Prevention and Treatment of Alzheimer's Disease Via the Regulation of the Gut Microbiota With Traditional Chinese Medicine DOI Creative Commons
Jingyu Long,

Jiani Zhang,

Xin Zeng

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(11)

Published: Nov. 1, 2024

Alzheimer's disease (AD) is caused by a variety of factors, and one the most important factors gut microbiota dysbiosis. An imbalance in mincrobiota have been shown to change concentrations lipopolysaccharide short-chain fatty acids. These microorganisms synthesize substances that can influence levels metabolites cause multiple diseases through immune response, acid metabolism, amino metabolism pathways. Furthermore, these metabolic changes promote formation β-amyloid plaques neurofibrillary tangles. Thus, microbiota-gut-brain axis plays an role AD development. In addition traditional therapeutic drugs such as donepezil memantine, Chinese medicines (TCMs) also showed significantly decrease severity symptoms suppress underlying related mechanisms. We searched for studies on effects different herbal monomers, single herbs, polyherbal formulas patients identified relevant pathways which affected AD. conclude improvements not only occurrence inflammatory reactions but reduce deposition central pathological products. Herbal monomers stronger effect improving pathology. Polyherbal extensive with Among formulas, anti-inflammatory essential main concern regarding use TCMs treating from viewpoint microbiota. hope this review will be helpful providing new ideas clinical application treatment

Language: Английский

Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy DOI
Xue Wen, Luming Qi, Kui Zhao

et al.

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 29, 2024

The onset and progression of type 2 diabetes mellitus (T2DM) are strongly associated with imbalances in gut bacteria, making the microbiome a new potential therapeutic focus. This commentary examines recent publication World Journal Diabetes . article explores association between T2DM microbiota, focus on pathophysiological changes related to dysbiosis. It proposes innovative microbiome-targeted strategies evaluates challenges future directions such approaches. editorial summarizes key points their discussion role elaborates influence specific microbial species disease through host–microbiota metabolic axis. provides insights for research gut-microbiota-based interventions T2DM.

Language: Английский

Citations

5
Identification and Therapeutic Potential of Polymethoxylated Flavones in Citri Reticulatae Pericarpium for Alzheimer’s Disease: Targeting Neuroinflammation DOI Creative Commons
Xinyu Wang,

Zirong Yi,

Yiming Zhang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 771 - 771

Published: Feb. 7, 2025

Neuroinflammation is a significant driving force in the pathogenesis and progression of central nervous system (CNS) disorders. Polymethoxylated flavones (PMFs), key lipid-soluble constituents Citri Reticulatae Pericarpium (CRP), exhibit excellent blood-brain barrier permeability anti-inflammatory properties, holding therapeutic potential for CNS However, specific bioactive components effects PMFs treating disorders are not well understood. This study employed comprehensive sequential metabolism approach to elucidate dynamic biotransformation vivo identified seven brain-targeting components. Subsequently, network pharmacology experimental validation were utilized explore mechanisms PMFs. The results suggested that have value Alzheimer's disease (AD)-like mice, with inhibition neuroinflammation likely being mechanism their anti-AD effects. Notably, sinensetin, tangeretin, nobiletin, 3,5,6,7,8,3',4'-heptamethoxyflavone as potent neuroinflammatory inhibitors. research elucidated chemical foundations PMFs, indicating treatments or nutritional supplements AD prevention treatment. Moreover, integrated triad metabolism, pharmacology, may serve promising strategy screening compounds herbs functional foods, elucidating mechanisms.

Language: Английский

Citations

0
Unlocking the neuroprotective secrets of natural products: a focus on the gut-brain axis DOI
Xiliang Yang, Die Hu,

R. Cheng

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

0
Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications DOI Creative Commons
Rengasamy Balakrishnan, Seungha Kang, Ji Yeon Lee

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

The human body contains approximately 100 trillion microorganisms, predominantly within the gastrointestinal tract, collectively called gut microbiota. Investigations have revealed bidirectional communication between microbiota and brain, characterized as "microbiota-gut-brain axis." This axis represents an important regulator of brain development function, immune system development, nutrient metabolism, making it a target for efforts to alleviate progression neurodegenerative diseases (NDDs). Despite extensive biomedical clinical research, our understanding causes, optimal treatment, NDDs remains limited. paper aims summarize available knowledge on role played by how is connected conditions; in particular, relationship gut-brain communications neuro-immune conditions reviewed. We discuss why communicates with this impacts neurodegeneration. Next, we examine alterations microbiota, response, changes associated dysbiosis. Finally, highlight preclinical evidence probiotics, prebiotics, fecal transplantation, dietary supplements, natural drugs, exercise intervention potential therapeutic approaches that could lead new treatment paradigm NDDs.

Language: Английский

Citations

3
Prevention and Treatment of Alzheimer's Disease Via the Regulation of the Gut Microbiota With Traditional Chinese Medicine DOI Creative Commons
Jingyu Long,

Jiani Zhang,

Xin Zeng

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(11)

Published: Nov. 1, 2024

Alzheimer's disease (AD) is caused by a variety of factors, and one the most important factors gut microbiota dysbiosis. An imbalance in mincrobiota have been shown to change concentrations lipopolysaccharide short-chain fatty acids. These microorganisms synthesize substances that can influence levels metabolites cause multiple diseases through immune response, acid metabolism, amino metabolism pathways. Furthermore, these metabolic changes promote formation β-amyloid plaques neurofibrillary tangles. Thus, microbiota-gut-brain axis plays an role AD development. In addition traditional therapeutic drugs such as donepezil memantine, Chinese medicines (TCMs) also showed significantly decrease severity symptoms suppress underlying related mechanisms. We searched for studies on effects different herbal monomers, single herbs, polyherbal formulas patients identified relevant pathways which affected AD. conclude improvements not only occurrence inflammatory reactions but reduce deposition central pathological products. Herbal monomers stronger effect improving pathology. Polyherbal extensive with Among formulas, anti-inflammatory essential main concern regarding use TCMs treating from viewpoint microbiota. hope this review will be helpful providing new ideas clinical application treatment

Language: Английский

Citations

0