Evaluating the Health Implications of Kombucha Fermented with Gardenia jasminoides Teas: A Comprehensive Analysis of Antioxidant, Antimicrobial, and Cytotoxic Properties DOI Creative Commons
Gayathree Thenuwara,

Xu Cui,

Zhen Yao

et al.

BioChem, Journal Year: 2024, Volume and Issue: 4(4), P. 350 - 370

Published: Dec. 15, 2024

Background/Objectives: Plant-derived compounds are increasingly valued in drug discovery for their therapeutic potential. This study aims to examine the antimicrobial, antioxidant, and anticancer properties of kombucha beverages fermented with Gardenia jasminoides (GJ) various types Camellia sinensis teas: matcha green tea (MGT), organic (OGT), decaffeinated (DGT). Methods: Two experimental designs were employed: (1) using black as a base substrate, infusing four teas post-fermentation over 0–14 days, (2) directly fermenting tea–herb combinations 0–21 days. Antioxidant activity was assessed via DPPH assay. Microbial dynamics analyzed through total mesophilic bacteria Lactobacillus counts. Antimicrobial potential evaluated against E. coli, S. aureus, enteritidis 24 h. Cytotoxicity assays conducted on Caco-2 U251 cell lines assess effects, pH-adjusted controls used differentiate bioactivity from acidity. Results: In first experiment, GJ displayed highest antioxidant (IC50: 14.04 µg/mL), followed by MGT 32.85 µg/mL) OGT 98.21 µg/mL). second setup, unfermented initially showed high 12.94 improving during fermentation reach an IC50 18.26 µg/mL day 21. analysis indicated moderate increases after 14 while MGT, OGT, DGT exhibited higher increments. consistently demonstrated antimicrobial enteritidis, significant inhibitory effects observed that reduced viability 20% at 800 cells maintained 50% same concentration. Conclusions: highlights kombucha, enhancing bioactive metabolite production. Optimizing conditions, identifying specific compounds, expanding cytotoxicity testing, exploring broader applications could maximize its health benefits establish it natural agent.

Language: Английский

Trends, key contributors, and emerging issues in honey and breast cancer: A bibliometric analysis from 2014 to 2024 DOI Creative Commons
Andi Nilawati Usman, Fendi Fendi, Zafitri Nulandari

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 17 - 17

Published: Jan. 3, 2025

Background Honey, a natural product with diverse bioactive compounds, has been increasingly explored for its potential anticancer properties. This study aims to comprehensively analyze the scientific literature on relationship between honey and breast cancer. Methods A bibliometric analysis was conducted using ScienceDirect database identify publications from 2014 2024. Data publication trends, author collaboration, keyword were extracted gain insight into research landscape. Keyword identified nine distinct clusters, indicating directions regarding role of in cancer treatment. Results Key journals such as Journal Ethnopharmacology Food Chemistry have at forefront disseminating findings this domain, demonstrating strong interdisciplinary approach that bridges traditional medicine modern inquiry. The increasing interest properties honey, evidenced by growing number studies, underlines promising agent prevention Recent advances synthesis theranostic paradigms cerium oxide nanoparticles (CeONPs) highlighted, well selenium nanoconstructs. toxicity quality control Perillae Fructus also highlighted. Conclusions provides comprehensive overview current state knowledge uncovers emerging issues require further investigation.

Language: Английский

Citations

0
Trends, key contributors, and emerging issues in honey and breast cancer: A bibliometric analysis from 2014 to 2024 DOI Creative Commons
Andi Nilawati Usman, Fendi Fendi, Zafitri Nulandari

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 17 - 17

Published: Jan. 20, 2025

Background Honey, a natural product with diverse bioactive compounds, has been increasingly explored for its potential anticancer properties. This study aims to comprehensively analyze the scientific literature on relationship between honey and breast cancer. Methods A bibliometric analysis was conducted using ScienceDirect database identify publications from 2014 2024. Data publication trends, author collaboration, keyword were extracted gain insight into research landscape. Keyword identified nine distinct clusters, indicating directions regarding role of in cancer treatment. Results Key journals such as Journal Ethnopharmacology Food Chemistry have at forefront disseminating findings this domain, demonstrating strong interdisciplinary approach that bridges traditional medicine modern inquiry. The increasing interest properties honey, evidenced by growing number studies, underlines promising agent prevention Recent advances synthesis theranostic paradigms cerium oxide nanoparticles (CeONPs) highlighted, well selenium nanoconstructs. toxicity quality control Perillae Fructus also highlighted. Conclusions provides comprehensive overview current state knowledge uncovers emerging issues require further investigation.

Language: Английский

Citations

0
Comparative analysis of microbial diversity in various kombucha starter cultures in Malaysia using the random amplified polymorphic DNA (RAPD) approach DOI Open Access

Nur Syafiqah Syahmimie Augustine,

Eric Tzyy Jiann Chong, Carissa Wong

et al.

