cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 105, P. 102691 - 102691

Published: Feb. 13, 2025

Language: Английский

Carnosic Acid Directly Targets STING C‐Terminal Tail to Improve STING‐Mediated Inflammatory Diseases

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract cGAS (cyclic GMP‐AMP synthase)‐STING (stimulator of interferon genes) signaling plays a vital role in innate immunity, while its deregulation may lead to wide variety autoinflammatory and autoimmune diseases. It is essential identify specifically effective compounds inhibit the signaling. Herein, it shown that carnosic acid (CA), an active ingredient medicinal plant Rosmarinus officinalis L ., suppressed cGAS‐STING pathway activation subsequent inflammatory responses. Mechanistically, CA directly bound STING C‐terminal tail (CTT), impeded recruitment TANK‐binding kinase 1 (TBK1) onto signalosome, thereby blocking phosphorylation regulatory factor 3 (IRF3) nuclear translocation. Importantly, dramatically attenuated STING‐mediated responses vivo. Consistently, has salient ameliorative effect on disease model mediated by Trex1 deficiency, via inhibition Notably, study further indicates phenolic hydroxyl groups are for CA‐mediated inhibitory activity. Collectively, results thus as one crucial targets mediating CA's anti‐inflammatory activity, reveal CTT be novel promising target drug development.

Language: Английский

ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury

Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(4)

Published: April 1, 2025

Language: Английский