Reactive astrocytes in spinal cord injury: An analysis of heterogeneity based on temporality and spatiality, potential therapies, and limitations DOI

Mengting Qian,

Zheng Wang, Hang Liu

et al.

Journal of Neuropathology & Experimental Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Spinal cord injury (SCI) constitutes a profound central nervous system disorder characterized by significant neurological dysfunction and sensory loss below the site. SCI elicits multifaceted cellular response in which proliferation of reactive astrocytes ensuing diversity their functions phenotypes play pivotal roles within microenvironment, especially during secondary phases condition. This review explores activation heterogeneity following SCI. It underscores necessity delineating among astrocyte subpopulations throughout phase Developing therapeutic strategies that capitalize on beneficial properties certain while mitigating adverse effects others could have implications for future clinical management

Language: Английский

Identification of Novel LCN2 Inhibitors Based on Construction of Pharmacophore Models and Screening of Marine Compound Libraries by Fragment Design DOI Creative Commons

Ningying Zheng,

Xuan Li, Nan Zhou

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(1), P. 24 - 24

Published: Jan. 5, 2025

LCN2, a member of the lipocalin family, is associated with various tumors and inflammatory conditions. Despite availability known inhibitors, none have been approved for clinical use. In this study, marine compounds were screened their ability to inhibit LCN2 using pharmacophore models. Six optimized protein binding after being docked against positive control Compound A. Two showed promising results in ADMET screening. Molecular dynamics simulations utilized predict mechanisms, 69081_50 identified as potential inhibitor. MM-PBSA analysis revealed key amino acid residues that are involved interactions, suggesting could be candidate drug development.

Language: Английский

Citations

0
Shrimp peptide QMDDQ improves scopolamine-induced memory impairments by activating the Notch1 signaling pathway DOI

Peng-Fei Yan,

Junchao Wang,

Xiyu Zhao

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106041 - 106041

Published: Feb. 1, 2025

Language: Английский

Citations

0
Mechanism of LCN2 in cerebral ischemia-reperfusion injury DOI Creative Commons

Luo-yang Cai,

Ying Yuan, Hai Huang

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 20, 2025

Cerebral ischemia-reperfusion injury (CIRI) is a complex pathophysiological process faced by brain tissues after ischemic stroke treatment, which involves mechanisms of inflammatory response, oxidative stress and apoptosis, severely affects treatment outcome. Lipocalin-2 (LCN2), an acute-phase protein, significantly up-regulated CIRI promotes neural repair enhancing astrocyte phagocytosis, but its over-activation may also trigger secondary inflammation demyelination injury. LCN2 plays key role in neuroinflammation regulation regulating the polarization state astrocytes release factors, affect integrity blood–brain barrier variety pathologic processes. In view important CIRI, this article reviews mechanism LCN2, aiming to provide new ideas methods for stroke.

Language: Английский

Citations

0
Herkinorin ameliorates neuronal damage in a pentylenetetrazol-induced epilepsy rat model through altering microglial and astrocytic activation by inhibiting PARP1 and NF-κB DOI
Yun Liu,

Wenmei Zhao,

Xia Lv

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114588 - 114588

Published: April 10, 2025

Language: Английский

Citations

0
Reactive astrocytes in spinal cord injury: An analysis of heterogeneity based on temporality and spatiality, potential therapies, and limitations DOI

Mengting Qian,

Zheng Wang, Hang Liu

et al.

Journal of Neuropathology & Experimental Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Spinal cord injury (SCI) constitutes a profound central nervous system disorder characterized by significant neurological dysfunction and sensory loss below the site. SCI elicits multifaceted cellular response in which proliferation of reactive astrocytes ensuing diversity their functions phenotypes play pivotal roles within microenvironment, especially during secondary phases condition. This review explores activation heterogeneity following SCI. It underscores necessity delineating among astrocyte subpopulations throughout phase Developing therapeutic strategies that capitalize on beneficial properties certain while mitigating adverse effects others could have implications for future clinical management

Language: Английский

Citations

0