Synergistic antimicrobial efficacy of glabrol and colistin through micelle-based co-delivery against multidrug-resistant bacterial pathogens
Ying Liu,
No information about this author
Mengying Zhang,
No information about this author
Yawei Cai
No information about this author
et al.
Phytomedicine,
Journal Year:
2025,
Volume and Issue:
137, P. 156371 - 156371
Published: Jan. 5, 2025
Language: Английский
Glabridin restore the sensitivity of colistin against mcr-1-positive Escherichia coli by polypharmacology mechanism
Qianwei Qu,
No information about this author
Mengmeng Zhao,
No information about this author
Haixin Peng
No information about this author
et al.
Microbiological Research,
Journal Year:
2025,
Volume and Issue:
293, P. 128070 - 128070
Published: Jan. 18, 2025
Language: Английский
Repurposing fenticonazole nitrate to restore colistin susceptibility in multidrug-resistant bacteria
Yueyue Ji,
No information about this author
Chenchen Wang,
No information about this author
Hongjiang Lai
No information about this author
et al.
Life Sciences,
Journal Year:
2025,
Volume and Issue:
unknown, P. 123511 - 123511
Published: March 1, 2025
Language: Английский
Fusion of Morpholine and Schiff Base on Novel Benzimidazole Scaffold as Anti-Microbial Agents: A Computational Approach and In-vitro Evaluation
The Open Medicinal Chemistry Journal,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: April 9, 2025
Background
Benzimidazole
is
a
well-known
bioactive
heterocyclic
compound
with
diverse
pharmacological
properties.
In
this
study,
the
fusion
of
morpholine
and
Schiff
base
motifs
benzimidazole
has
been
explored
to
enhance
their
antimicrobial
activity
against
bacterial
fungal
pathogens.
Computational
methods
complement
experimental
findings
by
providing
insights
into
binding
interactions
drug-likeness
Aims
Objective
The
study
aimed
synthesizenovelbenzimidazole
derivatives
fused
basesand
evaluate
efficacy
properties
through
assays
computational
modeling.
Methods
titled
compounds
were
synthesized
following
multi-step
chemical
process
characterized
using
various
spectroscopic
techniques.
was
assessed
strains
in-vitro
assays.
docking
performed
affinities
target
enzymes,
also
pharmacokinetic
physicochemical
analyzed
determine
Results
Synthesized
demonstrated
significant
activity,
particularly
3b
3e
,
which
showed
potent
inhibition
studies
confirmed
favorable
profiles,
correlating
well
findings.
Conclusion
highlights
potential
bases
as
promising
agents.
These
pave
way
for
further
exploration
therapeutic
applications,
in
combating
resistance.
Language: Английский
Effect of emodin on Streptococcus suis by targeting β-ketoacyl-acyl carrier protein synthase Ⅱ
Phytomedicine,
Journal Year:
2025,
Volume and Issue:
143, P. 156821 - 156821
Published: May 1, 2025
Language: Английский
Phytoestrogens: Pharmacological Potential and Therapeutic Insights for Urinary Tract Infections
Ming‐Liang He,
No information about this author
Yisheng Yin,
No information about this author
Gan Yu
No information about this author
et al.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 30, 2024
Urinary
tract
infections
(UTIs)
are
exceptionally
common
in
postmenopausal
female
or
patients
with
diabetes
mellitus
nephrolithiasis,
carrying
substantial
burden
on
and
healthcare
system.
Increasing
proportion
ongoing
spread
of
antibiotic-resistant
pathogens
have
further
debilitated
the
condition
battlefield
against
UTIs.
Lack
estrogen
may
contribute
to
high
inclination
UTIs
after
menopause
hormone
replacement
therapy
can
mitigate
symptoms
hot
flashes,
vaginal
dryness
UTIs,
rationalizing
usage
analogues
treatment
prophylaxis
Phytoestrogens
which
comprise
flavonoids,
coumerins,
stilbenes,
lignans,
natural
botanical
compounds
structural
similarity
biochemical
features.
emerged
as
adjuvant
remedy
for
uropathogenic
bacteria
even
multidrug-resistant
ones,
multifaceted
mechanisms
such
inhibition
adhesion
invading
ability
bacteria,
destruction
biofilms,
synergistically
enhancement
antibiotics
activity.
It
is
plausible
propose
phytoestrogens
potential
agents
combination
other
strategies
ameliorate
challenge
multi-drug
resistance
Language: Английский
Enzymatic oxidation increases the antibacterial activity of myricetin against Staphylococcus aureus
Jiao Li,
No information about this author
Min Sun,
No information about this author
Yu Pan
No information about this author
et al.
Food Chemistry,
Journal Year:
2024,
Volume and Issue:
463, P. 141250 - 141250
Published: Sept. 16, 2024
Language: Английский
Encapsulation nanoarchitectonics of glabridin with sophorolipid micelles for addressing biofilm hazards via extracellular polymeric substance permeation and srtA gene suppression
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
286, P. 117150 - 117150
Published: Oct. 17, 2024
Language: Английский