Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review DOI Open Access
Matteo Naso, Chiara Trincianti, Maria Angela Tosca

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1476 - 1476

Published: April 27, 2025

Quercetin, a natural flavonoid, present in various vegetables and fruits, has garnered increasing attraction for its potential antiallergic properties. Its broad-spectrum activity depends on anti-inflammatory, immunomodulatory, antioxidant effects, which target the critical pathways involved type 2-driven allergic inflammation. Quercetin inhibits mast cell degranulation, reduces production of histamine pro-inflammatory cytokines, restores homeostasis immune system by modulating Th1/Th2 Treg/Th17 balances. Additionally, properties help to dampen oxidative stress, factor pathophysiology diseases. In vitro studies have consistently demonstrated quercetin's ability suppress reactions. contrast, vivo studies, particularly murine models rhinitis, confirmed efficacy relieving symptoms (such as nasal itching, sneezing, rhinorrhea, congestion) dampening 2 mucosal Preclinical evidence also supports therapeutic asthma, conjunctivitis, atopic dermatitis, food allergies. However, human are still scarce, only two clinical trials investigated quercetin monotherapy. Both reported promising results, including symptom reduction improved quality life, though larger, randomized needed validate these findings. Some other multicomponent products that contain quercetin. This review aimed report discuss most recent application models. It provides comprehensive overview highlighting an agent supplements manage patients with Moreover, this introduces new phospholipids formulation may represent keystone use. The literature search was based PubMed consultation considering (last five years) publications using keywords "quercetin disease" system".

Language: Английский

Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review DOI Open Access
Matteo Naso, Chiara Trincianti, Maria Angela Tosca

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1476 - 1476

Published: April 27, 2025

Quercetin, a natural flavonoid, present in various vegetables and fruits, has garnered increasing attraction for its potential antiallergic properties. Its broad-spectrum activity depends on anti-inflammatory, immunomodulatory, antioxidant effects, which target the critical pathways involved type 2-driven allergic inflammation. Quercetin inhibits mast cell degranulation, reduces production of histamine pro-inflammatory cytokines, restores homeostasis immune system by modulating Th1/Th2 Treg/Th17 balances. Additionally, properties help to dampen oxidative stress, factor pathophysiology diseases. In vitro studies have consistently demonstrated quercetin's ability suppress reactions. contrast, vivo studies, particularly murine models rhinitis, confirmed efficacy relieving symptoms (such as nasal itching, sneezing, rhinorrhea, congestion) dampening 2 mucosal Preclinical evidence also supports therapeutic asthma, conjunctivitis, atopic dermatitis, food allergies. However, human are still scarce, only two clinical trials investigated quercetin monotherapy. Both reported promising results, including symptom reduction improved quality life, though larger, randomized needed validate these findings. Some other multicomponent products that contain quercetin. This review aimed report discuss most recent application models. It provides comprehensive overview highlighting an agent supplements manage patients with Moreover, this introduces new phospholipids formulation may represent keystone use. The literature search was based PubMed consultation considering (last five years) publications using keywords "quercetin disease" system".

Language: Английский

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