Integrating metabolomics with network pharmacology to reveal the mechanism of Poria cocos in hyperuricemia treatment DOI
Yiru Wang, Zhijie Yu, Zihao Zhang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118977 - 118977

Published: Oct. 1, 2024

Language: Английский

Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways DOI

Rongrui Zhang,

Yu Xiong,

Yujin Ma

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106679 - 106679

Published: Jan. 18, 2025

Language: Английский

Citations

1
Sequential green extraction, identification, and encapsulation of bioactive compound from Phellinus linteus fruiting body DOI Creative Commons
Tita Foophow, Sittiruk Roytrakul, Vilai Rungsardthong

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102112 - 102112

Published: Feb. 1, 2025

Language: Английский

Citations

1
Identification and mechanistic exploration of key anti‐inflammatory molecules in American ginseng: Impacts on signal transducer and activator of transcription 3 STAT3 phosphorylation and macrophage polarization DOI
Taiping Li,

Yougang Zhang,

Rong Dong

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 4307 - 4320

Published: July 8, 2024

Abstract American ginseng (AG) has been reported to have anti‐inflammatory effects in many diseases, but the key molecules and mechanisms are unclear. This study aims evaluate mechanism of AG identify by vivo vitro models. Zebrafish was employed assess properties compounds. Metabolomics utilized potential AG, while molecular dynamics simulations were conducted forecast interaction capabilities these compounds with inflammatory targets. Additionally, macrophage cell investigate enzyme‐linked immunosorbent assay western blotting. Seven discovered ginsenoside Rg1, Rs3 (G‐Rs3), oleanolic acid exhibiting strongest affinity for signal transducer activator transcription 3. These demonstrated inhibitory on migration zebrafish models ability regulate ROS levels both macrophages. The experiments found that Rs3, could promote M2/M1 polarization ratio inhibit phosphorylation overexpression revealed provided new evidence scientific use AG.

Language: Английский

Citations

7
Anti-melanogenesis activity and chemical profiling of herbaceous peony (Paeonia lactiflora Pall.) flowers: A natural skin whitening agents containing Paeonia monoterpene glycosides DOI Creative Commons
Yixuan Wang,

Zhangtie Wang,

Siyu Chen

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 225, P. 120363 - 120363

Published: Jan. 10, 2025

Language: Английский

Citations

0
Combined network pharmacology and biological verification to investigate anti-influenza A virus effect and potential mechanism of Pudilan Xiaoyan Oral Liquid DOI Open Access
Hualing Li, Wenlei Wang,

Zhihui Zheng

et al.

Chinese Herbal Medicines, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Integrated physiological, microbial, and metabolomics analyses revealed the differences in different varieties of Paeonia lactiflora Pall DOI Creative Commons
Shuang Wu, Beijing Tian, Chenggang Shan

et al.

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 16

Published: May 23, 2025

Paeonia lactiflora Pall ( P. ) is a perennial herb with high medicinal and economic value. In the growth process of , plant’s root secondary metabolism intricately linked to microbial communities that surround it. However, few systematic studies have reported changes in microbiome metabolites during cultivation thus far. this study, amplicon sequencing technology was used determine difference rhizosphere microorganisms . The non-targeted metabolomics method metabolites, relationship between demonstrated by co-expression network analysis. paeoniflorin content (PC) determined HPLC. total phenol (TPC) Folin–Ciocalteu method, flavonoid (TFC) NaNO 2 -Al (NO 3 method. antioxidants were evaluated DPPH, ABTS, FRAP methods. Results showed Proteobacteria had highest relative abundance among all phyla, Halomonas genera. results 693 207 differential detected four groups, which mainly enriched biosynthesis phenylpropanoids, phenylpropanoid biosynthesis, taste transduction, central carbon cancer, plant metabolites. also PC, TPC, TFC, antioxidant capacity white group higher than those other groups. This study revealed differences different varieties provided theoretical support for breeding data reference improving quality regulating species.

Language: Английский

Citations

0
Mechanistic insights into xanthomicrol as the active anti-HCC ingredient of Phytolacca acinosa Roxb.: a network pharmacology analysis and transcriptomics integrated experimental verification DOI

Jiayao Liu,

Yang Zhou,

Pincheng Zhou

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118467 - 118467

Published: Oct. 1, 2024

Language: Английский

Citations

3
Traditionally Used Edible Flowers as a Source of Neuroactive, Antioxidant, and Anti-Inflammatory Extracts and Bioactive Compounds: A Narrative Review DOI Creative Commons

Maciej Książkiewicz,

Michalina Karczewska,

Filip Nawrot

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 677 - 677

Published: Feb. 4, 2025

Edible flowers are becoming a popular addition to diets. As science has progressed, it been proven that in their aesthetic value, they possess pharmacological effects and health-promoting properties. Several edible used medicine, the available literature data indicate broad biological activity. This review focuses on knowledge about neuroactive, antioxidant, anti-inflammatory potential of 15 traditionally flowers. It also describes uses summarizes research findings chemical composition.

Language: Английский

Citations

0
Optimization of fermentation conditions for peptides from waste jasmine flower and its anti-aging effect on H2O2-induced normal human dermal fibroblasts DOI
Mengqi Wu,

Xinxin Wei,

Hongyu Feng

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 218, P. 118880 - 118880

Published: June 8, 2024

Language: Английский

Citations

2
Phytochemical analysis, antimicrobial and antioxidant activities of essential oils of the species Artemisia mesatlantica maire: in vitro and in silico approaches DOI Creative Commons
Khalid Chebbac, Oussama Abchır, Mohammed Chalkha

et al.

CyTA - Journal of Food, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 19, 2024

In the present work, we assessed antioxidant, antibacterial, and antifungal activities of chemically defined Artemisia mesatlantica Maire (EOAM) essential oils. The GC-MS analysis EOAM showed presence active promising compounds. important antioxidant capacity through DPPH, FRAP TAC assays. in vitro antimicrobial screening that had antibacterial activity, with inhibition zones ranging from 20.67 to 38.35 mm on solid media inhibitory doses 2.34 4.78 µg/mL liquid media. It also exhibits activities, diameters 15.67 61.57 at 2.90 12.54 µg/mL. was resistant Aspergillus flavus (A. flavus). addition, molecular docking, dynamics simulations, ADMET analyses validated activities. This research suggests A. may fight drug-resistant bacteria. These results demonstrate potential produce novel solutions.

Language: Английский

Citations

2