Necroptosis in obesity: a complex cell death event DOI

Zunhai Liu,

Simeng Wang,

Wentao Wang

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Language: Английский

Naotaifang formula regulates Drp1-induced remodeling of mitochondrial dynamics following cerebral ischemia-reperfusion injury DOI
Ruining She, Heyan Tian,

Feiyue Sun

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

3
Neuronal Injury after Ischemic Stroke: Mechanisms of Crosstalk Involving Necroptosis DOI

X. Y. Zhang,

Hongyu Li, Yaowei Zhao

et al.

Journal of Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 75(1)

Published: Feb. 4, 2025

Language: Английский

Citations

0
Insights on the crosstalk among different cell death mechanisms DOI Creative Commons
Georgette Eskander, Sherihan G. AbdelHamid, Sara A. Wahdan

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 10, 2025

Language: Английский

Citations

0
An emerging role of SNAREs in ischemic stroke: From pre-to post-diseases DOI Creative Commons
Yaxin Liu, Jung Hwa Hong, Guozuo Wang

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116907 - 116907

Published: March 1, 2025

Ischemic stroke is a debilitating condition characterized by high morbidity, disability, recurrence, and mortality rates on global scale, posing significant threat to public health economic stability. Extensive research has thoroughly explored the molecular mechanisms underlying ischemic stroke, elucidating strong association between soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor proteins (SNAREs) pathogenesis of this condition. SNAREs, class highly conserved involved in membrane fusion, play crucial role modulating neuronal information transmission promoting myelin formation central nervous system (CNS). Preventing SNARE complex formation, malfunctions SNARE-dependent exocytosis, altered regulation SNARE-mediated vesicle fusion are linked excitotoxicity, endoplasmic reticulum (ER) stress, programmed cell death (PCD) stroke. However, its remain unclear. This study conducts comprehensive review existing literature proteins, encompassing structure, classification, expression family, as well assembly - disassembly cycle complexes their physiological roles CNS. We examine which SNAREs contribute pathological progression associated risk factors (hypertension, hyperglycemia, dyslipidemia, atherosclerosis). Furthermore, our findings highlight promise viable target for pharmacological interventions treatment

Language: Английский

Citations

0
The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion DOI Creative Commons
Yuxuan He, Jingyi Wang,

Chun-Miao Ying

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Stroke ranks as the second most significant contributor to mortality worldwide and is a major factor in disability. Ischemic strokes account for 71% of all stroke incidences globally. The foremost approach treating ischemic prioritizes quick reperfusion, involving methods such intravenous thrombolysis endovascular thrombectomy. These techniques can reduce disability but necessitate immediate intervention. After cerebral ischemia, inflammation rapidly arises vascular system, producing pro-inflammatory signals that activate immune cells, which turn worsen neuronal injury. Following an overload intracellular iron triggers Fenton reaction, resulting excess free radicals cause lipid peroxidation damage cellular membranes, ultimately leading ferroptosis. relationship between ferroptosis increasingly recognized vital process ischemia-reperfusion (I/R). Inflammatory processes disturb balance encourage (LPO) through neuroglial while also reducing activity antioxidant systems, contributing Furthermore, products generated during ferroptosis, along with damage-associated molecular patterns (DAMPs) released from ruptured cell incite inflammation. Given complex inflammation, investigating their interaction brain I/R crucial understanding disease development creating innovative therapeutic options. Consequently, this article will provide comprehensive introduction mechanisms linking neuroinflammation, well evaluate potential treatment modalities, goal presenting various insights alleviating injury exploring new avenues.

Language: Английский

Citations

3
Heat shock proteins in cerebral ischemia-reperfusion injury: Mechanisms and therapeutic implications DOI

Anliu Zhao,

Guangming Zhang,

Huayuan Wei

et al.

Experimental Neurology, Journal Year: 2025, Volume and Issue: 390, P. 115284 - 115284

Published: May 1, 2025

Language: Английский

Citations

0
Investigating the possible mechanism of Cornus officinalis in the therapy of ischemic stroke by UHPLC-Q-TOF-MS, network pharmacology, molecular docking, and experimental verification DOI
Yan Zhang, Peipei Yuan,

Pan-Ying Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 119072 - 119072

Published: Nov. 8, 2024

Language: Английский

Citations

1
Necroptosis in obesity: a complex cell death event DOI

Zunhai Liu,

Simeng Wang,

Wentao Wang

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Language: Английский

Citations

0