Insights into Toxicity: Molecular Mechanisms of Aflatoxin B1 and Ochratoxin A in Spices DOI Creative Commons
María Carpena, Ana Perez-Vazquez, Paula Barciela

et al.

Published: Aug. 9, 2024

The European Rapid Alert System for Food and Feed (RASFF) has shown 1133 notifications spices herbs in the last 10 years (2013–2023). analysis of these indicated that 58.7% (665 alerts) alerts corresponded to chemical hazards. Mycotoxins corresponding aflatoxin B1 (24 ochratoxin A (39 were found 19.4% samples. Due presence biological hazards foodstuffs, comprehensive knowledge their molecular mechanisms action is required as part risk assessment strategy. Aflatoxin (AFB1) a known potent carcinogen been linked liver cancer humans animals. Its toxic effects consist forming DNA adducts, causing mutations, interfering with cellular processes. On other hand, (OTA) be nephrotoxic, hepatotoxic, carcinogenic, immunosuppressive both OTA targets kidneys liver, exerting its similarly AFB1, i.e., through damage, oxidative stress, interference This communication reviews mechanism underlying toxicity AFB1 Europe, focusing on biosynthesis, toxicodynamics, interaction components, resulting biochemical pathways leading adverse health effects. Moreover, it discusses potential strategies mitigating spices, emphasizing importance hazard characterization effective management regulation.

Language: Английский

Occurrence, transfer rule, and dietary risk assessment of aflatoxins in medicinal and edible seeds DOI

Jianxin Lv,

Huiru Zhang, Xuwen Wang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: 63, P. 105830 - 105830

Published: Jan. 1, 2025

Language: Английский

Citations

0
From Traditional to Modern: Nanotechnology-Driven Innovation in Mycotoxin Sensing for Chinese Herbal Medicines DOI
Qi Sun, Daniel Chen,

Xia Ran

et al.

Talanta, Journal Year: 2025, Volume and Issue: 288, P. 127681 - 127681

Published: Feb. 2, 2025

Language: Английский

Citations

0
Simultaneous determination of 202 pesticide residues and 19 mycotoxins in coix seed by QuEChERS coupled with LC-Q-TOF/MS and subsequent assessment of dietary exposure risk DOI

Rui Cheng,

Yujie Xie, Qiaoying Chang

et al.

Food Control, Journal Year: 2025, Volume and Issue: unknown, P. 111301 - 111301

Published: March 1, 2025

Language: Английский

Citations

0
The negative aspects of using medicinal plants: human health risks assessment of mycotoxins and toxic metal contamination DOI

Ali Reisi,

Mehrdad Ataie Kachoie,

Leila Ghodrati

et al.

International Journal of Environmental Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: April 18, 2025

Medicinal plants (MPs) have been valued for their therapeutic properties and are crucial in traditional modern medicine. However, contamination with hazardous substances such as mycotoxins toxic THMs (THMs) poses significant safety concerns. This study quantified the levels of ten commonly used MPs Tehran markets, Iran, assessed carcinogenic non-carcinogenic risks to ensure consumer safety. A total 210 samples were analyzed. THMs, including arsenic (As), mercury (Hg), cadmium (Cd), lead (Pb), detected using atomic absorption spectrometry, while aflatoxins (B1, B2, G1, G2) ochratoxin (OTA) measured high-performance liquid chromatography. Risk assessments Target Hazard Quotient (THQ), Index (HI), Incremental Lifetime Cancer (ILCR), Total Carcinogenic (TCR) methodologies. Results revealed variability contaminant (p < 0.05). While heavy metal concentrations within safe limits, mycotoxin exposure posed children, a THQ exceeding acceptable limit. Mycotoxin remained below thresholds. To mitigate risks, storing dry, low-humidity environments is recommended prevent fungal growth reduce contamination, emphasizing need stricter measures.

Language: Английский

Citations

0
Hyperoside alleviates zearalenone-induced liver injury by regulating mitochondrial calcium overload mediated excessive autophagy DOI
Tianyu Han, Lulu Wang, Yan Jiang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156880 - 156880

Published: May 1, 2025

Language: Английский

Citations

0
Visual, fast and highly sensitive detection of zearalenone by two-color optical sensor based on label-free split aptazyme. DOI

Ten H. Lai,

Sun Qinghong,

Zhihua Lv

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 424, P. 136880 - 136880

Published: Nov. 2, 2024

Language: Английский

Citations

2
Insights into Toxicity: Molecular Mechanisms of Aflatoxin B1 and Ochratoxin A in Spices DOI Creative Commons
María Carpena, Ana Perez-Vazquez, Paula Barciela

et al.

Published: Aug. 9, 2024

The European Rapid Alert System for Food and Feed (RASFF) has shown 1133 notifications spices herbs in the last 10 years (2013–2023). analysis of these indicated that 58.7% (665 alerts) alerts corresponded to chemical hazards. Mycotoxins corresponding aflatoxin B1 (24 ochratoxin A (39 were found 19.4% samples. Due presence biological hazards foodstuffs, comprehensive knowledge their molecular mechanisms action is required as part risk assessment strategy. Aflatoxin (AFB1) a known potent carcinogen been linked liver cancer humans animals. Its toxic effects consist forming DNA adducts, causing mutations, interfering with cellular processes. On other hand, (OTA) be nephrotoxic, hepatotoxic, carcinogenic, immunosuppressive both OTA targets kidneys liver, exerting its similarly AFB1, i.e., through damage, oxidative stress, interference This communication reviews mechanism underlying toxicity AFB1 Europe, focusing on biosynthesis, toxicodynamics, interaction components, resulting biochemical pathways leading adverse health effects. Moreover, it discusses potential strategies mitigating spices, emphasizing importance hazard characterization effective management regulation.

Language: Английский

Citations

0