Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations DOI Open Access

Lorena Ciumărnean,

Oliviu Florențiu Sârb, Nicu Cătălin Drăghici

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10909 - 10909

Published: Oct. 10, 2024

Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system. Brain plasticity, brain’s ability to adapt its structure function, plays a crucial role in mitigating MS’s impact. This paper explores potential benefits of lifestyle changes nutraceuticals on brain plasticity MS population. Lifestyle modifications, including physical activity dietary adjustments, can enhance upregulating neurotrophic factors, promoting synaptogenesis, reducing oxidative stress. Nutraceuticals, such as vitamin D, omega-3 fatty acids, antioxidants like alpha lipoic acid, have shown promise supporting health through anti-inflammatory neuroprotective mechanisms. Regular has been linked increased levels brain-derived factor improved cognitive function. Dietary interventions, caloric restriction intake polyphenols, also positively influence plasticity. Integrating these into management provide complementary approach traditional therapies, potentially improving neurological outcomes enhancing quality life for

Language: Английский

Optineurin restrains CCR7 degradation to guide type II collagen-stimulated dendritic cell migration in rheumatoid arthritis DOI Creative Commons

Wenxiang Hong,

Hongbo Ma,

Zhaoxu Yang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: 15(3), P. 1626 - 1642

Published: Feb. 11, 2025

Dendritic cells (DCs) serve as the primary antigen-presenting in autoimmune diseases, like rheumatoid arthritis (RA), and exhibit distinct signaling profiles due to antigenic diversity. Type II collagen (CII) has been recognized an RA-specific antigen; however, little is known about CII-stimulated DCs, limiting development of therapeutic interventions. In this study, we show that DCs display a preferential gene expression profile associated with migration, offering new perspective for targeting DC migration RA treatment. Then, saikosaponin D (SSD) was identified compound capable blocking CII-induced effectively ameliorating arthritis. Optineurin (OPTN) further revealed potential SSD target, Optn deletion impairing CII-pulsed without affecting maturation. Function analyses uncover OPTN prevents proteasomal transport ubiquitin-dependent degradation C-C chemokine receptor 7 (CCR7), pivotal migration. Optn-deficient reduced CCR7 expression, leading slower CII-surrounded environment, thus alleviating progression. Our findings underscore significance antigen-specific activation suggest crucial regulator CII-specific emerges promising drug target RA, potentially significant value management RA.

Language: Английский

Citations

0
On the Exploitation of Lignin Slow Pyrolysis Products DOI Creative Commons
Guido Busca, Elena Spennati, Matteo Borella

et al.

Energies, Journal Year: 2025, Volume and Issue: 18(4), P. 943 - 943

Published: Feb. 16, 2025

The potential of technical lignins as secondary raw materials is discussed. characteristics lignin pyrolysis, with particular emphasis on slow pyrolysis technologies, are briefly summarized. process, which can be self-sustained by burning the coproduced gas, primarily produce high-quality biochar in significant amounts, to used a fuel, reductant metallurgy, and an adsorbent catalyst component. Together, amounts bio-oil produced, rich guaiacols, commercial expensive chemicals produced today via petrochemical routes pharmacology, food chemistry, polymer etc. Such compounds, or itself, also converted hydrodeoxygenation into biofuels. A possible simplified flowsheet for process frame ligneocellulosics-based biorefinery proposed.

Language: Английский

Citations

0
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling DOI Creative Commons
Xiaoyu Shi,

Yixi He,

Maofa Ge

et al.

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract Demyelination is a common feature of numerous neurological disorders including multiple sclerosis and leukodystrophies. Although myelin can be regenerated spontaneously following injury, this process often inadequate, potentially resulting in neurodegeneration exacerbating dysfunction. Several drugs aimed at promoting the differentiation oligodendrocyte precursor cells (OPCs) have yielded unsatisfactory clinical effects. A recent study has shifted strategy pro-OPC towards enhancing myelinogenesis. In we identified pro-myelinating drug using zebrafish model. Five traditional Chinese medicine monomers gastrodin, paeoniflorin, puerarin, salidroside scutellarin were assessed by bath-application Tg (MBP:eGFP-CAAX) transgenic line 1–5 dpf. Among 5 monomers, only gastrodin exhibited significant pro-myelination activity. We showed that (10 µM) enhanced sheath formation (OL) maturation without affecting number OLs. Gastrodin markedly increased phosphorylation levels PI3K, AKT, mTOR primary cultured OLs via direct interaction with PI3K. Co-treatment PI3K inhibitor LY294002 (5 mitigated gastrodin-induced OL maturation. Furthermore, injection (100 mg·kg −1 ·d , i.p.) effectively facilitated remyelination lysophosphatidylcholine-induced demyelinating mouse model alleviated demyelination experimental autoimmune encephalomyelitis mice. These results identify as promising therapeutic agent for diseases highlight potential screening pro-myelinogenic pharmacotherapy.

