Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement DOI

Bingfeng Wu,

Xiaohong Li, Rui Wang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 24, 2024

Abstract Biomimetic mineralized collagen (BMC) scaffolds represent an innovative class of bone‐repair biomaterials inspired by the natural biomineralization process in bone tissue. Owing to their favorable biocompatibility and mechanical properties, BMC have garnered significant attention tissue engineering. However, most studies overlooked importance bioactivity, resulting with suboptimal osteogenic potential. In this review, composition extracellular matrix (ECM) is discussed provide guidance for biomimetic mineralization. Subsequently, according detailed fabrication procedure scaffolds, substances that can regulate both biological activities summarized. Furthermore, a potential strategy developing superior properties engineering proposed.

Language: Английский

Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy DOI Creative Commons
Zhuoming Xu, Jintao Liu,

Hanyin Hu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 17, 2025

Osteoarthritis is one of the most common degenerative joint diseases, which seriously affects life middle-aged and elderly people. Traditional treatments such as surgical treatment systemic medication, often do not achieve expected or optimal results, leads to severe trauma a variety side effects. Therefore, there an urgent need develop novel therapeutic options overcome these problems. Hydrogels are widely used in biomedical tissue repairing platform for loading drugs, proteins stem cells. In recent years, smart-responsive hydrogels have achieved excellent results drug delivery systems osteoarthritis. This review focuses on advances endogenous stimuli (including enzymes, pH, reactive oxygen species temperature, etc.) responsive exogenous light, shear, ultrasound magnetism, osteoarthritis treatment. Finally, current limitations application future prospects smart summarized.

Language: Английский

Citations

0
Insights into the role of histone lysine demethylases in bone homeostasis and skeletal diseases: A review DOI
Ruiming Wen, Ruiqi Huang, Ke Xu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141807 - 141807

Published: March 5, 2025

Language: Английский

Citations

0
Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement DOI

Bingfeng Wu,

Xiaohong Li, Rui Wang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 24, 2024

Abstract Biomimetic mineralized collagen (BMC) scaffolds represent an innovative class of bone‐repair biomaterials inspired by the natural biomineralization process in bone tissue. Owing to their favorable biocompatibility and mechanical properties, BMC have garnered significant attention tissue engineering. However, most studies overlooked importance bioactivity, resulting with suboptimal osteogenic potential. In this review, composition extracellular matrix (ECM) is discussed provide guidance for biomimetic mineralization. Subsequently, according detailed fabrication procedure scaffolds, substances that can regulate both biological activities summarized. Furthermore, a potential strategy developing superior properties engineering proposed.

Language: Английский

Citations

1