Dual role of Nrf2 signaling in hepatocellular carcinoma: promoting development, immune evasion, and therapeutic challenges

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 2, 2024

Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and ranks as third leading cause cancer-related mortality globally. The performs a wide range tasks primary organ responsible for metabolizing harmful substances foreign compounds. Oxidative stress has crucial role in growth improvement hepatocellular (HCC). Nuclear factor erythroid 2 ( 1 )-related (Nrf2) an element that regulates transcription located cytoplasm. It controls balance redox reactions by stimulating expression many genes depend on antioxidant response elements. Nrf2 contrasting functions normal, healthy HCC. In normal liver, provides advantageous benefits, while HCC it promotes effects support survival Continuous activation been detected its advancement aggressiveness. addition, Activation may lead to immune evasion, weakening cells’ ability attack tumors thereby promoting tumor development. Furthermore, chemoresistance HCC, which considered chemotherapy medications, significantly impedes effectiveness treatment. Stress management typically accomplished activating specific signal pathways chemical variables. One important creation nuclear factor-E2-related (Nrf2). production group encode proteins protecting cells from damage. This occurs through Nrf2/ARE pathway, mechanism combating oxidative within cells.

Language: Английский

Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(10), P. 8129 - 8143

Published: May 25, 2024

Language: Английский

Effect of Agkistrodon acutus venom (AAVC-I) on apoptosis through modulation of the Keap1/Nrf2 pathway in HSC-3 oral squamous cell carcinoma cells

Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(8), P. 4341 - 4353

Published: Aug. 1, 2024

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in oral and maxillofacial regions. Patients with OSCC exhibit a poor response to conventional chemoradiotherapies, which are associated severe side effects. Therefore, it essential identify an effective therapeutic method treat patients OSCC. An anti-tumor compound,

Language: Английский