Traditional Chinese Medicine for Inhibiting Ferroptosis in Ischemic‐Related Diseases DOI
Yukun Zhang,

Yao Yang,

Qiaoling Zhang

et al.

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2025, Volume and Issue: 136(6)

Published: April 28, 2025

ABSTRACT Ischemic‐related diseases, such as myocardial infarction and stroke, are primarily driven by a deficit in oxygen supply leading to cellular damage death. Ferroptosis has emerged an important mechanism contributing the progression of ischemic injury, characterized iron‐dependent lipid peroxidation. This review aims provide comprehensive overview significant mechanisms underlying ferroptosis conditions explores potential effects traditional Chinese medicines (TCMs) their extracts. Numerous compounds extracted from TCMs, including flavonoids, polyphenols terpenes, exhibit potent antiferroptotic activating nuclear factor erythroid 2–related 2, upregulating glutathione peroxidase 4, inhibiting peroxidation so on. These properties render TCMs promising candidate for developing novel therapeutic strategies. underscores importance investigating interactions between within context diseases. findings valuable insights future research identify targets associated with regulation, thereby expanding pharmacological perspective treating diseases revealing Additionally, this highlights relevance integrating modern medical approaches addressing complex health issues.

Language: Английский

Identification of Phenolics and Structural Compounds of Different Agro-Industrial By-Products DOI Creative Commons
Óscar Benito-Román, Rodrigo Melgosa, José M. Benito

et al.

Agriculture, Journal Year: 2025, Volume and Issue: 15(3), P. 299 - 299

Published: Jan. 30, 2025

This study provides a comprehensive analysis of the composition onion peels, tomato and pistachio green hulls, with focus on their structural bioactive compounds. Onion regardless cultivar, were found to be rich in quercetin its derivatives, along other flavonoids pectin. Tomato peels emerged as notable source naringenin (0.52 mg/g ethanol extract) rutin (0.24 water showed an unexpectedly high lignin content, comprising nearly 50% components. Pistachio hulls demonstrated extractive content (63.4 g/100 g), 73% which water-soluble. Protocatechuic acid, rutin, derivatives dominant phenolic compounds extract, while luteolin was most abundant extract. Regarding composition, shared similarities, exhibiting (53.4% 33.8%, respectively) uronic acids (10–15%). In contrast, characterized by levels glucans (around 38%) galacturonic acid (33%). The insights from this pave way for design sustainable efficient extraction processes, enabling sequential recovery valuable promoting valorization these agro-industrial by-products. Additionally, evaluated sources pectin using two methods: conventional subcritical extraction. results revealed significant differences (53–68% acid) degree esterification (79–92%) compared commercial (72.8% 68% esterification), highlighting influence raw material method final properties

Language: Английский

Citations

0
Naringenin inhibits ferroptosis to reduce radiation-induced lung injury: insights from network Pharmacology and molecular docking DOI Creative Commons
Jun‐Lin Jiang,

Xianhui Deng,

Chuanlai Xu

et al.

Pharmaceutical Biology, Journal Year: 2025, Volume and Issue: 63(1), P. 1 - 10

Published: Feb. 19, 2025

Context Naringenin is a natural flavanone with potent pharmacological properties. It has demonstrated therapeutic potential in treating various diseases and organ injuries, including radiation-induced lung injury (RILI). Ferroptosis newly type of cell death, naringenin been shown to attenuates ferroptosis.

Language: Английский

Citations

0
CDC42 Regulates the ERK Pathway to Improve Oxygen‒Glucose Deprivation/Reoxygenation-Induced Neural Oxidative Stress and Apoptosis DOI
Lina Hao, Hongmei Jia, Feifei Wei

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Macrophage Membrane Coated Manganese Dioxide Nanoparticles Loaded with Rapamycin Alleviate Intestinal Ischemia-Reperfusion Injury by Reducing Oxidative Stress and Enhancing Autophagy DOI Creative Commons
Ren Sheng, Wei Wang, Weian Zeng

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3541 - 3557

Published: March 1, 2025

Intestinal ischemia-reperfusion (I/R) injury is a common and severe clinical issue. With high morbidity mortality, it burdens patients the healthcare system. Despite efforts in medical research, current treatment options are unsatisfactory, urging novel therapeutic strategies. Oxidative stress dysregulated autophagy play pivotal roles pathogenesis of I/R injury, damaging intestinal tissues disrupting normal functions. The aim this study to fabricate macrophage membrane-coated manganese dioxide nanospheres loaded with rapamycin [Ma@(MnO₂+RAPA)] for alleviating injury. We engineered honeycomb MnO2 coated membrane act as drug delivery system, encapsulating RAPA. In vitro OGD/R model IEC-6 cells vivo mouse models were used. Targeting ability was evaluated through in-vivo imaging Effects on cell viability, reactive oxygen species (ROS) levels, generation, inflammatory factors, apoptosis, autophagy, biocompatibility detected by methods such MTT assay, fluorescence microscopy, ELISA kit, TUNEL Western blotting histological analysis. study, Ma@(MnO₂+RAPA) efficiently deliver RAPA damaged exhibited good ROS-responsive release. Our data showed that reduced ROS, increased O₂, inhibited inflammation, promoted while reducing apoptosis cells. model, significantly Chiu's score, improved tight conjunction proteins, decreased levels cytokines oxidative stress. released from Ma@(MnO₂+RAPA), enhanced expression autophagy-regulated proteins p62, Beclin-1, LC3II. safety confirmed analysis biochemical detection mice. results demonstrated alleviated stress, promoting inhibiting inflammation. This offers potential strategy

Language: Английский

Citations

0
Traditional Chinese Medicine for Inhibiting Ferroptosis in Ischemic‐Related Diseases DOI
Yukun Zhang,

Yao Yang,

Qiaoling Zhang

et al.

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2025, Volume and Issue: 136(6)

Published: April 28, 2025

ABSTRACT Ischemic‐related diseases, such as myocardial infarction and stroke, are primarily driven by a deficit in oxygen supply leading to cellular damage death. Ferroptosis has emerged an important mechanism contributing the progression of ischemic injury, characterized iron‐dependent lipid peroxidation. This review aims provide comprehensive overview significant mechanisms underlying ferroptosis conditions explores potential effects traditional Chinese medicines (TCMs) their extracts. Numerous compounds extracted from TCMs, including flavonoids, polyphenols terpenes, exhibit potent antiferroptotic activating nuclear factor erythroid 2–related 2, upregulating glutathione peroxidase 4, inhibiting peroxidation so on. These properties render TCMs promising candidate for developing novel therapeutic strategies. underscores importance investigating interactions between within context diseases. findings valuable insights future research identify targets associated with regulation, thereby expanding pharmacological perspective treating diseases revealing Additionally, this highlights relevance integrating modern medical approaches addressing complex health issues.

Language: Английский

Citations

0