu Zhejiang University. Thomas Efferth emerged as foremost author within field, while Frontiers Pharmacology boasted highest publication count. pinpointed hepatocellular carcinoma, chemical drug-induced liver injury, mitochondrial diseases, acute kidney failure most critical disorders addressed realm. offers bibliometric evaluation, enhancing our understanding present status TCM therapy managing ferroptosis-related diseases. Consequently, it aids both seasoned researchers newcomers by accelerating access vital information fostering innovative concept extraction specialized field.
Language: Английский
Citations
10
Phytomedicine, Journal Year: 2025, Volume and Issue: 137, P. 156374 - 156374
Published: Jan. 5, 2025
Language: Английский
Citations
1
Journal of Diabetes Research, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Background: Shenlian (SL) decoction, a renowned traditional Chinese formula for diabetes mellitus, has also been employed to treat intestinal disorders. Previous studies have demonstrated the efficacy of SL decoction in regulating blood glucose and bacteria. Nevertheless, further analysis is required elucidate mechanistic link between decoction–mediated improvement function treatment Type 2 mellitus (T2DM). Methods: Firstly, active ingredients were sourced from Traditional Medicine System Pharmacology (TCMSP) database, with putative targets being predicted using same database. Secondly, Online Mendelian Inheritance Man (OMIM) GeneCards databases screen aforementioned that act on T2DM, protein–protein interaction (PPI) networks constructed accordance results. Thirdly, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses conducted Database Annotation, Visualization, Integrated Discovery (DAVID), which resulted comprehensive association T2DM modulation functions. Finally, effect lipopolysaccharide (LPS)‐related targets, as well markers, was validated through vivo experimentation. Results: A total 36 145 potential predicted. GO indicated principal biological processes by acted against responses LPSs, while KEGG identified nuclear factor kappa B (NF‐ κ B) signaling pathway toll‐like receptor key pathways involved. The experiments showed improved glycolipid metabolism indexes, inflammatory levels, LPS levels db/db mice. immunohistochemical results restored expression Occludin, Claudin‐1, ZO‐1 intestine inhibited 4 (TLR4), myeloid differentiation primary response gene 88 (MYD88), NF‐ both pancreas. Furthermore, it may influence short‐chain fatty acids (SCFAs) feces. Conclusions: This research investigated multigene pharmacological mechanism network pharmacology experiments. reverse inflammation inhibiting LPS‐related activation improving function.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 23, 2025
Objectives The therapeutic efficacy of Traditional Chinese Medicine (TCM) in modulating gut microbiota for diabetes treatment has garnered increasing scholarly attention. This study aims to meticulously examine current research trajectories and focal areas from 2004 2024, providing a foundational framework future inquiries. Methods A comprehensive search documents published between 2024 was conducted using the Web Science database. resulting data were analyzed visualized R software, VOSviewer, CiteSpace. Results included total 751 documents. From 2022, number annual publications showed continuous upward trend (2004: n = 1 2022: 159), 2023 (n 141) decreased slightly previous year. China emerged as leading country terms article 430). Additionally, United States played prominent role international collaborations. Frontiers Pharmacology 31) most frequently journal, while Nature 1,147) achieved highest citation count. Key identified keywords obesity, insulin resistance, inflammation, oxidative stress. Conclusion Three key focuses this domain include: effects active constituents TCM on via modulation, underlying mechanisms through which influences management, targeted regulation specific bacterial populations by diabetes.
