Integrating Metabolomics and Network Analyses to Explore Mechanisms of Geum japonicum var. chinense Against Pulmonary Fibrosis: Involvement of Arachidonic Acid Metabolic Pathway

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1462 - 1462

Published: Feb. 10, 2025

Pulmonary fibrosis (PF) emerges as a significant pulmonary sequelae in the convalescent phase of coronavirus disease 2019 (COVID-19), with current strategies neither specifically preventive nor therapeutic. Geum japonicum var. chinense (GJC) is used traditional Chinese medicine to effectively treat various respiratory conditions. However, protective effects GJC against PF remains unclear. In present study, anti-PF effect aqueous extract was studied using mouse model induced by bleomycin (BLM). To characterize metabolite changes related and reveal therapeutic targets for extract, we performed metabolomic network analysis on mice lungs. Finally, key were then validated Western blotting. alleviated onset progression lung inhibiting inflammatory responses regulating oxidative stress levels. Integrating serum metabolomics analyses showed arachidonic acid (AA) pathway be most important metabolic PF. Further validation AA protein levels rise ALOX5, PTGS2, CYP2C9, PLA2G2A treatment regulated above programming. conclusion, promising botanical drug delay mice. The primary mechanism action associated comprehensive regulation metabolites expression pathway.

Language: Английский

Health benefits of medicinal plant natural products via microbiota-mediated different gut axes

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107730 - 107730

Published: April 1, 2025

This review examines the multifaceted roles of medicinal plant natural products in influencing gut microbiota and their subsequent impact on various organ systems through established axes, including gut-brain, gut-liver, gut-heart, gut-lung, gut-kidney axes. Medicinal have exhibited diverse pharmacological activities, modulation composition, enhancement metabolic processes, alleviation inflammation oxidative stress. Evidence suggests that these components can ameliorate conditions such as neurological disorders, syndrome, chronic kidney disease by restoring microbial balance improving barrier integrity. Furthermore, highlights potential to foster beneficial communities improve health, which may lead reduced severity inflammation. By comprehensively analyzing current literature, this provides a foundation for future research aim at exploring therapeutic applications prevention treatment. The findings underscore need further studies elucidate underlying mechanisms action validate clinical efficacy managing modulation.

Language: Английский