Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 24, 2024
Neurological
disorders
are
characterized
by
high
mortality
and
disability
rates.
Furthermore,
the
burden
associated
with
resulting
from
neurological
has
been
increasing
at
an
alarming
rate.
Botanical
drugs
their
bioactive
components
have
emerged
as
a
prominent
area
of
research,
offering
promising
avenue
for
developing
novel
alternatives
treating
diseases.
Gastrodin
is
principal
active
component
derived
traditional
Chinese
medicinal
plant
Gastrodia
elata
Blume
(GEB).
Existing
literature
reveals
that
gastrodin
exerts
various
pharmacological
protective
actions
against
disorders.
This
review
aimed
to
collate
on
Web
Science,
PubMed,
Embase
CNKI.
The
pharmacokinetics
gastrodin,
its
therapeutic
role
in
disorders,
main
mechanisms
action
clinical
application
were
addressed.
detailed
overview
drug
delivery
systems
physical
enhancement
methods
was
presented,
invaluable
insights
into
potential
research
extensive
applications
gastrodin.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 31, 2025
Neurological
disorders
pose
significant
global
public
health
challenges,
with
a
rising
prevalence
and
complex
pathophysiological
mechanisms
that
impose
substantial
social
economic
burdens.
Traditional
Chinese
Medicine
(TCM),
its
holistic
approach
multi-target
effects,
has
gained
increasing
attention
in
the
treatment
of
neurological
diseases.
This
review
explores
bioactive
compounds
derived
from
herbal
plants,
focusing
on
their
action,
underlying
pathways,
potential
applications
functional
food
development.
The
highlights
neuroprotective
properties
flavonoids,
alkaloids,
polysaccharides,
polyphenols
found
key
TCM
herbs
such
as
Scutellaria
baicalensis
,
Salvia
miltiorrhiza
Ligusticum
chuanxiong
Gastrodia
elata
.
These
have
demonstrated
anti-inflammatory,
antioxidant,
neurogenic
making
them
promising
candidates
for
prevention
conditions,
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
depression.
Furthermore,
synergistic
effects
formulations
targeting
multiple
signaling
pathways
offer
advantages
over
single-target
therapies,
especially
combating
neurodegenerative
also
discusses
challenges
future
directions
integrating
these
into
foods
dietary
supplements,
aiming
to
improve
enhance
clinical
outcomes.
Ultimately,
this
work
aims
provide
valuable
insights
TCM-based
interventions
promoting
well-being
addressing
burden
disorders.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(11), P. 5107 - 5133
Published: Aug. 15, 2024
Abstract
Central
nervous
system
(CNS)‐related
diseases
have
a
high
mortality
rate,
are
serious
threat
to
physical
and
mental
health,
always
been
an
important
area
of
research.
Gastrodin,
the
main
active
metabolite
Gastrodia
elata
Blume,
used
in
Chinese
medicine
food,
has
wide
range
pharmacological
effects,
mostly
related
CNS
disorders.
This
review
aims
systematically
summarize
discuss
effects
underlying
mechanisms
gastrodin
treatment
diseases,
assess
its
potential
for
further
development
as
lead
drug
both
biomedicine
traditional
medicine.
Studies
on
indicate
that
it
may
exert
anti‐neurodegenerative,
cerebrovascular
protective,
ameliorative
diabetic
encephalopathy,
perioperative
neurocognitive
dysfunction,
epilepsy,
Tourette's
syndrome,
depression
anxiety,
sleep
disorders
through
various
mechanisms.
To
date,
110
products
approved
clinical
use,
but
multicenter
case–control
studies
relatively
scarce.
Preclinical
confirmed
can
be
treat
CNS‐related
However,
concerns
need
addressed
context
likely
non‐specific,
assay
interfering
when
is
studied
using
vitro
silico
approaches,
calling
systematic
assessment
evidence
date.
High‐quality
trials
should
priority
evaluate
therapeutic
safety
efficacy
gastrodin.
Further
experimental
research
appropriate
vivo
models
also
needed,
focusing
neurodegenerative
cerebral
ischemic
hypoxic
brain
damage
caused
by
methamphetamine
or
heavy
metals,
epilepsy.
Pharmacological Research,
Journal Year:
2025,
Volume and Issue:
212, P. 107578 - 107578
Published: Jan. 5, 2025
Ginseng
has
been
commonly
used
as
a
traditional
Chinese
medicine
in
Asian
countries
for
thousands
of
years.
Ginsenosides
are
the
main
pharmacologically
active
ingredients
isolated
from
ginseng
and
have
neuroprotective
effects
treatment
neurodegenerative
disorders,
such
Parkinson's
disease
(PD)
Alzheimer's
(AD).
