A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent DOI Open Access
Shafiul Haque, Darin Mansor Mathkor, Sajad Ahmad Bhat

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 39(1)

Published: Dec. 24, 2024

ABSTRACT Berberine, an isoquinoline alkaloid derived from various medicinal plants, emerges as a potential therapeutic agent against diverse human diseases. It has particularly shown notable anticancer efficacy breast, colorectal, lung, prostate, and liver cancer. Berberine results in inhibition of cancer cell proliferation, induction apoptosis, suppressing angiogenesis, positioning it versatile, multitargeted tool Notably, berberine enhances the effectiveness conventional chemotherapeutic drugs, mitigating associated drug resistance. Mechanistically, been to exert its by targeting molecules like nuclear factor‐kappa B (NF‐κB), mitogen‐activated protein kinases (MAPKs), phosphoinositide 3‐kinase (PI3K)/Akt, thereby inhibiting survival pathways promoting apoptosis cells. Moreover, influences expression tumor suppressor genes, curtails migration invasion, modulates tumour microenvironment. Despite promising preclinical evidence, further research is essential comprehensively elucidate mechanisms action evaluate safety clinical settings. In present review, we have highlighted pharmacokinetics, biosynthesis, recent work done pertaining berberine's strong activity. We also emphasised on being nanoformulations berberine, which aim improve stability bioavailability.

Language: Английский

Organoid models of ovarian cancer: resolving immune mechanisms of metabolic reprogramming and drug resistance DOI Creative Commons
Lanyue Zhang,

Jiangnan Zhao,

Changqing Su

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Metabolic reprogramming is a hallmark of ovarian cancer, enabling tumor progression, immune evasion and drug resistance. The microenvironment (TME) further shapes metabolic adaptations, cancer cells to withstand hypoxia nutrient deprivation. While organoid models provide physiologically relevant platform for studying these processes, they still lack vascular components, limiting their ability fully recapitulate metabolism responses. In this study, we investigated the key mechanisms involved in focusing on glycolysis, lipid amino acid metabolism. We integrated metabolomic analyses sensitivity assays explore metabolic-TME interactions using patient-derived, adult stem cell-derived iPSC-derived organ tissues. Among these, found that play central role progression chemotherapy identified methylglyoxal (MGO)-mediated BRCA2 dysfunction as driver escape, sphingolipid signaling proliferation kynurenine CD8+ T cell suppression. addition, PI3K/AKT/mTOR Wnt/β-catenin pathways promote chemoresistance through adaptation. By elucidating link between evasion, study identifies vulnerabilities potential targets cancer. Our findings support development metabolically targeted therapies increase utility organoid-based precision medicine models.

Language: Английский

Citations

0
Saponins from Astragalus membranaceus (Fisch.) Bge Alleviated Neuronal Ferroptosis in Alzheimer’s Disease by Regulating the NOX4/Nrf2 Signaling Pathway DOI
Min Wang, Mengmeng Li,

Yi-Kai Jiang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Alzheimer's disease (AD) is a chronic neurodegenerative of the central nervous system caused by loss neuronal or myelin function, accompanied ferroptosis. Astragalus membranaceus (Fisch.) Bge. (A. membranaceus) one China's homologous lists medicines and food, its active component saponins have neuroprotective effects. This study examines mechanism from A. (AS) in treating AD. UPLC-Q-TOF-MS analyzed composition AS. Ferroptosis models were established to evaluate anti-AD efficacy. As result, AS treatment inhibited ferroptosis SAMP8 mice restoring iron homeostasis lipid peroxidation (LPO) balance brain, thereby improving cognitive impairment pathological damage. Mechanistically, reduced Fe2+, MDA, ROS levels enhanced protein SLC7A11, GPX4, FTH1, FPN1. NADPH oxidase 4 (NOX4) overexpression revealed that NOX4, reducing NOX4 stability regulating NOX4/Nrf2 pathway erastin-injured HT22 cells significantly alleviating Therefore, improved AD rebuilding LPO brain. has potential be promising candidate medicine for

Language: Английский

Citations

0
The Role of Medicinal Plants in Modulating Epigenetic Mechanisms: Implications for Cancer Prevention and Therapy DOI

Khadra Afaf Bendrihem,

Aicha Mouane,

Manel Azzi

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Cancer remains a significant global health challenge, with its progression driven by both genetic mutations and reversible epigenetic modifications. This review highlights the potential of phytochemicals to modulate mechanisms for cancer prevention treatment. Natural compounds such as quercetin, EGCG, genistein, β-elemene interact key processes DNA methylation, histone modifications, non-coding RNA regulation. These enable reactivation tumor suppressor genes, increased sensitivity conventional therapy mitigation drug resistance. For instance, EGCG improves efficacy cisplatin altering methylation patterns, while genistein influences breast through HER2 pathway However, challenges low bioavailability, variability in compound composition, need robust clinical validation remain. Further high-quality trials are required confirm safety these therapy.

