New advances in Traditional Chinese Medicine interventions for epilepsy: where are we and what do we know?

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 18, 2025

Abstract Epilepsy, one of the most common neurological diseases, affects more than 70 million people worldwide. Anti-seizure drugs targeting membrane ion channels or GABAergic neurotransmission are first choices for controlling seizures, whereas high incidence pharmacoresistance and adverse effects largely restrict availability current anti-seizure (ASDs). Traditional Chinese Medicine (TCM) has shown historical evidence-based therapeutic diseases including epilepsy. But until late 1990s, great efforts in both clinical experimental fields advanced TCM interventions epilepsy from practices to systematic neuropharmacological significance, show new lights on preferable management last decade. This review summarized advances applying (ranging herbal medicines their active ingredients other strategies such as acupuncture) epilepsy, followed by associated mechanism theories. The potential well its comorbidities turns somehow debatable hopeful. Finally, some prospects directions were proposed drive further translational research. future should aim at not only deriving specific anti-epileptic molecules but also illustrating precise mechanisms with assistance multifaceted tools.

Language: Английский

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Sleep promoting and omics exploration on probiotics fermented Gastrodia elata Blume

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: June 18, 2024

Abstract Fermenting Chinese medicinal herbs could enhance their bioactivities. We hypothesized probiotic-fermented gastrodia elata Blume (GE) with better potential to alleviate insomnia than that of unfermented, thus the changes in chemical composition and insomnia-alleviating effects mechanisms fermented GE on pentylenetetrazole (PTZ)-induced zebrafish were explored via high-performance liquid chromatography (HPLC) mass spectroscopy-coupled HPLC (HPLC-MS), phenotypic, transcriptomic, metabolomics analysis. The results demonstrated probiotic performed unfermented increasing content composition, reducing displacement, average speed, number apoptotic cells insomnia. Metabolomic investigation showed anti-insomnia effect was related regulating pathways actin cytoskeleton neuroactive ligand-receptor interactions. Transcriptomic reverse transcription qPCR (RT-qPCR) analysis revealed secondary fermentation (SFL) significantly modulated expression levels neurod1, msh2, msh3, recql4, ercc5, rad5lc, rev3l, which are mainly involved neuron differentiation DNA repair. Collectively, as a functional food, possessed for alleviation.

Language: Английский

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The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(11), P. 5107 - 5133

Published: Aug. 15, 2024

Abstract Central nervous system (CNS)‐related diseases have a high mortality rate, are serious threat to physical and mental health, always been an important area of research. Gastrodin, the main active metabolite Gastrodia elata Blume, used in Chinese medicine food, has wide range pharmacological effects, mostly related CNS disorders. This review aims systematically summarize discuss effects underlying mechanisms gastrodin treatment diseases, assess its potential for further development as lead drug both biomedicine traditional medicine. Studies on indicate that it may exert anti‐neurodegenerative, cerebrovascular protective, ameliorative diabetic encephalopathy, perioperative neurocognitive dysfunction, epilepsy, Tourette's syndrome, depression anxiety, sleep disorders through various mechanisms. To date, 110 products approved clinical use, but multicenter case–control studies relatively scarce. Preclinical confirmed can be treat CNS‐related However, concerns need addressed context likely non‐specific, assay interfering when is studied using vitro silico approaches, calling systematic assessment evidence date. High‐quality trials should priority evaluate therapeutic safety efficacy gastrodin. Further experimental research appropriate vivo models also needed, focusing neurodegenerative cerebral ischemic hypoxic brain damage caused by methamphetamine or heavy metals, epilepsy.