To
summarise
investigate
protective
roles
ginsenosides
their
underlying
mechanisms
PD
AD,
we
''Ginsenoside",
''Parkinson's
disease",
''Alzheimer's
''anti-inflammatory",
''antioxidant",
''apoptosis"
keywords
to
search
extract
relevant
literature
information
scientific
databases
Elsevier,
PubMed,
Google
Scholar
databases.
In
particular,
network
pharmacology
identify
potential
targets
Rg1
Rb1
AD.
By
analysing
existing
research
advances
results,
found
that
ginsenosides,
primarily
mediated
through
anti-inflammation,
anti-apoptosis
anti-oxidative
stress,
etc,
may
be
associated
with
PI3K/Akt,
BDNF/TrkB,
MAPKs,
NF-κB,
Nrf2
Wnt/β-catenin
signalling
pathways.
This
review
systematically
summarises
different
Rg1,
Rb1,
rare
AD
provides
new
strategies
disorders.
Network
paradigm
using
Rb1.
Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
ABSTRACT
Background
and
aim:
Gastrodin,
an
active
compound
derived
from
the
traditional
Chinese
herbal
medicine
Gastrodia,
demonstrates
a
variety
of
pharmacological
effects,
particularly
in
enhancement
neural
functions.
Thus,
aim
this
study
is
to
explore
therapeutic
effects
gastrodin
on
Alzheimer's
disease
(AD)
its
underlying
molecular
mechanisms.
Experimental
procedure:
Cognitive
function
was
assessed
via
Morris
water
maze
Y‐maze
tests.
Tau
pathology,
neuroinflammation,
BBB
dysfunction
were
analyzed
using
various
techniques,
including
Western
blot,
immunohistochemistry,
ELISA.
ADRA1
overexpression
induced
by
lentiviral
infection,
gastrodin's
impact
NF‐κB
p65,
NLRP3,
IL‐1β,
IL‐18
levels
evaluated.
Key
results:
In
vivo
experiment,
enhanced
learning
spatial
memory
3xTg‐AD
mice,
as
well
reducing
p‐Tau
protein
expression
hippocampus
cortex.
Gastrodin
inhibited
ADRA1/NF‐κB/NLRP3
pathway,
which
decreased
glial
cell
activation
inflammatory
cytokines
IL‐1β
IL‐18,
improving
neuron
function.
vitro
NF‐κB/NLRP3
pathway
due
prevented
Aβ
42
‐induced
increase
SH‐SY5Y
cells.
It
also
reduced
cytokine
release,
restoring
tight
junction
bEnd.3
Conclusions
implications:
ameliorates
abilities
alleviating
neuroinflammation
tau
structure
neurons
BBB,
suggesting
that
may
serve
effective
drug
for
treatment
AD.
Acta Pharmacologica Sinica,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Abstract
Demyelination
is
a
common
feature
of
numerous
neurological
disorders
including
multiple
sclerosis
and
leukodystrophies.
Although
myelin
can
be
regenerated
spontaneously
following
injury,
this
process
often
inadequate,
potentially
resulting
in
neurodegeneration
exacerbating
dysfunction.
Several
drugs
aimed
at
promoting
the
differentiation
oligodendrocyte
precursor
cells
(OPCs)
have
yielded
unsatisfactory
clinical
effects.
A
recent
study
has
shifted
strategy
pro-OPC
towards
enhancing
myelinogenesis.
In
we
identified
pro-myelinating
drug
using
zebrafish
model.
Five
traditional
Chinese
medicine
monomers
gastrodin,
paeoniflorin,
puerarin,
salidroside
scutellarin
were
assessed
by
bath-application
Tg
(MBP:eGFP-CAAX)
transgenic
line
1–5
dpf.
Among
5
monomers,
only
gastrodin
exhibited
significant
pro-myelination
activity.
We
showed
that
(10
µM)
enhanced
sheath
formation
(OL)
maturation
without
affecting
number
OLs.
Gastrodin
markedly
increased
phosphorylation
levels
PI3K,
AKT,
mTOR
primary
cultured
OLs
via
direct
interaction
with
PI3K.
Co-treatment
PI3K
inhibitor
LY294002
(5
mitigated
gastrodin-induced
OL
maturation.
Furthermore,
injection
(100
mg·kg
−1
·d
,
i.p.)
effectively
facilitated
remyelination
lysophosphatidylcholine-induced
demyelinating
mouse
model
alleviated
demyelination
experimental
autoimmune
encephalomyelitis
mice.
These
results
identify
as
promising
therapeutic
agent
for
diseases
highlight
potential
screening
pro-myelinogenic
pharmacotherapy.