Language: Английский

Citations

0
Utilization of natural products in diverse pathogeneses of diseases associated with single or double DNA strand damage repair DOI Creative Commons

Jiali Liang,

Wanqing Liu, Tong Zhang

et al.

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 7, 2025

Abstract The appearance of DNA damage often involves the participation related enzymes, which can affect onset and development various diseases. Several natural active compounds have been found to efficiently adjust activity crucial enzymes associated with single or double-strand damage, thus demonstrating their promise in treating This paper provides an in-depth examination summary these modulation mechanisms, leading a thorough review subject. connection between disease is explored through analysis structural characteristics compounds. By reviewing how different scholarly sources describe identical structures using varied terminology, this study also delves into effects on enzyme regulation. offers potentially be used therapeutically influence key activities expression levels, turn process repair (DDR). These shown not only reduce occurrence but boost efficiency processes, presenting new therapeutic opportunities for conditions such as cancer other pathologies. Future research should focus clarifying exact mechanisms maximize clinical utility support creation novel approaches prevention treatment. Graphical abstract

Language: Английский

Citations

0
LINC00704 facilitates cell proliferation, migration, and invasion via miR-323a-3p/SLC44A1 axis in epithelial ovarian cancer DOI Creative Commons
Xiaohua Kong, Lei Lei, Zeyi Ma

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 29, 2025

Epithelial ovarian cancer (EOC) is the most common subtype of and a highly recurrent lethal malignancy female reproductive system. Accumulating evidence has indicated that long non-coding RNAs (lncRNAs) play pivotal roles in tumorigenesis. Long intergenic non-protein coding RNA 704 (LINC00704) been recognized as an oncogenic lncRNA several malignancies. However, its specific role EOC remains unclear. In this study, RT-qPCR revealed upregulation LINC00704 tissues cell lines. CCK-8 EdU assays showed knockdown inhibited proliferation. Flow cytometry analysis demonstrated silencing induced cycle arrest apoptosis. Transwell inhibitory effects on migration invasion. Mechanistically, bioinformatics analysis, pull-down, luciferase reporter immunoprecipitation upregulated SLC44A1 expression by competitively binding to miR-323a-3p. Moreover, rescue experiments overexpression could reverse silencing-mediated malignant behaviors cells. conclusion, promotes aggressiveness vitro regulating miR-323a-3p/SLC44A1 axis.

Language: Английский

Citations

0
A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent DOI Open Access
Shafiul Haque, Darin Mansor Mathkor, Sajad Ahmad Bhat

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 39(1)

Published: Dec. 24, 2024

ABSTRACT Berberine, an isoquinoline alkaloid derived from various medicinal plants, emerges as a potential therapeutic agent against diverse human diseases. It has particularly shown notable anticancer efficacy breast, colorectal, lung, prostate, and liver cancer. Berberine results in inhibition of cancer cell proliferation, induction apoptosis, suppressing angiogenesis, positioning it versatile, multitargeted tool Notably, berberine enhances the effectiveness conventional chemotherapeutic drugs, mitigating associated drug resistance. Mechanistically, been to exert its by targeting molecules like nuclear factor‐kappa B (NF‐κB), mitogen‐activated protein kinases (MAPKs), phosphoinositide 3‐kinase (PI3K)/Akt, thereby inhibiting survival pathways promoting apoptosis cells. Moreover, influences expression tumor suppressor genes, curtails migration invasion, modulates tumour microenvironment. Despite promising preclinical evidence, further research is essential comprehensively elucidate mechanisms action evaluate safety clinical settings. In present review, we have highlighted pharmacokinetics, biosynthesis, recent work done pertaining berberine's strong activity. We also emphasised on being nanoformulations berberine, which aim improve stability bioavailability.

Language: Английский

Citations

0