Mangiferin Promotes Porcine Oocyte Maturation and Delays the Postovulatory Aging Process by Up-Regulating Nrf2 Levels DOI

X-M Yuan,

Hongchao Ji, Yuhao Zhang

et al.

Published: Jan. 1, 2024

Language: Английский

Mangiferin promotes porcine oocyte maturation and delays the postovulatory aging process by up-regulating NRF2 levels DOI

Xiu‐Wen Yuan,

Hongchao Ji, Yuhao Zhang

et al.

Theriogenology, Journal Year: 2025, Volume and Issue: 239, P. 117384 - 117384

Published: March 10, 2025

Language: Английский

Citations

0
The influence and mechanisms of exogenous aryl hydrocarbon receptor ligands on the viability of mouse germ cells DOI

Yimin Cheng,

Yebin Yang,

Chen Chen

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111478 - 111478

Published: March 1, 2025

Language: Английский

Citations

0
Interplay of Ferroptosis, Cuproptosis, Autophagy and Pyroptosis in Male Infertility: Molecular Crossroads and Therapeutic Opportunities DOI Open Access

Dong-Zhen Cai,

Junda Li, Peng Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3496 - 3496

Published: April 8, 2025

Male infertility is intricately linked to dysregulated cell death pathways, including ferroptosis, cuproptosis, pyroptosis, and autophagy. Ferroptosis, driven by iron-dependent lipid peroxidation through the Fenton reaction inactivation of GPX4/Nrf2/SLC7A11 axis, disrupts spermatogenesis under conditions oxidative stress, environmental toxin exposure, or metabolic disorders. Similarly, cuproptosis—characterized mitochondrial dysfunction disulfide stress due copper overload—exacerbates germ apoptosis via FDX1 activation NADPH depletion. Pyroptosis, mediated NLRP3 inflammasome gasdermin D, amplifies testicular inflammation loss IL-1β/IL-18 release, particularly in response insults. Autophagy maintains homeostasis clearing damaged organelles proteins; however, its dysregulation impairs sperm maturation compromises blood–testis barrier integrity. These pathways intersect shared regulators; reactive oxygen species mTOR modulate autophagy–pyroptosis balance, while Nrf2 bridge ferroptosis–cuproptosis crosstalk. Therapeutic interventions targeting these mechanisms have shown promise preclinical models. However, challenges persist, tissue-specific roles isoforms, off-target effects pharmacological inhibitors, transgenerational epigenetic impacts toxins. This review synthesizes current molecular insights into implicated male infertility, emphasizing their interplay translational potential for restoring spermatogenic function.

Language: Английский

Citations

0
Mangiferin Promotes Porcine Oocyte Maturation and Delays the Postovulatory Aging Process by Up-Regulating Nrf2 Levels DOI

X-M Yuan,

Hongchao Ji, Yuhao Zhang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0