Lactobacillus murinus ZNL-13 Modulates Intestinal Barrier Damage and Gut Microbiota in Cyclophosphamide-Induced Immunosuppressed Mice DOI Creative Commons
Yihan Dong, Luyao Zhang, Di Qiu

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1416 - 1416

Published: April 19, 2025

Cyclophosphamide (CTX) is a widely used anticancer drug in clinical practice; however, its administration can lead to gastrointestinal damage and immune suppression. Lactobacillus murinus (L. murinus) has been shown regulate cell activity protect the system, showing potential application as functional food. The objective of this study was investigate effects L. ZNL-13 on CTX-induced intestinal mucosal injury gut microbiota mice. results demonstrated that significantly alleviated weight loss pathological damage. Moreover, mice, enhanced release factors, suppressed apoptosis, protected barrier. Additionally, it activated TLR4/NF-κB pathway, thereby promoting activity. Furthermore, contributed restoration microbial homeostasis by increasing relative abundance short-chain fatty acid-producing bacteria. Taken together, investigation highlights protecting barrier enhancing function while laying groundwork for development novel probiotic

Language: Английский

Lactobacillus murinus ZNL-13 Modulates Intestinal Barrier Damage and Gut Microbiota in Cyclophosphamide-Induced Immunosuppressed Mice DOI Creative Commons
Yihan Dong, Luyao Zhang, Di Qiu

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1416 - 1416

Published: April 19, 2025

Cyclophosphamide (CTX) is a widely used anticancer drug in clinical practice; however, its administration can lead to gastrointestinal damage and immune suppression. Lactobacillus murinus (L. murinus) has been shown regulate cell activity protect the system, showing potential application as functional food. The objective of this study was investigate effects L. ZNL-13 on CTX-induced intestinal mucosal injury gut microbiota mice. results demonstrated that significantly alleviated weight loss pathological damage. Moreover, mice, enhanced release factors, suppressed apoptosis, protected barrier. Additionally, it activated TLR4/NF-κB pathway, thereby promoting activity. Furthermore, contributed restoration microbial homeostasis by increasing relative abundance short-chain fatty acid-producing bacteria. Taken together, investigation highlights protecting barrier enhancing function while laying groundwork for development novel probiotic

Language: Английский

Citations

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