STAT3 Orchestrates Immune Dynamics in Hepatocellular Carcinoma: A Pivotal Nexus in Tumor Progression

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104620 - 104620

Published: Jan. 1, 2025

Language: Английский

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Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

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Exosome-based miRNA delivery: Transforming cancer treatment with mesenchymal stem cells

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 28, P. 558 - 572

Published: Feb. 13, 2025

Language: Английский

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Application of Machine Learning (ML) approach in discovery of novel drug targets against Leishmania: A computational based approach

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: 117, P. 108423 - 108423

Published: March 12, 2025

Language: Английский

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A vascular heterogeneity-orienting TACE strategy addresses peripheral tumor and avascular deep tumor for complete hepatocellular carcinoma clearance

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161996 - 161996

Published: March 1, 2025

Language: Английский

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Nanomedicine in the Diagnosis and Treatment of Pancreatic Cancer

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 449 - 449

Published: March 31, 2025

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with increasing incidence and mortality rates, highlighting the urgent need for early diagnosis treatment. However, of PDAC extremely challenging due to atypical symptoms or absence noticeable symptoms. As a result, many patients are diagnosed local metastasis, even who eligible surgical resection have high postoperative recurrence rate. Consequently, chemotherapy remains primary treatment PDAC. unique biological characteristics not only promote tumor progression metastasis but also often lead chemoresistance, significant barrier successful Recently, nanomaterials garnered attention as promising materials diagnosing treating PDAC, showing great potential in cancer therapy, imaging, drug delivery. Novel targeted nanomedicines, which encapsulate drugs gene therapy products, offer advantages overcoming resistance. These nanomedicines provide innovative solutions limitations conventional improve selectivity cells enhance therapeutic outcomes. Current research focused on development advanced such liposomes, nanotubes, polymer-lipid hybrid systems, aimed at making more effective longer lasting. This review provides detailed overview various utilized outlines future directions their key breakthroughs.

Language: Английский

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Roles of anoikis in hepatocellular carcinoma therapy and the assessment of anoikis-regulatory molecules as therapeutic targets

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

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Evaluation of hepatic cancer stem cells (CD73+, CD44+, and CD90+) induced by diethylnitrosamine in male rats and treatment with biologically synthesized silver nanoparticles

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 15, 2025

Language: Английский

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The regulatory role of the circELMOD3-associated ceRNA network in the progression and prognosis of hepatocellular carcinoma

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Background Our previously research has validated the effect of circELMOD3 on HCC tumor inhibition. However, further investigations are warranted to investigate prognostic significance in and its regulation via competitive endogenous RNA (ceRNA) network. Methods The gene expression profiles clinical information were obtained from Cancer Genome Atlas (TCGA-LIHC) International Consortium (ICGC). Base circMine, miRWalk TargetScan database, we constructed circELMOD3-miRNA-mRNA Univariate Cox least absolute shrinkage selection operator (LASSO) regression analysis was used model. Additionally, Gene set enrichment (GSEA) conducted for prognostic-related genes. Finally, levels genes proteins respectively assessed by quantitative real-time polymerase chain reaction (qRT-PCR) Western blotting. Results We a ceRNA network comprising circELMOD3, 5 miRNAs, 274 mRNAs. From this network, identified four prognostication-relation develop survival prediction In TCGA-LIHC training set, area under curve (AUC) values one-, three- five-years 0.734, 0.718 0.707, respectively, then model database. displayed that these primary enriched pathways related cell cycle regulation. finding demonstrated could affect relative N-cadherin, E-cadherin, CDK4, CDK6 CyclinD1 proteins. Conclusion novel based comprehensively characterizing prognosis HCC, providing valuable insights therapy HCC.

Language: Английский

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Green Synthesis of Nickel Oxide Nanoparticles Using Pistacia atlantica Leaves Extract: Characterization, Catalytic Activity for Synthesis of Pyrazolo[3,4-b]pyridines, and Investigation of Its Anti-hepatic Cancer Effects

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

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