Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 24, 2024
Neurological
disorders
are
characterized
by
high
mortality
and
disability
rates.
Furthermore,
the
burden
associated
with
resulting
from
neurological
has
been
increasing
at
an
alarming
rate.
Botanical
drugs
their
bioactive
components
have
emerged
as
a
prominent
area
of
research,
offering
promising
avenue
for
developing
novel
alternatives
treating
diseases.
Gastrodin
is
principal
active
component
derived
traditional
Chinese
medicinal
plant
Gastrodia
elata
Blume
(GEB).
Existing
literature
reveals
that
gastrodin
exerts
various
pharmacological
protective
actions
against
disorders.
This
review
aimed
to
collate
on
Web
Science,
PubMed,
Embase
CNKI.
The
pharmacokinetics
gastrodin,
its
therapeutic
role
in
disorders,
main
mechanisms
action
clinical
application
were
addressed.
detailed
overview
drug
delivery
systems
physical
enhancement
methods
was
presented,
invaluable
insights
into
potential
research
extensive
applications
gastrodin.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12005 - 12005
Published: Nov. 8, 2024
Understanding
the
regulatory
mechanisms
of
adipogenesis
is
essential
for
preventing
obesity.
Interleukin-33
(IL-33)
has
recently
attracted
increasing
attention
its
role
in
adipogenesis.
The
purpose
this
study
was
to
explore
function
and
mechanism
IL-33
receptor
suppression
tumorigenicity
2
(ST2)
on
Here,
Oil
Red
O
staining
used
detect
accumulation
intracellular
lipid
droplets.
Molecular
techniques
such
as
qRT-PCR
Western
blotting
were
expression
pivotal
genes
adipogenic
marker
genes.
Gains
losses
experiments
potential
IL-33/ST2
axis
Functionally,
negatively
associated
with
3T3-L1
preadipocytes,
while
ST2
positively
it,
encompassing
both
trans-membrane
(ST2L)
soluble
(sST2).
Mechanistically,
affects
by
regulating
TRAF6/RelA
pathway
preadipocytes.
Downregulating
suppressed
activation
axis,
which
subsequently
inhibits
TRAF6.
This
further
attenuates
RelA,
ultimately
resulting
reveals
a
new
regulates
differentiation
preadipocytes
provides
idea
improving
obesity
prevention.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 24, 2024
Neurological
disorders
are
characterized
by
high
mortality
and
disability
rates.
Furthermore,
the
burden
associated
with
resulting
from
neurological
has
been
increasing
at
an
alarming
rate.
Botanical
drugs
their
bioactive
components
have
emerged
as
a
prominent
area
of
research,
offering
promising
avenue
for
developing
novel
alternatives
treating
diseases.
Gastrodin
is
principal
active
component
derived
traditional
Chinese
medicinal
plant
Gastrodia
elata
Blume
(GEB).
Existing
literature
reveals
that
gastrodin
exerts
various
pharmacological
protective
actions
against
disorders.
This
review
aimed
to
collate
on
Web
Science,
PubMed,
Embase
CNKI.
The
pharmacokinetics
gastrodin,
its
therapeutic
role
in
disorders,
main
mechanisms
action
clinical
application
were
addressed.
detailed
overview
drug
delivery
systems
physical
enhancement
methods
was
presented,
invaluable
insights
into
potential
research
extensive
applications
gastrodin.
