Research Progress of Maillard Reaction and its Application in Processing of Traditional Chinese Medicine

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(11)

Published: Nov. 1, 2024

The Maillard reaction, also known as the ‘non-enzymatic browning reaction’, involves a reaction between reducing sugars and amino compounds, including acids proteins. has been increasingly used in production of traditional Chinese medicine food. This study thoroughly examines mechanism factors that influence it techniques for extracting, separating purifying products (MRPs) food processing. Additionally, article explores physiological functions MRPs, highlighting their antioxidant, hepato-protective, antibacterial, immune-boosting, anti-mutagenic, anti-inflammatory, health-promoting, detoxifying antiviral effects. MRPs have diverse outcomes because various influencing factors; they can contain trace amounts potentially harmful constituents, such acrylamide, 5-hydroxymethylfurfural advanced glycosylation products. includes comparative analysis common methods separation purification concentrated MRPs. These consist ultrafiltration, macroporous resin, gel chromatography, ion exchange chromatography dialysis. Results indicate each method advantages disadvantages, thus careful consideration should be placed on specific applications. Furthermore, future outlook research development its is proposed. Given activities are diverse, thorough qualitative quantitative mechanisms, pharmacologically active ingredients needed. offers valuable insights into advancement industries involved medicinal material effectively utilised healthcare clinical practice, offering innovative ideas scientific technological professionals development.

Language: Английский

Rosmarinic Acid Restores the Ceftiofur Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus by Inhibiting Sortase A

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 30, 2024

Methicillin-resistant Staphylococcus aureus (MRSA), one of the most important zoonotic bacterial pathogens, necessitates innovative antibacterial strategies. Rosmarinic acid (RA) possesses various biological functions, including and anti-inflammatory effects. This study aimed to explore synergistic effects mechanism RA in conjunction with ceftiofur (CF) against MRSA. Results showed that combination CF demonstrated anti-MRSA activity, conferring protective an MRSA bacteremia mouse model. Mechanistic investigations further established interacts sortase A (SrtA) through hydrogen bonds, electrostatic, van der Waals forces at critical sites, leading reversible inhibition SrtA activity. Consequently, this impeded ability invade cells form biofilms. Conclusively, directly inhibits thus enhancing effect CF. These findings provide a theoretical foundation for use as therapeutic strategy infections.

Language: Английский