Language: Английский

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Genome-wide identification of carboxyesterase family members reveals the function of GeCXE9 in the catabolism of parishin A in Gastrodia elata

Plant Cell Reports, Journal Year: 2025, Volume and Issue: 44(2)

Published: Jan. 30, 2025

Language: Английский

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Investigation of quality control of Gastrodia elata using electrochemical fingerprint technology

International Journal of Electrochemical Science, Journal Year: 2024, Volume and Issue: 19(8), P. 100702 - 100702

Published: June 26, 2024

Gastrodia elata, a traditional Chinese medicinal herb, undergoes processing with ginger to enhance its therapeutic properties. This study investigated the impact of on quality control G. elata using electrochemical fingerprint technology and high-performance liquid chromatography (HPLC). The conditions were optimized, fingerprints raw ginger-processed samples compared. HPLC analysis revealed significant changes in contents gastrodin, parishin A, B after processing. exhibited distinct differences between samples, improved batch-to-batch consistency latter. Principal component hierarchical cluster demonstrated correlation results. findings highlight potential as complementary tool for comprehensive assessment elata. provides valuable insights into establishing standardized protocols strategies emphasizing importance combining multiple analytical techniques ensuring consistency, safety, efficacy herbal medicines.

Language: Английский

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Study on the chemical composition of Gegen-Tianma decoction and its absorbed constituents in rat plasma, brain based on UPLC-Q-TOF-MS and DESI-MSI

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 251, P. 116446 - 116446

Published: Aug. 24, 2024

Language: Английский

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Analysis of Key Volatile Components and Their Influencing Factors in the Production of Indigenous Gastrodia elata in Guizhou

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117513 - 117513

Published: Feb. 1, 2025

Language: Английский

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Gastrodin Mitigates Ketamine-Induced Inhibition of F-Actin Remodeling and Cell Migration by Regulating the Rho Signaling Pathway

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 649 - 649

Published: March 6, 2025

Background/Objects: Rho signaling plays a role in calcium-regulated cytoskeletal reorganization and cell movement, processes linked to neuronal function cancer metastasis. Gastrodia elata, traditional herbal medicine, can regulate glutamate-induced calcium influx PC12 cells influence by modulating cytoskeleton remodeling via the monoaminergic system signaling. This study investigates effects of gastrodin, key component on signaling, remodeling, migration B35 C6 cells. It also explores gastrodin’s impact prefrontal cortex Sprague Dawley rats. Methods: cells, rats were treated with ketamine, or both. The expression examined proteins from analyzed using immunoblotting. Immunofluorescent staining was applied detect phosphorylation RhoGDI1. F-actin stained phalloidin-488 staining. Cell Transwell wound-healing assays. Results: Gastrodin reversed ketamine-induced regulation mobility inhibition, condensation, modulation including GDP dissociation inhibitor 1 (RhoGDI1); family protein (Ras homolog member A (RhoA); division control 42 (CDC42); Ras-related C3 botulinum toxin substrate 1(Rac1)); rho-associated, coiled-coil-containing kinase (ROCK1); neural Wiskott–Aldrich syndrome (NWASP); myosin light chain 2 (MLC2); profilin1 (PFN1); cofilin-1 (CFL1) Similar modulations observed Conclusions: Our findings show that gastrodin counteracts disruptions dynamics, regulating components like RhoGDI1, ROCK1, MLC2, PFN1, CFL1. suggests potential as comprehensive regulator cellular

Language: Английский

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A Gastrodia elata polysaccharide for restoring intestinal immunocompromise

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141781 - 141781

Published: March 1, 2025

We here extracted a polysaccharide fragment from Gastrodia elata, characterized by main chain connected via (1 → 4)-α-D-Glcp bonds, with terminal α-D-Glcp-(1→) linked to the through O-6 of 4,6)-α-D-Glcp and O-3 3,4)-α-D-Glcp (SRGP). Both in vitro vivo experiments demonstrated that SRGP activates TLR4/NF-κB signaling pathway, exerting immunomodulatory effects alleviating cyclophosphamide (CTX)-induced intestinal mucosal damage mice. High-throughput 16S rRNA sequencing further revealed restores gut microbiota composition enhances abundance specific bacterial populations. Additionally, improves CTX-induced upregulating tight junction proteins, mitigating dysbiosis, regulating both overall microbial community levels bacteria.

Language: Английский

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Parishin A alleviates insomnia by regulating hypothalamic-pituitary-adrenal axis homeostasis and directly targeting orexin receptor OX2

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177498 - 177498

Published: March 1, 2025

Language: Английский

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