Asia-Pacific Journal of Molecular Biology and Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Jan. 31, 2025

Kombucha is sweetened black tea fermented with symbiotic culture of bacteria and yeasts (SCOBY) has been widely consumed for its purported health benefits. The microbial consortium in kombucha dominated by such as Brettanomyces sp. Zygosaccharomyces sp., well acetic acid (AAB), Komagataeibacter Acetobacter However, the source SCOBY substrates used may affect diversity biochemical, flavour kombucha. Identifying population important use undefined starter cultures lead to variable metabolite production increase risk food pathogen contamination which can pose harm human health. This study aims isolate microbes from Malaysia future development a new specific species safe consumption Briefly, total 100 colonies were isolated nine selective plates. Differences colony morphology observed based on their colours, surface texture, elevation, margin. Their phenotypic genetic screened using microscopic examination, coupled catalase test random amplified polymorphic DNA (RAPD), respectively. Based data, 51% isolates showed under while rest bacteria. Additionally, 55.79% distinct banding profile patterns RAPD assessments. In conclusion, data this shows that there diverse different Malaysia, mainly predominated Gram-negative AAB Gram-positive yeasts. Identification at level be conducted future. By understanding microbiota kombucha, it contributes functional drink.

Language: Английский

Citations

0
Trends, key contributors, and emerging issues in honey and breast cancer: A bibliometric analysis from 2014 to 2024 DOI Creative Commons
Andi Nilawati Usman, Fendi Fendi, Zafitri Nulandari

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 17 - 17

Published: March 24, 2025

Background Honey, a natural product with diverse bioactive compounds, has been increasingly explored for its potential anticancer properties. This study aims to comprehensively analyze the scientific literature on relationship between honey and breast cancer. Methods A bibliometric analysis was conducted using ScienceDirect database identify publications from 2014 2024. Data publication trends, author collaboration, keyword were extracted gain insight into research landscape. Keyword identified nine distinct clusters, indicating directions regarding role of in cancer treatment. Results In Key journals such as Journal Ethnopharmacology Food Chemistry have at forefront disseminating findings this domain, demonstrating strongly interdisciplinary approach that bridges traditional medicine modern inquiry. The increasing interest properties honey, evidenced by growing number studies, underlines promising agent prevention Conclusions provides comprehensive overview current knowledge landscape highlights emerging issues require further exploration.

Language: Английский

Citations

0
A review of the research on microbial diversity and its effects on components and functions of Kombucha DOI
Shuang Yang

Highlights in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 139, P. 93 - 99

Published: April 28, 2025

Kombucha is a healthy beverage rich in functional active ingredients and has multiple health benefits. At present, become global research hotspot very broad market prospect. The diversity of microbial communities significantly affects the benefits Kombucha. development modern biological methods, especially independent culture analysis techniques, provided comprehensive understanding community structure This article reviews progress on Kombucha, including population composition interactions microorganisms during fermentation, methods influencing factors diversity, as well artificial regulation assembly communities. will provide theoretical reference for improving quality safety innovating products through

Language: Английский

Citations

0
Evaluating the Health Implications of Kombucha Fermented with Gardenia jasminoides Teas: A Comprehensive Analysis of Antioxidant, Antimicrobial, and Cytotoxic Properties DOI Creative Commons
Gayathree Thenuwara,

Xu Cui,

Zhen Yao

et al.

BioChem, Journal Year: 2024, Volume and Issue: 4(4), P. 350 - 370

Published: Dec. 15, 2024

Background/Objectives: Plant-derived compounds are increasingly valued in drug discovery for their therapeutic potential. This study aims to examine the antimicrobial, antioxidant, and anticancer properties of kombucha beverages fermented with Gardenia jasminoides (GJ) various types Camellia sinensis teas: matcha green tea (MGT), organic (OGT), decaffeinated (DGT). Methods: Two experimental designs were employed: (1) using black as a base substrate, infusing four teas post-fermentation over 0–14 days, (2) directly fermenting tea–herb combinations 0–21 days. Antioxidant activity was assessed via DPPH assay. Microbial dynamics analyzed through total mesophilic bacteria Lactobacillus counts. Antimicrobial potential evaluated against E. coli, S. aureus, enteritidis 24 h. Cytotoxicity assays conducted on Caco-2 U251 cell lines assess effects, pH-adjusted controls used differentiate bioactivity from acidity. Results: In first experiment, GJ displayed highest antioxidant (IC50: 14.04 µg/mL), followed by MGT 32.85 µg/mL) OGT 98.21 µg/mL). second setup, unfermented initially showed high 12.94 improving during fermentation reach an IC50 18.26 µg/mL day 21. analysis indicated moderate increases after 14 while MGT, OGT, DGT exhibited higher increments. consistently demonstrated antimicrobial enteritidis, significant inhibitory effects observed that reduced viability 20% at 800 cells maintained 50% same concentration. Conclusions: highlights kombucha, enhancing bioactive metabolite production. Optimizing conditions, identifying specific compounds, expanding cytotoxicity testing, exploring broader applications could maximize its health benefits establish it natural agent.

Language: Английский

Citations

1