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156491 - 156491
Published: Feb. 10, 2025
Language: Английский
Citations
0
Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(2)
Published: Feb. 1, 2025
ABSTRACT Sepsis induces severe multiorgan dysfunction, with the lungs being particularly susceptible to damage. This study reveals that Hmox1 inhibitors effectively activate FSP1/CoQ10/NADPH pathway, significantly enhancing autophagic activity while suppressing ferroptosis in alveolar epithelial cells, thereby alleviating lung injury septic mice. To identify key gene modules and regulatory factors associated sepsis‐induced injury, we analyzed public transcriptomic data, including bulk RNA‐seq datasets (GSE236391 GSE263867) a single‐cell (scRNA‐seq) data set (GSE207651). In vitro experiments were conducted using an LPS‐induced cell model evaluate effects of on viability, autophagy markers (LC3‐II/LC3‐I p62), ROS levels, intracellular iron content. Transmission electron microscopy was used observe mitochondrial structural changes. vivo, cecal ligation puncture (CLP)‐induced sepsis mouse established assess therapeutic inhibitors. included evaluating survival rates, histopathological scores, wet‐to‐dry weight ratios, myeloperoxidase (MPO) activity, inflammatory cytokine changes markers. The results demonstrated mitigate by modulating autophagy‐ferroptosis highlighting their potential as strategy for
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156574 - 156574
Published: Feb. 27, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 18, 2025
Trigonella foenum-graecum L. (HLB) exhibits promising pharmacological properties for the treatment of type 2 diabetic nephropathy (DN). This study aims to enhance understanding HLB's pharmacodynamic effects and elucidate mechanisms underlying its therapeutic potential in DN. The HLB were initially evaluated a murine DN model through oral administration an aqueous extract HLB. primary bioactive constituents subsequently identified using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS). Network pharmacology analysis was integrated these data uncover molecular targets Key renal metabolites profiled untargeted metabolomics, followed by metabolic pathway enrichment conducted MetaboAnalyst 6.0 platform, which facilitated identification relevant pathways modulates Finally, quantitative real-time polymerase chain reaction (QRT-PCR) Western blot (WB) techniques employed validate expression levels key genes proteins, thereby confirming Animal experiments indicated that significantly improved blood glucose regulation function while reducing oxidative stress abnormalities lipid metabolism mice. A total 34 compounds 159 as active components metabolomics revealed 61 critical metabolites, among PI3K-Akt-ERK signaling pathway-known be involved diabetes-was highlighted crucial pathway. QRT-PCR WB analyses demonstrated upregulated MAPK1, MAPK3, AKT1, PI3K. These results suggest may alleviate modulating metabolism. Its are likely mediated pathway, along upregulation PI3K expression. lays groundwork further investigations into action
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: April 10, 2025
Background Colon adenocarcinoma (COAD) remains a major global health challenge with poor prognosis despite advances in treatment, underscoring the need for new biomarkers. As novel mode of cell death, cuproptosis is thought to be potentially involved development cancer. However, particularly as role cuproptosis-related genes (CRGs) COAD and therapy unclear. Methods We analyzed RNA sequencing data from The Cancer Genome Atlas COAD, focusing on CRG expression patterns their clinicopathological correlations. Using Weighted Gene Co-expression Network Analysis (WGCNA) method, we identified gene module most strongly linked conducted functional enrichment analysis explore roles within this tumorigenesis. A prognostic risk model based four CRGs (ORC1, PTTG1, DLAT, PDHB) was developed stratify patients into high-risk low-risk groups, assessing overall survival, tumor microenvironment, mutational landscape differences. also evaluated therapeutic effects ferredoxin 1 (FDX1) elesclomol promoting HCT116 LoVo lines through various experiments, including proliferation, apoptosis assessment, mitochondrial membrane potential evaluation, DLAT lipoylation detection via Western blot. Results Certain showed different expressions versus normal tissues. WGCNA cuproptosis, crucial pathways like cycle regulation, citrate (TCA cycle), DNA replication. stratified high groups scores, revealing that had shorter survival distinct immune infiltration, while were more sensitive immunotherapy. Experimental results indicated FDX1 exerted an inhibitory effect its combination significantly reduced promoted apoptosis, increased lipoylation, lowered cells. Conclusion findings study provided perspective research biomarkers strategies value patients, laid theoretical foundation future clinical application CRGs.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 12, 2025
Language: Английский
Citations
0