Hybrid Neural network and machine learning models with improved optimization method for gut microbiome effects on the sleep quality in patients with endometriosis DOI
Hui Deng, Li Pan

Computer Methods and Programs in Biomedicine, Journal Year: 2025, Volume and Issue: 267, P. 108776 - 108776

Published: April 26, 2025

Language: Английский

The heart of the matter: How gut microbiota-targeted interventions influence cardiovascular diseases DOI

Mohammad Abavisani,

Pourya Tafti,

Niloofar Khoshroo

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155931 - 155931

Published: March 1, 2025

Language: Английский

Citations

0
A Novel Frontier in Gut–Brain Axis Research: The Transplantation of Fecal Microbiota in Neurodegenerative Disorders DOI Creative Commons
Majid Eslami, Zarifeh Adampour,

Bahram Fadaee Dowlat

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 915 - 915

Published: April 9, 2025

The gut–brain axis (GBA) represents a sophisticated bidirectional communication system connecting the central nervous (CNS) and gastrointestinal (GI) tract. This interplay occurs primarily through neuronal, immune, metabolic pathways. Dysbiosis in gut microbiota has been associated with multiple neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s (AD), sclerosis (MS), amyotrophic lateral (ALS). In recent years, fecal transplantation (FMT) gained attention an innovative therapeutic approach, aiming to restore microbial balance while influencing neuroinflammatory review explores mechanisms by which FMT impacts axis. Key areas of focus include its ability reduce neuroinflammation, strengthen barrier integrity, regulate neurotransmitter production, reinstate diversity. Both preclinical clinical studies indicate that can alleviate motor cognitive deficits PD AD, lower markers MS, enhance respiratory neuromuscular functions ALS. Despite these findings, several challenges remain, including donor selection complexities, uncertainties about long-term safety, inconsistencies outcomes. Innovations synthetic communities, engineered probiotics, AI-driven analysis microbiome hold potential improve precision effectiveness managing conditions. Although presents considerable promise development, widespread application for diseases requires thorough validation well-designed, large-scale trials. It is essential establish standardized protocols, refine processes, deepen our understanding molecular behind efficacy.

Language: Английский

Citations

0
The role of CRISPR-Cas9 and CRISPR interference technologies in the treatment of autoimmune diseases DOI

Zahra Khademi,

Negar Mottaghi-Dastjerdi, Hamed Morad

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103816 - 103816

Published: April 1, 2025

Language: Английский

Citations

0
Lacticaseibacillus casei IDCC 3451 alleviates cognitive and behavioral functions by reshaping the gut microbiome and regulating intestinal barrier integrity in chronic stress animal models DOI Creative Commons
Anna Kang,

Ju Young Eor,

Junbeom Lee

et al.

Current Research in Food Science, Journal Year: 2025, Volume and Issue: unknown, P. 101051 - 101051

Published: April 1, 2025

Lacticaseibacillus casei IDCC 3451 (3451) was evaluated for its effects on the gut-brain axis using Caenorhabditis elegans (C. elegans) and mouse models of stress inflammation. In C. elegans, extended lifespans by 25 %, improved motility, chemotaxis, enhanced survival under pathogen challenge, reduced amyloid beta accumulation 42 %. Transcriptomic profiling revealed upregulation genes involved in neurotransmitter signaling serine/threonine pathways. unpredictable chronic mild (UCMS) model, administration increased time spent center open field 65 % immobility forced swim test 32 indicating anxiolytic antidepressant effects. Serum levels aspartate aminotransferase (AST) gamma-glutamyl transferase (GGT) were decreased 18 24 respectively. Additionally, restored expressions 5HT1AR, GABAR, tight junction proteins, including ZO-1 Claudin1. Metabolomic analysis showed glycine palmitic acid levels, associated with an abundance Ruminococcus Akkermansia. dextran sulfate sodium (DSS)-induced colitis disease activity index 36 colon histology, goblet cell preservation, upregulated IL-10 expression. Threonine also correlated a higher Coprococcus. These findings demonstrate that behavioral intestinal outcomes through coordinated modulation host signaling, metabolite production, gut microbial composition, highlighting therapeutic potential managing IBD neurobehavioral disorders.

Language: Английский

Citations

0
Hybrid Neural network and machine learning models with improved optimization method for gut microbiome effects on the sleep quality in patients with endometriosis DOI
Hui Deng, Li Pan

Computer Methods and Programs in Biomedicine, Journal Year: 2025, Volume and Issue: 267, P. 108776 - 108776

Published: April 26, 2025

Language: Английский

Citations

0