Eight new triterpenoid saponins from the leaves of Astragalus membranaceus (Fisch.) Bunge and their neuroprotective effects DOI

Wen-xiang Xu,

Zhen-yun Liu,

Qing‐Zhou Bu

et al.

Fitoterapia, Journal Year: 2025, Volume and Issue: 183, P. 106559 - 106559

Published: April 19, 2025

Language: Английский

New triterpenoid saponins isolated from the leaves of Astragalus membranaceus (Fisch.) Bge. and their neuroprotective effects DOI
Wenxiang Xu, Xinyuan Li, Qian Zhang

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108149 - 108149

Published: Jan. 9, 2025

Language: Английский

Citations

2
The Gut Microbiota‐Xanthurenic Acid‐Aromatic Hydrocarbon Receptor Axis Mediates the Anticolitic Effects of Trilobatin DOI Creative Commons
Xiaoyu Wu,

Jiajia Wei,

Ran Wang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Current treatments for ulcerative colitis (UC) remain limited, highlighting the need novel therapeutic strategies. Trilobatin (TLB), a naturally derived food additive, exhibits potential anti‐inflammatory properties. In this study, dextran sulfate sodium (DSS)‐induced animal model is used to investigate effects of TLB on UC. It found significantly alleviates DSS‐induced UC in mice, as evidenced by reduction disease activity index, an increase colon length, improvement histopathological lesions. Furthermore, treatment results decrease proinflammatory cytokines and cytokines. mitigates modulating intestinal microbiota, particularly Akkermansia , which enhances tryptophan metabolism upregulates production xanthurenic acid (XANA). To confirm role TLB‐induced microbiota changes, experiments are performed with pseudogerm‐free mice fecal transplantation. also identified XANA key metabolite that mediates TLB's protective effects. Both markedly activate aromatic hydrocarbon receptor (AhR). Administration AhR antagonist abrogates their effects, thereby confirming involvement underlying mechanism. conclusion, study reveals mechanism through correcting imbalances, regulating metabolism, enhancing production, activating AhR.

Language: Английский

Citations

1
The gut microbiome and the brain DOI
N. A. Rykalo, Lydia Riehl, Michaela Kress

et al.

Current Opinion in Supportive and Palliative Care, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Purpose of review The importance the gut microbiome for human health and well-being is generally accepted, elucidating signaling pathways between host offers novel mechanistic insight into (patho)physiology multifaceted aspects healthy aging brain functions. Recent findings tightly linked with nervous system, microbiota are increasingly emerging as important regulators emotional cognitive performance. They send receive signals bidirectional communication via immunological, neuroanatomical, humoral pathways. composition spectrum metabolites neurotransmitters that they release changes increasing age, nutrition, hypoxia, other pathological conditions. Changes in (dysbiosis) associated critical illnesses such cancer, cardiovascular, chronic kidney disease but also neurological, mental, pain disorders, well chemotherapies antibiotics affecting development function. Summary Dysbiosis a concomitant imbalance mediators both causes consequences diseases brain. Understanding microbiota’s role pathogenesis these disorders will have major clinical implications offer new opportunities therapeutic interventions.

Language: Английский

Citations

4
Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity DOI Open Access
Jiajia Wei,

Gongchun Lan,

Wenfang Zhang

et al.

British Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Background and Purpose Doxorubicin (DOX), an anthracycline chemotherapeutic agent, whose use is limited owing to its dose‐dependent cardiotoxicity. Mitochondrial oxidative stress plays a crucial role in the pathogenesis of DOX‐induced cardiotoxicity (DIC). Trilobatin (TLB), naturally occurring food additive, exhibits strong antioxidant properties, but cardioprotective effects DIC unclear. This study investigates effect TLB on DIC. Experimental Approach DOX was used generate vivo vitro model Echocardiography, enzyme‐linked immunosorbent assay (ELISA) haematoxylin eosin (H&E) staining were evaluate cardiac function these models. To identify targets TLB, RNA‐sequence analysis, molecular dynamics simulations, surface plasmon resonance binding assays protein immunoblotting techniques used. Transmission electron microscopy, along with dihydroethidium Mito‐SOX staining, conducted examine impact trilobatin mitochondrial stress. SiRNA transfection performed confirm ferredoxin 1 (FDX1) development. Key Results In mice, improved manner inhibited myocardial fibrosis mice. also attenuated dysfunction reduced found directly bind FDX1 suppresses cuproptosis after treatment, causing significant inhibition cuproptosis‐related proteins. Conclusions Implications first show that strongly inhibits by reducing controlling DOX‐mediated targeting FDX1. Therefore, as potential phytochemical candidate for ameliorating

Language: Английский

Citations

0
Unlocking the neuroprotective secrets of natural products: a focus on the gut-brain axis DOI
Xiliang Yang, Die Hu,

R. Cheng

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

0
Eight new triterpenoid saponins from the leaves of Astragalus membranaceus (Fisch.) Bunge and their neuroprotective effects DOI

Wen-xiang Xu,

Zhen-yun Liu,

Qing‐Zhou Bu

et al.

Fitoterapia, Journal Year: 2025, Volume and Issue: 183, P. 106559 - 106559

Published: April 19, 2025

Language: Английский

Citations

0