Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 24, 2024
Neurological
disorders
are
characterized
by
high
mortality
and
disability
rates.
Furthermore,
the
burden
associated
with
resulting
from
neurological
has
been
increasing
at
an
alarming
rate.
Botanical
drugs
their
bioactive
components
have
emerged
as
a
prominent
area
of
research,
offering
promising
avenue
for
developing
novel
alternatives
treating
diseases.
Gastrodin
is
principal
active
component
derived
traditional
Chinese
medicinal
plant
Gastrodia
elata
Blume
(GEB).
Existing
literature
reveals
that
gastrodin
exerts
various
pharmacological
protective
actions
against
disorders.
This
review
aimed
to
collate
on
Web
Science,
PubMed,
Embase
CNKI.
The
pharmacokinetics
gastrodin,
its
therapeutic
role
in
disorders,
main
mechanisms
action
clinical
application
were
addressed.
detailed
overview
drug
delivery
systems
physical
enhancement
methods
was
presented,
invaluable
insights
into
potential
research
extensive
applications
gastrodin.
The
pathogenesis
of
Alzheimer's
disease
(AD)
remains
incompletely
elucidated,
and
there
is
a
notable
deficiency
in
effective
safe
therapeutic
interventions.
influence
brain
matrix
viscoelasticity
on
the
progression
AD
has
frequently
been
underestimated.
It
imperative
to
elucidate
these
overlooked
pathogenic
factors
innovate
novel
strategies
for
AD.
Gastrodin,
bioactive
constituent
derived
from
traditional
Chinese
medicinal
herb
Gastrodia
elata,
exhibits
range
pharmacological
properties,
notably
enhancement
neural
function.
Nevertheless,
underlying
mechanisms
its
action
remain
insufficiently
elucidated.
Consequently,
this
study
seeks
examine
effects
gastrodin
context
AD,
with
particular
emphasis
potential
viscoelastic
properties
matrix.
This
employs
methodologies,
including
Morris
water
maze
test,
Y-maze
spontaneous
alternation
atomic
force
microscopy
(AFM),
immunofluorescence,
transmission
electron
microscopy,
molecular
docking,
Cellular
Thermal
Shift
Assay
(CETSA),
demonstrate
that
mitigates
tau
pathology
by
modulating
FERMT2,
thereby
reversing
deterioration
mechanical
brain.
Gastrodin
administration
via
gavage
demonstrated
mitigate
cognitive
decline
associated
attenuate
hyperphosphorylation
protein
hippocampus
cortex,
ameliorate
synaptic
damage.
Additionally,
was
observed
counteract
reduction
3xTg-AD
mice,
as
evidenced
upregulation
extracellular
components
pertinent
viscoelasticity,
collagen
types
I
IV.
Furthermore,
docking
CETSA
revealed
strong
binding
affinity
between
FERMT2.
treatment
resulted
FERMT2
fluorescence
intensity,
which
selectively
expressed
astrocytes.
contributed
restoration
blood-brain
barrier
(BBB)
modulated
expression
levels
inflammatory
mediators
interleukin-6
(IL-6),
tumor
necrosis
factor-alpha
(TNF-α),
metallopeptidase
8
(MMP8).
pathology,
enhancing
learning
memory
mouse
models.
effect
may
be
mediated
through
modulation
cerebral
mechanosensor
facilitates
structure
process
potentially
linked
maintenance
BBB
integrity
factor
release.
Journal of Neuroinflammation,
Journal Year:
2025,
Volume and Issue:
22(1)
Published: March 30, 2025
Alzheimer's
disease
(AD)
is
a
complex
neurodegenerative
disorder
characterized
by
significant
neuroinflammatory
responses.
Microglia,
the
immune
cells
of
central
nervous
system,
play
crucial
role
in
pathophysiology
AD.
Recent
studies
have
indicated
that
microglial
efferocytosis
an
important
mechanism
for
clearing
apoptotic
and
cellular
debris,
facilitating
resolution
neuroinflammation.
This
review
summarizes
biological
characteristics
microglia
mechanisms
underlying
efferocytosis,
including
factors
signaling
pathways
regulate
interactions
between
other
influence
this
process,
neuroinflammation
Furthermore,
we
explore
AD
from
three
perspectives:
its
impact
on
clearance
amyloid
plaques,
regulation
neuroinflammation,
effects
neuroprotection.
Finally,
summarize
current
research
status
enhancing
to
alleviate
improve
AD,
as
well
future
challenges
approach
therapeutic
strategy
The American Journal of Chinese Medicine,
Journal Year:
2025,
Volume and Issue:
53(03), P. 803 - 831
Published: Jan. 1, 2025
Gastrodia
elata
Blume,
a
traditional
medicinal
herb
primarily
used
in
Asian
countries
such
as
China,
has
long
been
valued
for
treating
headaches,
dizziness,
spasms,
epilepsy,
strokes,
forgetfulness,
and
other
ailments.
Gastrodin,
glycoside
analog
major
bioactive
component
of
garnered
significant
scientific
attention
owing
to
its
extensive
pharmacological
effects.
It
is
commonly
obtained
through
plant
extraction,
chemical
synthesis,
biosynthesis.
Gastrodin
exhibits
remarkable
modulatory
effects
on
the
central
nervous
system
(CNS),
with
promising
applications
neurodegenerative
diseases
Parkinson’s
disease
(PD)
Alzheimer’s
(AD),
affective
cognitive
disorders.
Furthermore,
pharmacokinetics
(PK)
gastrodin
extensively
reviewed.
As
small
molecule
drug,
this
study
focused
efficiency
molecular
mechanisms
CNS
disorders,
aiming
elucidate
interactions
targets.
This
provides
valuable
insights
development
addresses
drawbacks
unclear
Chinese
medicine.
Current Pharmaceutical Design,
Journal Year:
2024,
Volume and Issue:
30(38), P. 3009 - 3017
Published: Aug. 20, 2024
:
Medicinal
herbs
have
been
utilized
in
the
treatment
of
various
pathologic
conditions,
including
neoplasms,
organ
fibrosis,
and
diabetes
mellitus.
However,
precise
pharmacological
actions
plant
miRNAs
animals
remain
to
be
fully
elucidated,
particularly
terms
their
therapeutic
efficacy
mechanism
action.
In
this
review,
some
important
from
foods
medicinal
are
presented.
Plant
exhibit
a
range
properties,
such
as
anti-cancer,
anti-fibrosis,
anti-viral,
anti-inflammatory
effects,
neuromodulation,
among
others.
These
results
not
only
demonstrated
cross-species
regulatory
effect,
but
also
suggested
that
bioactive
components.
This
shows
promising
prospect
for
used
drugs.
Here,
properties
underlying
mechanisms
highlighted,
which
can
provide
new
insights
clarifying
suggest
way
developing
