Effusol ameliorates ischemic stroke by targeting NLRP3 protein to regulate NLRP3 inflammasome-mediated pyroptosis DOI
Libin Xu, Siyu Li,

Jiaxin Qi

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156253 - 156253

Published: Nov. 25, 2024

Language: Английский

Recent advances in encapsulation of resveratrol for enhanced delivery DOI
Dilara Nur Dikmetaş,

Hande Yenipazar,

Aslı Can Karaça

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140475 - 140475

Published: July 16, 2024

Language: Английский

Citations

11
A quinolinyl resveratrol derivative alleviates acute ischemic stroke injury by promoting mitophagy for neuroprotection via targeting CK2α’ DOI
Libin Xu,

Yan Mi,

Qingqi Meng

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112524 - 112524

Published: June 22, 2024

Language: Английский

Citations

5
Promising Natural Remedies for Alzheimer’s Disease Therapy DOI Creative Commons

Amin Mahmood Thawabteh,

Aseel Wasel Ghanem, Sara AbuMadi

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 922 - 922

Published: Feb. 17, 2025

This study examines the intricacies of Alzheimer's disease (AD), its origins, and potential advantages various herbal extracts natural compounds for enhancing memory cognitive performance. Future studies into AD treatments are encouraged by review's demonstration effectiveness phytoconstituents that were extracted from a number plants. In addition to having many beneficial effects, such as improved cholinergic function, medicines also much less harmful, more readily available, easier use than other treatments. They pass without difficulty through blood-brain barrier (BBB). focused on substances their effects using academic databases identify peer-reviewed published between 2015 2024. According literature review, 66 isolated 21 distinct plants have shown efficacy, which could be encouraging future research therapies. Since most clinical trials produce contradictory results, suggests larger-scale with longer treatment durations necessary validate or refute therapeutic efficacy

Language: Английский

Citations

0
Recent Advances in Resveratrol Derivatives: Structural Modifications and Biological Activities DOI Creative Commons
Xiaohan Liu, Yong Pei, Jiahui Li

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 958 - 958

Published: Feb. 19, 2025

Resveratrol, a naturally occurring phenolic stilbene molecule, has been intensively researched for its anti-inflammatory, anticancer, antioxidant, antibacterial, and neuroprotective properties. However, due to limited absorption probable hepatotoxicity, it is difficult employ directly as medication, limiting therapeutic applicability. Over the last five years, numerous structural changes in resveratrol have widely studied, resulting considerable improvements pharmacological activity drug availability. This work reviews biological activities structure-activity relationships (SARs) of derivatives, with goal providing useful insights discovery new derivatives.

Language: Английский

Citations

0
A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy DOI
Qingqi Meng,

Yan Mi,

Libin Xu

et al.

Chinese Journal of Natural Medicines, Journal Year: 2025, Volume and Issue: 23(2), P. 214 - 224

Published: Feb. 1, 2025

Language: Английский

Citations

0
Small-molecule probes based on natural products: Elucidation of drug-target mechanisms in stroke DOI Creative Commons
Xingyue Jin, Suyi Liu,

Shujing Chen

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101290 - 101290

Published: April 1, 2025

Language: Английский

Citations

0
Celery seed derived reconstituted lipid nanoparticles as an innate neuron-targeted neuroprotective nanomedicine for ischemic stroke treatment DOI Creative Commons
Dan Han, Jiaxing Zhang,

Dingran Li

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 17, 2025

Ischemic stroke (IS) is the leading cause of worldwide death while discovery and effective delivery neuroprotective agents for satisfied IS treatment still challenging. In this study, we discover that celery seed (CS) derived reconstituted lipid nanoparticles (CS-rLNPs) can effectively penetrate across blood-brain barrier (BBB) with increased distribution to brain. Especially, CS-rLNPs show innate neuron-targeting ability primarily bind neuron in cerebral ischemic area, which not reported by any parallel studies. Moreover, are found exert therapeutic effects on IS, restore function model mice. Further studies reveal realized through TLR4/MyD88/NF-κB p65 pathway regulated anti-inflammation anti-apoptosis mechanisms. Therefore, serve as a neuron-targeted nanomedicine treatment.

Language: Английский

Citations

0
Integrative microbiomics, proteomics and lipidomics studies unraveled the preventive mechanism of Shouhui Tongbian Capsules on cerebral ischemic stroke injury DOI

Fangjiao Wei,

Jidong Zhou, Lihong Pan

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118874 - 118874

Published: Oct. 1, 2024

Language: Английский

Citations

1
Ethanol extracts of Cinnamomum migao H.W. Li attenuates neuroinflammation in cerebral ischemia-reperfusion injury via regulating TLR4-PI3K-Akt-NF-κB pathways DOI

Wenze Wu,

Libin Xu,

Danyang Mu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119150 - 119150

Published: Nov. 1, 2024

Language: Английский

Citations

1
Elemene mitigates oxidative stress and neuronal apoptosis induced by cerebral ischemia-reperfusion injury through the regulation of glutathione metabolism DOI
Pu Wu,

Long-Hui Cheng,

Yanlei Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119166 - 119166

Published: Nov. 1, 2024

Language: Английский

Citations

1