Ling-Gui-Zhu-Gan decoction inhibits cardiomyocyte pyroptosis via the NLRP3/Caspase-1 signaling pathway DOI

Xiao-ni Zhao,

Huimin Ding,

Yao-yao Ma

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102588 - 102588

Published: Oct. 20, 2024

Language: Английский

Stir-frying duration modulates structural characterization and functional properties of Atractylodes macrocephala polysaccharides DOI
Wei Li, Xiaoxiao Wang, Xiuyan Sun

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141489 - 141489

Published: Feb. 27, 2025

Language: Английский

Citations

1
Atractylenolide-I prevents abdominal aortic aneurysm formation through inhibiting inflammation DOI Creative Commons
Shuxiao Chen, Xiaotian Liu,

Xincheng Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 31, 2025

Abdominal aortic aneurysm (AAA) is a degenerative disease with high mortality. Chronic inflammation plays vital role in the formation of AAA. Atractylenolide-I (ATL-I) major bioactive component Rhizoma Atractylodis Macrocephalae that exerts anti-inflammatory effects various diseases. The purpose this study to investigate ATL-I progression AAA was constructed C57BL/6 mice by porcine pancreatic elastase (PPE)-incubation, and diameter aorta measured ultrasound. administered gavage on second day after modeling explore its significance pathological molecular alteration investigated immunostaining, ELISA, qRT-PCR Western blotting. inhibited dilatation abdominal decreased incidence alleviated infiltration macrophages adventitia reduced levels proinflammatory factor IL-1β IL-6 circulatory system, while increasing expression IL-10. Moreover, restrained loss smooth muscle cells elastic fiber degradation suppressing MMP-2 MMP-9 expression. Mechanistically, phospho-AMPK elevated groups, administration suppressed improve damage aorta. meliorated vascular targeting AMPK signaling, ultimately inhibiting formation, which provided an alternative agent for treatment.

Language: Английский

Citations

0
Melanoidins from stir-frying Atractylodes Macrocephala: Structural characterization, molecular weight distribution, and polyphenol delivery mechanism DOI
Wei Li, Yajie Zhang, Xiaoxiao Wang

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144238 - 144238

Published: April 1, 2025

Language: Английский

Citations

0
Gut Microbiota and Their Metabolites as Modulators of Vascular Complications in Diabetes DOI Creative Commons

Meng Yun Duan,

Jielu Wen,

Anning Chen

et al.

Published: Jan. 7, 2025

Review Gut Microbiota and Their Metabolites as Modulators of Vascular Complications in Diabetes Meng Duan 1,2,3,†, Jielu Wen 1,2,†, Anning Chen 1,2,† Sifan 1,2,* 1 Guangdong Provincial Key Laboratory Malignant Tumor Epigenetics Gene Regulation, Guangdong-Hong Kong Joint for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, University, Guangzhou 510000, China 2 Nanhai Translational Innovation Center Precision Immunology, Foshan 528200, 3 Zhongshan School Yat-sen * Correspondence: [email protected] † These authors contributed equally to this work. Received: 8 November 2024; Revised: 29 Accepted: 24 December Published: 7 January 2025 Abstract: With the global rise population aging, along with increasing burden overweight obesity, prevalence diabetes is expected surge dramatically. Microvascular macrovascular complications are leading causes death among patients type diabetes. Recent advancements have provided evidence suggesting that gut microbiota directly or indirectly regulate vascular function. This review focuses on complex interactions between its metabolites In particular, we highlight novel therapeutic effects interventions such probiotics, dietary modifications, fecal transplantation improving composition reducing risk findings not only provide new insights into pathological mechanisms diabetic but also reveal ideas guiding formulation future treatment strategies.

Language: Английский

Citations

0
Mitochondrial function: A new direction for the targeted treatment of cardiovascular diseases with Chinese herbal medicine DOI Creative Commons
Lin Yang, Liang Wang, Baofeng Yang

et al.

Journal of Holistic Integrative Pharmacy, Journal Year: 2025, Volume and Issue: 6(1), P. 91 - 104

Published: March 1, 2025

Language: Английский

Citations

0
SIRT1‐Mediated Regulation of STAT3/SOCS3 Inhibits Insulin Resistance in Trophoblast Cells and Improves Gestational Diabetes Mellitus DOI
Ya Wen, Jue Wang,

Mengjia Duan

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(9)

Published: May 10, 2025

ABSTRACT Gestational diabetes mellitus (GDM) frequently arises during pregnancy and is closely linked to insulin resistance (IR). The objective of this study was explore the role SIRT1 possible processes involved in IR GDM trophoblast cells. An cell model induced by glucosamine a mouse high‐fat high‐sugar feeding were constructed. Cell viability determined CCK‐8 assay, presence associated proteins identified through western blotting, immunohistochemistry, immunofluorescence techniques. Measurements body mass, fasting blood concentrationsglucose levels, insulin, oral glucose tolerance (OGTT) obtained, placental tissues examined using HE PAS staining. findings revealed reduced expression patients, animals, models. overexpression can significantly increase uptake capacity IR‐treated cells; p‐IRS1, p‐AKT, GLUT4; decrease GLUT1. Furthermore, diminished SOCS3 hindering phosphorylation acetylation STAT3, thereby improving IR. In model, improved Overall,SIRT1 reduces cells suppression STAT3–SOCS3 signaling pathway, providing new idea for clinical intervention GDM.

Language: Английский

Citations

0
Ling-Gui-Zhu-Gan decoction inhibits cardiomyocyte pyroptosis via the NLRP3/Caspase-1 signaling pathway DOI

Xiao-ni Zhao,

Huimin Ding,

Yao-yao Ma

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102588 - 102588

Published: Oct. 20, 2024

Language: Английский

Citations

0