Pathophysiological Role of Neutrophil Extracellular Traps in Diet-Induced Obesity and Metabolic Syndrome in Animal Models

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 241 - 241

Published: Jan. 10, 2025

The global pandemic of obesity poses a serious health, social, and economic burden. Patients living with are at an increased risk developing noncommunicable diseases or to die prematurely. Obesity is state chronic low-grade inflammation. Neutrophils first be recruited sites inflammation, where they contribute host defense via phagocytosis, degranulation, extrusion neutrophil extracellular traps (NETs). NETs web-like DNA structures nuclear mitochondrial associated cytosolic antimicrobial proteins. primary function NETosis preventing the dissemination pathogens. However, neutrophils may occasionally misidentify molecules as danger-associated molecular patterns, triggering NET formation. This can lead further recruitment neutrophils, resulting in propagation vicious cycle persistent systemic scenario occur when infiltrate expanded obese adipose tissue. Thus, implicated pathophysiology autoimmune metabolic disorders, including obesity. review explores role two obesity-associated conditions-hypertension liver steatosis. With rising prevalence driving research into its pathophysiology, particularly through diet-induced models rodents, we discuss insights gained from both human animal studies. Additionally, highlight potential offered by rodent opportunities presented genetically modified mouse strains for advancing our understanding obesity-related

Language: Английский

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SLAMF7 is a key molecule that promotes M1 polarization in lung tissue macrophages of high-fat diet-fed asthma mice model

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114203 - 114203

Published: Feb. 3, 2025

Language: Английский

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Exploring the anti-inflammatory effects of Radix Curcumae essential oil in pulmonary sarcoidosis via the TLR4/MyD88/NF-κB pathway

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156496 - 156496

Published: Feb. 11, 2025

Language: Английский

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Single cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 26, 2025

Pediatric obesity-related asthma is characterized by non-atopic T helper 1 (Th1) inflammation and steroid resistance. CDC42 upregulation in CD4 + cells underlies Th1 but the cell subtype(s) with their contribution to resistance are not known. Compared healthy-weight asthma, obesity-alone controls, single-cell transcriptomics of obese revealed 3 clusters comprised naïve central memory cells, which differed from cluster enriched for responses that was effector cells. NR3C1, coding glucocorticoid receptor, downregulated, while genes NLRP3 inflammasome were upregulated, responses. Conserved these correlated pulmonary function deficits asthma. These findings suggest several distinct subtypes programmed upregulation, inflammation, resistance, together contribute phenotype.

Language: Английский

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The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

Phthalates (PAEs) are widely used plasticizers in polyvinyl chloride (PVC) products since the 1930s, and recent research indicates a significant association between exposure to these substances development progression of asthma chronic obstructive pulmonary disease (COPD). Understanding underlying mechanisms is crucial due their public health implications. In this study, we utilized innovative network toxicology molecular docking techniques systematically examine effects seven typical phthalates on COPD. By integrating information from multiple databases, identified key target genes linked compounds conducted functional enrichment analyses elucidate roles pathological processes. Our results demonstrate that affect pathogenesis COPD by modulating various genes, including PTGS2, MMP9, CASP3, which involved essential biological pathways such as apoptosis immune response. Interestingly, certain inflammation-related signaling displayed novel regulatory patterns when exposed phthalates, revealing new mechanisms. Molecular further confirmed stable interactions providing molecular-level insights into pathogenic Overall, study highlights harmful impacts COPD, establishing connections disease-related emphasizing relevance emerging environmental toxins. These findings provide valuable perspectives for risk assessment policy, underscoring need stricter regulations interventions regarding phthalate exposure.

Language: Английский

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HFD-induced LPS translocation and elevated blood lipids exacerbated the inflammatory response in allergic rhinitis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 15, 2025

Allergic rhinitis (AR) is one of the most prevalent chronic diseases, with studies indicating that a high-fat diet (HFD) may heighten susceptibility to AR. This study aims investigate impact HFD on ovalbumin (OVA)-induced AR using both an OVA-sensitized rat model and macrophage treated palmitic acid (PA). The systemic effects were explored respect intestinal barrier integrity, serum lipids lipopolysaccharide (LPS) levels, inflammatory response. In rats fed HFD, there was reduction in expression tight junction proteins colon tissues, increased levels LPS, elevated responses nasal lavage fluid (NLF) serum. Additionally, enhanced NF-κB NLRP3 inflammasome activity observed tissues. vitro experiments demonstrated PA LPS synergistically amplified THP-1-derived macrophages, paralleling findings. These results suggest HFD-induced dysfunction facilitates translocation into bloodstream. Elevated level, together blood exacerbate response through activation inflammasome.

Language: Английский

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Single-cell analysis identifies distinct CD4+ T cells associated with the pathobiology of pediatric obesity-related asthma

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Pediatric obesity-related asthma is characterized by non-atopic T helper 1 (Th1) inflammation and steroid resistance. CDC42 upregulation in CD4+T cells underliesTh1 but the cell subtype(s) with their contribution to resistance are not known. Compared healthy-weight asthma, obesity-alone controls, single-cell transcriptomics of obese revealed

Language: Английский

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