Xiasangju alleviates hepatic insulin resistance in db/db mice via AMPK pathway: Mechanisms and active components study DOI
Yongcheng An, Hongbin Zhao, Changhao He

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114675 - 114675

Published: April 25, 2025

Language: Английский

Doxorubicin promotes NK cell dysfunction and induces acute liver injury through kynurenine-AhR axis DOI
Biqiu Tang, Huan Ouyang,

Shuping Zheng

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114489 - 114489

Published: March 20, 2025

Language: Английский

Citations

0
Prediction of potential targets of aloe-emodin in the treatment of hepatocellular carcinoma using network pharmacology combined with bioinformatics DOI Creative Commons
Jianfeng Wei,

Haosong Chen,

Maoqi Xu

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 4, 2025

Hepatocellular carcinoma is one of the most common and malignant tumors worldwide. Although aloe-emodin (AE), a pure natural drug, can effectively kill hepatocellular cells, its internal molecular mechanism has not been fully elucidated. In this study, anti-hepatocellular targets AE were predicted using network pharmacology bioinformatics. The differentially expressed genes between normal tissues first identified then further intersected with potential pharmacological target for subsequent analysis. Moreover, enriched analyzed to identify downstream pathways. binding ability interaction above drug by docking. prognostic model was subsequently constructed via univariate Cox regression analysis, LASSO analysis multivariate Finally, that stably bind screened through dynamics simulation. we validated utility in treating vitro experiments. After 90 related crossed differential genes, 13 cross obtained. might act on following pathways: p53 signaling pathway, cell cycle, cellular sense, mismatch repair, apoptosis-multiple specifications, base example repair DNA replication. Molecular docking revealed combination BAX, FASN, CDK1, PCNA, CLIC1, VWF, RAN, FOXM1, TGM3, CANT1, NSMCE2 proteins relatively stable. A 4-gene constructed. area under curve (AUC) values 1-year, 3-year 5-year survival rates from ROC 0.809, 0.673 0.641, respectively. CDK1 PCNA stable among proteins. CCK8 wound healing assays inhibited proliferation migration cells at increasing concentrations. Western blot experiments achieved therapeutic effects promoting apoptosis cells. Based pharmacology, bioinformatics, simulation, experimental verification, found effect

Language: Английский

Citations

0
Polysaccharides from Anemarrhena asphodeloides Bge, the purification, characterization, biological activities and application of a traditional herbal medicine: A review DOI
Shiyong Gao, Tingting Xu,

Weiya Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143497 - 143497

Published: April 1, 2025

Language: Английский

Citations

0
Xiasangju alleviates hepatic insulin resistance in db/db mice via AMPK pathway: Mechanisms and active components study DOI
Yongcheng An, Hongbin Zhao, Changhao He

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114675 - 114675

Published: April 25, 2025

Language: Английский

Citations

0