Anticancer Activity Promoted by Ligand Diversity in Diiron Thiocarbyne Complexes

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117364 - 117364

Published: Feb. 5, 2025

Language: Английский

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The IGF2BP2-circ-DAPK1 axis promotes high-glucose-induced ferroptosis of HUVECs by decreasing NQO1 expression

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167797 - 167797

Published: March 1, 2025

Language: Английский

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Natural compounds targeting ferroptosis in ovarian cancer: research progress and application potential

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107729 - 107729

Published: April 1, 2025

Ovarian cancer (OC) is among the most common malignancies in female reproductive system, marked by high rates of recurrence and mortality. Conventional chemotherapy, however, faces limitations due to development drug resistance, which hinders its effectiveness. Ferroptosis, an atypical form programmed cell death distinct from autophagy, apoptosis, necrosis, relationship with tumors has become a hot research area studies recent years. Anticancer therapies that target ferroptosis show strong potential improving prognosis counteracting chemotherapy resistance. Natural compounds, as valuable source novel targeted anticancer agents, significant role inhibiting tumor proliferation metastasis therapeutic sensitivity been demonstrated numerous existing studies. This review summarizes range natural compounds OC cells, discussing their active components, mechanisms action, potential, thereby providing useful insights for future therapy OC.

Language: Английский

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SP600125, a selective JNK inhibitor, is a potent inhibitor of NAD(P)H: quinone oxidoreductase 1 (NQO1)

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Language: Английский

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