Journal of Drug Delivery and Therapeutics,
Journal Year:
2024,
Volume and Issue:
14(12), P. 85 - 91
Published: Dec. 15, 2024
This
study
investigates
the
antiepileptic
potential
of
methanolic
extract
Vitex
negundo
leaves
in
seizure
models
induced
mice
using
lithium-pilocarpine,
maximal
electroshock
(MES),
strychnine,
picrotoxin,
and
pentylenetetrazol.
The
demonstrated
a
protective
effect
against
seizures
by
MES
enhanced
efficacy
standard
anticonvulsant
drugs
chemically-induced
seizures.
results
suggest
that
flavonoids
present
may
exert
their
effects
modulating
GABAergic
pathways
blocking
sodium
(Na⁺)
channels
dose-dependent
manner.
These
findings
highlight
as
promising
therapeutic
candidate
for
epilepsy
treatment.
Keywords:
negundo,
extract,
antiepileptic,
animal
models,
pathway
F1000Research,
Journal Year:
2024,
Volume and Issue:
13, P. 754 - 754
Published: July 5, 2024
Introduction
Mitochondria
are
cell
organelles
that
function
as
the
cell’s
main
power
plant,
producing
ATP,
energy
molecule
in
cells.
play
an
important
role
context
of
neuroprotection,
and
mitochondrial
has
been
implicated
various
neurodegenerative
diseases,
including
Alzheimer’s,
Parkinson’s,
amyotrophic
lateral
sclerosis
(ALS).
Recent
research
field
neuroprotection
focused
on
development
therapies
target
mitochondria.
Natural
ingredients
have
long
used
traditional
medicine
show
potential
neuroprotective
agents.
Methods
In
this
work,
a
literature
review
methodology
is
employed
to
gather
data
from
Scopus
database
using
keywords
natural
agents,
herb*,
neuroprotective,
The
were
analyzed
Biblioshiny
VOSviewer
software
produce
visualizations
bibliometric
maps.
We
conducted
quantitative
qualitative
analyses.
Results
trend
found
documents
by
year,
most
global
cited
document,
relevant
sources,
A
factorial
map
illustrating
leading
contributors
papers,
author,
country
or
territory,
subject
area,
network
visualization,
overlay
visualization
scopus
vosviewer,
density
thematic
map,
evolution,
cluster
analysis,
word
cloud.
Conclusions
Agent
Neurotropik
substance
influences
brain’s
nervous
system
peripheral
system,
enhancing
cognition,
mood,
brain
function.
Derived
herbs,
spices,
herbal
products,
it
advantages
over
other
agents
production,
biogenesis,
neuroprotection.
F1000Research,
Journal Year:
2024,
Volume and Issue:
13, P. 754 - 754
Published: Oct. 23, 2024
Introduction
Mitochondria
are
cell
organelles
that
function
as
the
cell’s
main
power
plant,
producing
ATP,
energy
molecule
in
cells.
play
an
important
role
context
of
neuroprotection,
and
mitochondrial
has
been
implicated
various
neurodegenerative
diseases,
including
Alzheimer’s,
Parkinson’s,
amyotrophic
lateral
sclerosis
(ALS).
Recent
research
field
neuroprotection
focused
on
development
therapies
target
mitochondria.
Natural
ingredients
have
long
used
traditional
medicine
show
potential
neuroprotective
agents.
Methods
In
this
work,
a
literature
review
methodology
is
employed
to
gather
data
from
Scopus
database
using
keywords
natural
agents,
herb*,
neuroprotective,
The
were
analyzed
Biblioshiny
VOSviewer
software
produce
visualizations
bibliometric
maps.
We
conducted
quantitative
qualitative
analyses.
Results
trend
found
documents
by
year,
most
global
cited
document,
relevant
sources,
A
factorial
map
illustrating
leading
contributors
papers,
author,
country
or
territory,
subject
area,
network
visualization,
overlay
visualization
scopus
vosviewer,
density
thematic
map,
evolution,
cluster
analysis,
word
cloud.
Conclusions
Agent
Neurotropik
substance
influences
brain’s
nervous
system
peripheral
system,
enhancing
cognition,
mood,
brain
function.
Derived
herbs,
spices,
herbal
products,
it
advantages
over
other
agents
production,
biogenesis,
neuroprotection.
agents’
compositional
heterogeneity
affects
reproductive
results.
Proper
characterization
standardized
extraction
techniques
crucial
for
establishing
plant
extracts’
chemical
profile.
Dosage
consistency
essential
Long-term
safety
toxicity
should
be
evaluated.
Comparing
medicines
with
synthetic
pharmaceuticals
can
enhance
therapy
efficacy
reduce
drug
resistance.
Further
needed
assess
function.
