Lycopene prevents the intestinal toxicity caused by cyclophosphamide via NCOA4-induced ferroptosis pathway DOI
Xiaoran Liu, Yun Dai,

Yupei Yao

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106862 - 106862

Published: April 28, 2025

Language: Английский

Palliative potential of genistein to counteract endosulfan instigated colon toxicity via regulating TLR4/MyD88, JAK1/STAT3 and NF-κB pathway: A biochemical and histological approach DOI
Khalid J. Alzahrani,

Mahmoud El Safadi,

Khalaf F. Alsharif

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102730 - 102730

Published: Jan. 10, 2025

Language: Английский

Citations

0
New insights into ovarian regression-related mitochondrial dysfunction in the late-laying period DOI Creative Commons
Tiantian Gu, Jinyu Liu, Tao Zeng

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104938 - 104938

Published: Feb. 22, 2025

Language: Английский

Citations

0
UBA52 Mediates ribosomal DNA stability under hexavalent chromium exposure in occupational workers and cellular models DOI Creative Commons
Huadong Xu, Fan Wu,

Chuyan Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 293, P. 118047 - 118047

Published: March 1, 2025

Language: Английский

Citations

0
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis DOI
Yao Zhou, Wen‐Ying Chen, Shiyu Feng

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Visual indicator for the detection of methylmercury in blood: A critical biomarker for dietary exposure assessment DOI Creative Commons
Yan Guo, Bing-chan Ma, Wen‐Qi Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 295, P. 118157 - 118157

Published: April 1, 2025

Methylmercury (MeHg), a significant dietary exposure biomarker, poses substantial threat to public health, primarily due the consumption of aquatic foods. Current detection methods are complex and unsuitable for on-site testing, necessitating development simple sensitive biosensor rapid screening. This study addresses this challenge by developing highly whole-cell detecting organic mercury in blood samples, offering both visual qualitative colorimetric quantitative assessments. We engineered based on mer operon deoxyviolacein (DV) pigment, optimizing its performance adjusting MerB expression level, screening host cells, incorporating biosurfactant rhamnolipid. The optimized achieved limit 0.195 nM exhibited linear response range 0.195-1.563 MeHg. is significantly below Provisional Tolerable Weekly Intake (PTWI) 1.6 μg/kg body weight per week established Joint FAO/WHO Expert Committee Food Additives (JECFA), ensuring reliable MeHg at concentrations well within safety threshold. Notably, demonstrated broad-spectrum capabilities, including natural synthetic organomercurials, which crucial assessing risks from various sources. advances novel detection, highlighting potential as critical tool contributing understanding food health.

Language: Английский

Citations

0
Interplay of Ferroptosis, Cuproptosis, Autophagy and Pyroptosis in Male Infertility: Molecular Crossroads and Therapeutic Opportunities DOI Open Access

Dong-Zhen Cai,

Junda Li, Peng Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3496 - 3496

Published: April 8, 2025

Male infertility is intricately linked to dysregulated cell death pathways, including ferroptosis, cuproptosis, pyroptosis, and autophagy. Ferroptosis, driven by iron-dependent lipid peroxidation through the Fenton reaction inactivation of GPX4/Nrf2/SLC7A11 axis, disrupts spermatogenesis under conditions oxidative stress, environmental toxin exposure, or metabolic disorders. Similarly, cuproptosis—characterized mitochondrial dysfunction disulfide stress due copper overload—exacerbates germ apoptosis via FDX1 activation NADPH depletion. Pyroptosis, mediated NLRP3 inflammasome gasdermin D, amplifies testicular inflammation loss IL-1β/IL-18 release, particularly in response insults. Autophagy maintains homeostasis clearing damaged organelles proteins; however, its dysregulation impairs sperm maturation compromises blood–testis barrier integrity. These pathways intersect shared regulators; reactive oxygen species mTOR modulate autophagy–pyroptosis balance, while Nrf2 bridge ferroptosis–cuproptosis crosstalk. Therapeutic interventions targeting these mechanisms have shown promise preclinical models. However, challenges persist, tissue-specific roles isoforms, off-target effects pharmacological inhibitors, transgenerational epigenetic impacts toxins. This review synthesizes current molecular insights into implicated male infertility, emphasizing their interplay translational potential for restoring spermatogenic function.

Language: Английский

Citations

0
Synergistic Effects of Copper and Bile Acids on Cholesterol Reduction in Eggs of Laying Hens DOI Creative Commons
Han Chen, Yifan Li,

Shoukang Cao

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105202 - 105202

Published: April 1, 2025

Language: Английский

Citations

0
Lycopene prevents the intestinal toxicity caused by cyclophosphamide via NCOA4-induced ferroptosis pathway DOI
Xiaoran Liu, Yun Dai,

Yupei Yao

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106862 - 106862

Published: April 28, 2025

Language: Английский

Citations

0