Biomeditsinskaya Khimiya, Journal Year: 2024, Volume and Issue: 70(6), P. 381 - 393
Published: Jan. 1, 2024
The review summarizes recent achievements and future prospects in the use of chronobiotics for regulating circadian rhythms regulation. Special attention is paid to mechanisms' action, their classification, impact chemical interventions on biological clock. Chronobiotics defined as a diverse group compounds capable restoring disrupted functions, addressing challenges such irregular work schedules, artificial light exposure or ageing. categorizes these by pharmacological effects, molecular targets, structures, underlining ability enhance inhibit key components like CLOCK, BMAL1, PER, CRY. A particular focus placed therapeutic applications chronobiotics, including potential treating sleep disorders, metabolic issues, age-related rhythm disturbances, underscoring wide-ranging applicability health care. Chronobiotic have promising roles maintaining physiological rhythms, supporting healthy aging, enhancing personalised Given potential, are positioned significant avenue further clinical application, marking them crucial area ongoing research innovation.
Language: Английский