Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 5, 2024
Language: Английский
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 26, 2025
Lung cancer remains a major global health challenge and one of the leading causes cancer-related deaths worldwide. Despite significant advancements in treatment, challenges such as drug resistance, side effects, metastasis recurrence continue to impact patient outcomes quality life. In response, there is growing interest complementary integrative approaches care. Traditional Chinese medicine (TCM), with its long history, abundant clinical experience, holistic perspective individualized approach, has garnered increasing attention for role lung prevention management. This review provides comprehensive overview advances TCM covering theoretical foundation, treatment principles, experiences evidence supporting efficacy. We also provide systematic summary preclinical mechanisms, through which impacts cancer, including induction cell death, reversal inhibition modulation immune responses. Additionally, future prospects are discussed, offering insights into expanded application integration modern address this challenging disease.
Language: Английский
Citations
2
Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156591 - 156591
Published: March 6, 2025
Language: Английский
Citations
1
Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(6)
Published: May 21, 2024
Abstract Cancer is one of the major causes death worldwide, with more than 10 million deaths annually. Despite tremendous advances in health sciences, cancer continues to be a substantial global contributor mortality. The current treatment methods demand paradigm shift that not only improves therapeutic efficacy but also minimizes side effects conventional medications. Recently, an increased interest potential natural bioactive compounds several types has been observed. Ononin, referred as formononetin‐7‐O‐β‐d‐glucoside, isoflavone glycoside, derived from roots, stems, and rhizomes various plants. It exhibits variety pharmacological effects, including Antiangiogenic, anti‐inflammatory, antiproliferative, proapoptotic, antimetastatic activities. review presents thorough overview sources, chemistry, pharmacokinetics, role ononin affecting mechanisms involved cancer. discusses synergistic interactions other therapies. combined effect methods. Finally, safety studies, comprising both vitro vivo assessments ononin's anticancer activities, are described.
Language: Английский
Citations
6
World Journal of Gastrointestinal Surgery, Journal Year: 2024, Volume and Issue: 16(7), P. 2183 - 2193
Published: July 22, 2024
According to the theory of traditional Chinese medicine (TCM), spleen and stomach are basis acquired nature source qi blood biochemistry. After surgery chemotherapy, patients with colorectal cancer often develop deficiency syndrome, leading decreased immune function. Buzhong Yiqi decoction, a classic TCM prescription, has effect tonifying middle-jiao invigorating qi, boosting Yang, suppressing immune-related inflammation. Moreover, it is widely used in treatment syndrome.
Language: Английский
Citations
5
Molecules, Journal Year: 2025, Volume and Issue: 30(1), P. 188 - 188
Published: Jan. 5, 2025
More than 70% of cancer patients receive radiotherapy during their treatment, with consequent various side effects on normal cells due to high ionizing radiation doses despite tumor shrinkage. To date, many radioprotectors and radiosensitizers have been investigated in preclinical studies, but use has hampered by the toxicity or poor radiosensitization effects. Genistein is a naturally occurring isoflavone found soy products. It selectively sensitizes while protecting from radiation-induced damage, thus improving efficacy therapeutic outcomes reducing adverse protects its potent antioxidant effect that reduces oxidative stress mitigates apoptosis inflammation. Conversely, genistein increases radiosensitivity through specific mechanisms such as inhibition DNA repair, arrest cell cycle G2/M phase, generation reactive oxygen species (ROS), modulation apoptosis. These increase cytotoxicity radiation. Preclinical studies demonstrated models, breast, prostate, lung cancer. Despite limited clinical existing evidence supports potential radiotherapy. Future research should focus dosage optimization administration, exploration combination therapies, long-term trials establish benefits settings. Hence, unique ability improve could be promising strategy safety
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Language: Английский
Citations
0
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(2), P. 41 - 41
Published: Jan. 24, 2025
Nanoparticle-based X-ray radiosensitization strategies have garnered significant attention in recent years. However, the underlying mechanisms of remain incompletely understood. In this work, we explore influence K-edge effect absorption nanomaterials on sensitization. Due to alignment thulium (Tm) with Bremsstrahlung peak energy spectrum medical accelerators, following four different rare-earth varying Tm percentages were designed: NaTmF4, NaTm0.6Lu0.4F4, NaTm0.4Lu0.6F4, and NaLuF4. We evaluated ability generate secondary electrons reactive oxygen species (ROS) these nanoparticles. The radiosensitizing was through clonogenic assays. Our results showed that affected electron generation but did not significantly change ROS production. Nonetheless, NaTmF4 induced marginally more DNA damage U87 cells than other cell types. also exhibited superior efficacy against tumor cells. This shows play pivotal roles radiosensitization, which might be crucial improving cancer treatment enhanced radiation therapy outcomes.
Language: Английский
Citations
0
Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 17, 2025
Abstract Energy metabolism plays a pivotal role in cancer clinical treatment and has become an important means of diagnosis tumour progression. However, current research mostly focuses on changes metabolic products neglects the deeper mechanisms transcriptional regulation. This paper proposes new perspective, establishing comprehensive network that reveals interaction between transcription, which explores how affects progression through modifications, provides novel approach for optimizing strategies. viewpoint is conducive to overcoming bottlenecks promoting development drug combinations personalized medicine.
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 28, 2025
Introduction “Sweating,” a key step in the processing and production of Eucommiae Cortex (EC), which plays vital role formation medicinal quality EC. However, mechanism effect this traditional treatment herbs on is still unclear. Methods In study, high performance liquid chromatography (HPLC), UPLC/MS-based untargeted metabolomics high-throughput sequencing were applied to investigate dynamic changes main active ingredients, differential metabolites bacterial communities process “sweating” The samples prepared by stacking method, collected once day for five consecutive days. Results results showed that contents constituents, geniposidic acid (GPA), chlorogenic (CA), rutin (AU), pinoresinol diglucoside (PD) total flavonoids (TFS), increased significantly after steaming, followed slight decrease. Furthermore, 807 identified as crucial factors contributing metabolic alterations induced process. Microbial diversity analysis considerable microbiota characteristics, functional microorganisms before EC Gluconobacter, unclassified_c_Gammaproteobacteria, Pseudomonas, Pantoea, Pedobacter, Parecoccus , involved pathways other secondary leading significant alkaloids, amino related compounds, flavonoids, phenylpropanoids terpenoids. Discussion correlation network established between core communities, elucidates microbial regulation during sweating. These findings provide scientific foundation optimizing duration advancing control strategies through targeted community management.
Language: Английский
Citations
0
Separation Science Plus, Journal Year: 2025, Volume and Issue: 8(3)
Published: Feb. 28, 2025
ABSTRACT HuangqiGuizhiWuwu decoction (HGWD) possesses a complex and diverse chemical composition, rendering the identification of its components challenging. In this study, UPLC fingerprinting profile HGWD was elucidated method determining multiple in proposed. Common peaks were selected from 12 batches HGWD, Chinese herbal chromatographic fingerprint similarity evaluation system (2012) employed for analyses. The corresponding to common identified using UPLC‐Q‐TOF‐MS. Chemical analyses conducted evaluate quality different identify primary components. similarities profiles all > 0.98, with 15 confirmed divided into three categories, OPLS‐DA used cinnamic acid cinnamaldehyde as characteristic that caused differences. five which included albiflorin, paeoniflorin, calycosin‐7‐O‐β‐D‐glucoside, acid, cinnamaldehyde, exhibited good linear relationships average recovery rates relative standard deviations. This study established proposed simple, feasible, sensitive, reproducible content determination method. Moreover, our findings provide robust foundation standardization HGWD.
Language: Английский
Citations
0