Role of Fruit-Derived Antioxidants in Fighting Cancer: A Narrative Review

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

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Synthesis, Computational, and Photophysical Probing Interactions of Novel Isatin‐Incorporated Thiazolyl‐Coumarins as Potent Antitubercular Agents

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(10)

Published: March 1, 2025

Abstract In this work, we reported the synthesis of a novel series isatin‐incorporated thiazolyl‐coumarin derivatives 4(a–h) by one‐pot three‐component reaction substituted isatin, thiosemicarbazide, and 3‐(2‐bromoacetyl) coumarin. The structures coumarin‐thiazole scaffolds were precisely established their IR, NMR, HRMS spectral data. UV–Vis absorption study target molecules was investigated in six different solvents. Geometrical optimization, molecular electrostatic potential regions, quantum chemical parameters assessed using density functional theory (DFT) to explore electronic properties derivatives. synthesized compounds screened for vitro antimycobacterial activity against Mycobacterium tuberculosis ; all exhibited excellent antitubercular efficacy with MIC ≤ 3.25 µg/mL; among them, 4c 4f most potent 1.56 µg/mL. Furthermore, silico docking analyses enoyl‐ACP reductase (InhA) enzyme conducted; ligands demonstrated favorable binding interactions within active site InhA enzyme.

Language: Английский

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Unrevealing the total phenols, total flavonoids, antioxidant, anti-inflammatory, and cytotoxic effects of Garden Cress seed ethanolic extracts

Review of Clinical Pharmacology and Pharmacokinetics - International Edition, Journal Year: 2024, Volume and Issue: 38(2), P. 187 - 196

Published: July 4, 2024

For many years, natural bioactives have been used to treat, cure, and prevent diseases. Crude extracts from fruit seeds demonstrated possess a range of advantageous biological properties, including anti-inflammatory, antioxidant, anti-tumorous effects. In this study, the Garden Cress (Lepidium sativum, Cr) were extracted using ethanol as solvent two extraction techniques. These methods are microwave-facilitated successive microwave-ultrasound-assisted extraction, resulting in Cr-1 Cr-2, respectively. ethanolic investigated for several biochemical characteristics, flavonoid content, phenolic cytotoxic, cytoprotective The first second characteristics computed colorimetric AlCl3 Folin-Ciocalteu methods, antioxidant char¬acteristic was against reactive species, named hydroxyl DPPH. Also, total reducing power calculated regard. anti-inflammatory-reducing evaluated employing three inflammation-progressing enzymes. last assessed MTT-based methodology malignant one healthy cellular population, outcomes that extract microwave-facilitation (Cr-1) has highest contents, well best activity. Furthermore, when compared other one, showed greater inhibitory effect on enzymes selectivity COX2. At applied concentrations, neither extract, however, had any antiprolifer¬ative or lines. Moreover, no additional influence ability 5-fluorouracil (5-FU) stop proliferation cells. However, individually with 5-FU, cytotoxic capability drug populations substantially lowered. Given these findings, authors concluded together 5-FU may serve measure normal protection.

Language: Английский

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3-mercaptocoumarins as potential bioactive candidates: From novel synthesis to comparative analysis

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1320, P. 139657 - 139657

Published: Aug. 14, 2024

Language: Английский

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Sweet Bell Pepper: A Focus on Its Nutritional Qualities and Illness-Alleviated Properties

Indian Journal of Clinical Biochemistry, Journal Year: 2023, Volume and Issue: 39(4), P. 459 - 469

Published: Dec. 9, 2023

Language: Английский

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