Language: Английский

Citations

0
THE ROLE OF TRADITIONAL CHINESE MEDICINE IN ADDRESSING THE CHALLENGES OF CLOSTRIDIAL GAS GANGRENE: A MULTIFACETED APPROACH DOI

Pavithra Bharathy,

Punniyakoti T. Veeraveedu

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: unknown, P. 100198 - 100198

Published: March 1, 2025

Language: Английский

Citations

0
Steroidal saponins: a treasure trove of natural resources that require urgent development DOI
Zhiqiang Sun, Chunmei Zhong, Hongdan Zhang

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Language: Английский

Citations

0
Immunomodulatory Effects of Anadenanthera colubrina Bark Extract in Experimental Autoimmune Encephalomyelitis DOI Creative Commons
Karla Antunes Ramos,

Igor Gabriel Machado Soares,

Larissa M. A. Oliveira

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 8726 - 8740

Published: Aug. 10, 2024

This study aimed to evaluate the efficacy of ethanolic extract Anadenanthera colubrina in modulating immune response Experimental Autoimmune Encephalomyelitis (EAE) model. The dried bark was analyzed by ESI (+) Orbitrap-MS obtain a metabolite profile, demonstrating wide variety polyphenols, such as flavonoids and phenolic acids. Various parameters were evaluated, clinical signs, cytokines, cellular histopathology central nervous system (CNS). A. demonstrated significant positive effects attenuating signs pathological processes associated with EAE. beneficial treatment evidenced reduced levels pro-inflammatory IL1β, IL-6, IL-12, TNF, IFN-γ, notable decrease several cell profiles, including CD8+, CD4+, CD4+IFN-γ, CD4+IL-17+, CD11c+MHC-II+, CD11+CD80+, CD11+CD86+ CNS. In addition, histological analysis revealed fewer inflammatory infiltrates demyelination sites spinal cord mice treated compared control model group. These results showed, for first time, that exerts modulatory effect on processes, improving EAE, acute phase disease, which could be further explored possible therapeutic alternative.

Language: Английский

Citations

1
Obesity Control and Nutraceuticals in the Aid of Brain Plasticity in Multiple Sclerosis Patients DOI Open Access

Lorena Ciumărnean,

Oliviu Florențiu Sârb, Nicu Cătălin Drăghici

et al.

Published: July 24, 2024

Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system. Brain plasticity, brain's ability to adapt its structure function, plays a crucial role in mitigating MS's impact. This paper explores potential benefits of lifestyle changes nutraceuticals on brain plasticity MS patients. Lifestyle modifications, including physical activity dietary adjustments, can enhance upregulating neurotrophic factors, promoting synaptogenesis, reducing oxidative stress. Nutraceuticals, such as vitamin D, omega-3 fatty acids, antioxidants like alpha-lipoic acid, have shown promise supporting health through anti-inflammatory neuroprotective mechanisms. Regular has been linked increased levels brain-derived factor (BDNF) improved cognitive function. Dietary interventions, caloric restriction intake polyphenols, also positively influence plasticity. Integrating these into management could provide complementary approach traditional therapies, potentially improving neurological outcomes enhancing quality life for

Language: Английский

Citations

0
Exploring the Therapeutic Potential: Bioactive Molecules and Dietary Interventions in Multiple Sclerosis Management DOI Creative Commons
Gabriele Tancreda, Silvia Ravera, Isabella Panfoli

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(6), P. 5595 - 5613

Published: June 3, 2024

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system, etiology which still unclear. Its hallmarks are inflammation and axonal damage. As primarily impacting younger individuals, social cost MS high. It has been proposed that environmental factors, smoking, dietary habits acting on genetic susceptibility play role in MS. Recent studies indicate diet can significantly influence onset progression This review delves into impact natural bioactive molecules development explores interventions hold promise managing disease. Dietary patterns, including ketogenic Mediterranean diets, discussed. Theories about potential mechanistic associations beneath noted effects also proposed. Several components patterns demonstrated for significant However, extensive prospective clinical trials necessary to fully understand as modifiers

Language: Английский

Citations

0
Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations DOI Open Access

Lorena Ciumărnean,

Oliviu Florențiu Sârb, Nicu Cătălin Drăghici

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10909 - 10909

Published: Oct. 10, 2024

Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system. Brain plasticity, brain’s ability to adapt its structure function, plays a crucial role in mitigating MS’s impact. This paper explores potential benefits of lifestyle changes nutraceuticals on brain plasticity MS population. Lifestyle modifications, including physical activity dietary adjustments, can enhance upregulating neurotrophic factors, promoting synaptogenesis, reducing oxidative stress. Nutraceuticals, such as vitamin D, omega-3 fatty acids, antioxidants like alpha lipoic acid, have shown promise supporting health through anti-inflammatory neuroprotective mechanisms. Regular has been linked increased levels brain-derived factor improved cognitive function. Dietary interventions, caloric restriction intake polyphenols, also positively influence plasticity. Integrating these into management provide complementary approach traditional therapies, potentially improving neurological outcomes enhancing quality life for

Language: Английский

Citations

0